摘要:

SummaryThe evaluation of treatment and outcome in adult leukaemia requires unselected data. Such data is available from one Health Region in the United Kindgom with an adult population of 3.1 million. In the period July 1982 to December 1989, 676 cases of acute myeloid leukaemia (AML), 136 of acute lymphoblastic leukaemia (ALL) and 141 of chronic granulocytic leukaemia (CGL) were registered. The median survival for AML was 21 weeks and 26% of these patients died within 4 weeks of diagnosis. For ALL, the corresponding figures were 81 weeks and 21%. In CGL, the median survival was significantly different for males and females: 113 weeks and 173 weeks respectively. The 5‐year survival in AML was 9%, in ALL, 31% and in CGL, 29% (20% for males, 45% for females). Age at presentation was the single most powerful prognostic factor and probably accounts for survival differences between patients referred to tertiary centres and those treated in district general hospitals. (DGH). Survival may be improving overall as supportive care improve

ISSN:0141-9854    

DOI:10.1111/j.1365-2257.1992.tb01066.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryThe techniques of Western blotting and the monoclonal antibody specific immobilization of platelet antigen (MAIPA) assay were used to detect antibodies to platelet glycoproteins in 43 samples of serum from 23 anti‐HIV positive haemophiliacs (8 with severe thrombocytopenia, 6 with moderate thrombocytopenia, and 9 with a normal platelet count), six anti‐HIV negative haemophiliacs and ten controls. Antibodies were present in the majority of anti‐HIV positive patients' sera even before the onset of thrombocytopenia. Thrombocytopenia was associated with an increase in the incidence of antibodies to GPIIIa and GPIb, whereas the antigen most frequently recognized in patients without thrombocytopenia was GPIIb. Anti‐GPIIb and/or GPIIIa reactivity was also seen in three out of the six anti‐HIV negative patients. There was no correlation between the absolute platelet count and the detection of antibodies in either assay. Effective therapy for thrombocytopenia with zidovudine, interferon or splenectomy did not influence the presence of antibody. Eight of nine patients with AIDS were negative in the MAIPA assay, consistent with their depressed immune status. It is concluded that the production of antibodies to platelet membrane glycoprotein in anti‐HIV positive haemophiliacs is influenced by factors other than HIV. The presence of such antibodies is independent of the platelet count and is therefore unlikely to play a causative role in HIV‐related thr

ISSN:0141-9854    

DOI:10.1111/j.1365-2257.1992.tb01067.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryPlatelet antigens of platelet samples from 36 donors, frozen for different intervals, were evaluated by the platelet suspension immunofluorescence test (PSIFT). A, B, PLA1(HPA‐la) and various HLA antigens were tested by their corresponding antisera. The antigen could be detected in almost all the samples after one month of freezing. After 3 and 6 months, the platelet antigens could only be detected in 29.2% and 3.7% of the samples, respectively. There was no difference in decay of antigen expression among A, B, PLA1and HLA antigens. When compared with the freshly prepared platelets, frozen platelets presented stronger antigen expression after 2 to 4 weeks of storage. This may suggest that the frozen platelets could be used for platelet crossmatching procedures without loss of their antigenicity within one mont

ISSN:0141-9854    

DOI:10.1111/j.1365-2257.1992.tb01068.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryWe describe a case of proven invasive pulmonary aspergillosis in a neutropenic patient in whom disease progression occurred during treatment with conventional amphotericin B despite neutrophil recovery. Treatment with liposomal encapsulated amphotericin B resulted in clinical and radiological improvement and the clearance of aspergillus spores from the sputum.

ISSN:0141-9854    

DOI:10.1111/j.1365-2257.1992.tb01069.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryThe last few years have seen dramatic changes in laboratory haematology. Technological developments with increasing levels of automation have resulted in a plethora of new instruments. The choice of which to buy, often confused by conflicting advice and persuasive salesmanship, must be balanced by the need for cost containment. This calls for an understanding of the principles of selection to ensure that the system that is chosen will provide reliable results in the most efficient manner at the lowest possible cost. Most of the instruments which are currently available perform their intended tasks reasonably well albeit with some inter‐instrument differences, usually due to different operating procedures and different methods of calibration. The task is to find a system that performs the required tests correctly and reliably, fits into the work requirements of the laboratory and is accepted by the staff who will operate it, whilst its cost, both capital and recurrent, should be within the department's financial constraints. The selection of laboratory equipment is thus a complex and time consuming tas

ISSN:0141-9854    

DOI:10.1111/j.1365-2257.1992.tb01070.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

摘要:

SummaryHuman blood monocytes were cultured within the wells of chamber slides in growth medium to which 0, 1, 2 or 3 mg ethanol per ml was added at the start of the culture. After incubation for 1 h, 1 day and 7 days, their ability to phagocytoze IgG‐sensitized red cells and to phagocytoze and kill non‐opsonizedCandida albicanswas assessed. In all alcohol‐containing wells, the concentration of alcohol in the growth medium fell progressively, reaching negligible values after 3 days. When compared with control cells, monocytes incubated with 1, 2 or 3 mg ethanol/ml for 1 h showed impaired phagocytosis of IgG‐sensitized RBC and non‐opsonizedC. albicansand those incubated with 1 or 2 mg ethanol/ml for 1 h showed impaired killing of Candida. After incubation for 7 days, the monocyte‐derived macrophages in wells initially containing 1, 2 or 3 mg ethanol/ml showed increased phagocytic activity towardsC. albicansbut not towards sensitized RBC. In addition, in 4 of 5 experiments, the percentage of phagocytozed organisms killed was increased in wells initially containing 1 mg ethanol/ml. The results support the view that the susceptibility of chronic alcoholics to certain infections may be partly dependent on an ethanol‐induced depression of the phagocytic and killing functions of macrophages. They also suggest that a few days after a brief period of exposure to ethanol there may be stimulation of certain but not all effector functions o

ISSN:0141-9854    

DOI:10.1111/j.1365-2257.1992.tb01071.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0141-9854    

DOI:10.1111/j.1365-2257.1992.tb01072.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0141-9854    

DOI:10.1111/j.1365-2257.1992.tb01073.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0141-9854    

DOI:10.1111/j.1365-2257.1992.tb01074.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY

ISSN:0141-9854    

DOI:10.1111/j.1365-2257.1992.tb01075.x

出版商:Blackwell Publishing Ltd    

年代:1992

数据来源: WILEY