摘要:

AbstractFragments of the KHT sarcoma were transplanted into the right rear legs of C3H/He mice. At 10 days, groups of 16 to 20 mice had the consequent developing tumor treated by local irradiation (40 Gy in 2 fractions), levamisole (5 mg/kg every 2nd day), local hyperthermia, or a combination of these treatments. Local tumor control, the incidence and sites of metastatic spread, and survival times were measured. Radiation alone controlled 25% of the local tumors, but 75% of the treated mice developed metastases. Radiation combined with levamisole increased local control to 31 % with a corresponding decrease in the incidence of metastases. Hyperthermia alone prolonged the survival time compared to nontreated mice. This increase in survival time was lost when levamisole was combined with hyperthermia. Combined hyperthermia and irradiation controlled 89% of tumors. This corresponded to a thermal enhancement factor of 3.5. When levamisole was added to hyperthermia and irradiation, local tumor control was decreased and the incidence of metastases was increased compared to the combination treatment of irradiation and hyperthermia. The nonspecific immune stimulant levamisole was antagonistic to the action of hyperthermia on the KHT tumor. An hypothesis to explain this antagonism is proposed.

ISSN:0735-7907    

DOI:10.3109/07357908609017507

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

摘要:

AbstractTo characterize the neurological complications of cancer patients admitted to a community hospital, the charts of all cancer patients evaluated by a neurologist during a single year were reviewed. Nine percent (N = 93) of cancer patients received neurological consultation compared to 3.6% of other patients. The neurologic problem preceded the diagnosis of cancer in 11% of patients. Complications were most common with known metastases. Neurologists frequently discovered signs not noted by the referring physician: 52 patients were paretic, with weakness reported in only 31; cranial nerve complaints were described in 3, but found in 20; sensory abnormalities were noted in 8, but found in 26. A change in mental status was confirmed in 33% and ataxia in 10%. After consultation, distant metastasis was diagnosed in 40% of patients, direct extension in 8%, metabolic encephalopathy in 14% and remote effects of cancer and side effects of cancer therapy in 4% each. Other patients had unrelated diagnoses. In most cases, the neurologic consultation led to a change in treatment, with radiotherapy directed to a symptomatic tumor mass the most common beneficial outcome.

ISSN:0735-7907    

DOI:10.3109/07357908609017508

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

摘要:

AbstractPolymorphonuclear leukocytes (PMN) from healthy, normal control cats and FeLV-infected cats were analyzed for differences in phagocytic capabilities. One week after experimental infection, PMNs from FeLV-infected cats exhibited a marked decrease in phagocytic function as determined by the luminol-dependent chemiluminescent response. Depressed PMN function was observed in these cats during the viremic stage of infection and subsequently remained depressed after the cessation of viremia. The data presented here suggest that while nonviremic cats are reported as clinically normal, they may in fact be exhibiting a suppressed PMN function.

ISSN:0735-7907    

DOI:10.3109/07357908609017509

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

摘要:

AbstractAn elderly woman with Hodgkin 's disease and hepatic involvement but without cholestasis presented with markedly depressed levels of serum esterified cholesterol and high density lipoproteins (HDL). Within five days of her first cycle of chemotherapy her serum HDL-cholesterol rose from 8–10 mg/dl to 88 mg/dl, and levels of the major HDL-apoprotein, apoA-I, rose from 60 to 138 mg/dl. The proportion of unesterified serum cholesterol fell from 60–80% to 27–30%. These observations suggest a relatively specific effect of the hepatic lymphoma on synthesis or release of lecithin:cholesterol acyltransferase.

ISSN:0735-7907    

DOI:10.3109/07357908609017510

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908609017511

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908609017512

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908609017513

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908609017514

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

ISSN:0735-7907    

DOI:10.3109/07357908609017515

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor

摘要:

AbstractCancer Today: Origins, Prevention and Treatment By Leslie Roberts, 132 pp, illustrated Washington, D. C. Institute of Medicine/National Academy Press, 1984 $9.95 paperback

ISSN:0735-7907    

DOI:10.3109/07357908609017516

出版商:Taylor&Francis    

年代:1986

数据来源: Taylor