摘要:

Forty-seven patients with poor-prognosis myeloid leukemias received induction therapy with high-dose cytosine arabinoside (HDara-C), 1.5–3.0g/m2for 8–10 doses, and mitoxantrone (DHAD), 12–15 mglm2for 3 doses. Complete remissions were achieved in 21 [45%, 95% confidence interval (CI) 30.2–59.9%]of the patients, including 11 of 14 with acute myelogenous leukemia (AML) in first relapse (79%, 95% CI 49.2–95.3%), 4 of 8 with refractory anemia with excess blasts in transformation (RAEBiT) (50%, 95% CI 15.4–84.6%), and 4 of 6 (67%, 95% CI 22.3–95.7%) previously untreated elderly AML patients. Patients with secondary AML and advanced chronic myelogenous leukemia had a very low response rate. The incidence of reversible toxicity was low and only 3 treatment-related deaths occurred. After reinduction, 8 of 9 AML patients≤60 years of age were ultimately able to undergo intensive therapy and either autologous 4-hydroperoxycyclo-phosphamide-purged bone marrow (7 patients) or peripheral blood stem cell (1 patient) transplantation with satisfactory hematological recovery. We conclude that HDara-C and DHAD is an effective antileukemic regimen in selected AML and RAEBiT patients, and that its use may allow subsequent successful autologous BMT in appropriate patients.

ISSN:0735-7907    

DOI:10.3109/07357909309011668

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

摘要:

We studied the production of chemiluminescence (CL) by peripheral blood neutrophils from 24 normal subjects, 13 lung cancer patients with clinical stages (CS) III and IV, and 27 breast cancer patients with CS II, III, and IV. Evaluations were made before chemo- and radiotherapy treatments. CL was expressed as: baseline of the record background activity; area under the curve (AUC) of opsonized zymosan response; maximum peak (MP) response; time to MP (TMP); and total time (TT). Simultaneously, circulating immune complexes (CIC) in sera were evaluated by polyethylene glycol precipitation technique. The results demonstrated that lung cancer patients with CS III had an increase of TMP and TT values, while breast cancer patients with CS IV showed the lowest values of AUC and MP compared with the control group. The CIC levels were increased in all the cancer patients. There was no correlation between the baseline CL activity and the levels of immune complexes.

ISSN:0735-7907    

DOI:10.3109/07357909309011669

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

摘要:

Guanosine is shown to potentiate markedly the antiproliferative effect of cytosine-β-D-arabinoside (ara-C) on B16 F10 mouse and SKMEL-28 human melanoma cell lines. Several metabolic consequences of the synergistic interaction between ara-C and guanosine on cell growth were determined in BI6 F10 mouse melanoma cells. Treatment of the cells with guanosine for 24hr resulted in an increase in the percentage of cells in the S phase of the cell cycle, a threefold increase in intracellular GTP concentration, and an increase in the incorporation of ara-C into acid-insoluble material and phosphorylated metabolites. These findings suggest that guanosine potentiates the growth-inhibitory effect of ara-C in B16 F10 melanoma cells by increasing the intracellular concentration of its active metabolites.

ISSN:0735-7907    

DOI:10.3109/07357909309011670

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

摘要:

Changes in the deoxyribonucleotide pools following a single oral administration of 13 mglkg of 5-fluorouracil (5-FU) or of 64.8 mglkg of UFT (a mixed compound of tegafur and uracil) were investigated. We compared their pharmacodynamics and effects on nucleotide metabolism in L1210 ascites tumor on day 3 after intraperitoneal tumor inoculation. The intracellular dTTP pool decreased to half the control level 1–6 hr after the administration of 5-FU. The dTTP pools rapidly recovered after 6 hr. In contrast, UFT kept the intracellular dTTP level to 1/3 to 1/2 of the control level for 24 hr. Either drug elevated the intracellular dATP pools, but decreased dCTP pools. UFT influenced the intracellular dATP and dCTP levels longer than 5-FU. Orally administered UFT seemed to exert a longer and more potent inhibitory effect on thymidylate synthetase than equimolar 5-FU. In view of these results, we suggest that UFT could be a more potent chemotherapeutic drug than 5-FU in oral administration.

ISSN:0735-7907    

DOI:10.3109/07357909309011671

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309011672

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309011673

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309011674

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

摘要:

The patient requiring ostomy surgery has needs above and beyond the typical perioperative needs of an individual experiencing major abdominal surgery. These needs may be categorized as technical ostomy management, information, and emotional support. The health care team managing ostomy patients must be prepared to address the patients'' needs in these three categories. This can be accomplished when the multidisciplinary team establishes a comprehensive plan of care that consists of five elements: information, technical expertise, psychosocial support, referrals, and surveillance. Each element plays a critical role in the patients' adaptation to ostomy surgery. Pertinent aspects of each element are described. By incorporating these elements into the plan of care, the health care team engenders patient adaptation to ostomy surgery.

ISSN:0735-7907    

DOI:10.3109/07357909309011675

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309011676

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357909309011677

出版商:Taylor&Francis    

年代:1993

数据来源: Taylor