摘要:

AbstractTwo different syntheses of (5), one labeled with carbon‐14 in the quinonoid ring and the other in the phenyl ring are described. Treatment of p‐[U‐14C]benzoquinone with 2‐amino‐5‐methoxy benzenethiol yielded (7), which was methoxylated to provide a mixture of isomers (4a) and (8). Separation of isomers followed by bromination of (4a) gave (5a). Thiocyanation of p‐[U‐14C]anisidine provided (10), which was hydrolysed to give labeled aminothiol (3b); the latter was condensed with 2‐bromo‐6‐methoxy‐p‐be

ISSN:0362-4803    

DOI:10.1002/jlcr.2580240112

出版商:John Wiley&Sons, Ltd.    

年代:1987

数据来源: WILEY

摘要:

AbstractA method was developed to synthesize14C‐labelled n‐alkanes for use in cigarette smoke studies. Specifically, n‐[18‐14C]‐octatriacontane was synthesized from 1 mCi [1‐14C]stearic acid in a radiochemical yield of 20%. The key features of this synthesis were two consecutive alkylations of tosylmethyl isocyanide followed by acid hydrolysis to [18‐14C]‐19‐octatriacontanone and modified Wolff‐Kishner reduction to the n‐alkane. After purification on silica gel 25 mg of [18‐14C]octatriacontane was obtained with a total radioactivity of 200 μCi, a specific activity of 4.3 mCi/mmol, and a radiochemical purity in excess of 98% by thin layer radiochromatography. The method has also been applied to the synthesis of unlabeled n‐pentatriacontane and is considered to be generally applicable to the synthesis of radiolabeled alkanes fro

ISSN:0362-4803    

DOI:10.1002/jlcr.2580240113

出版商:John Wiley&Sons, Ltd.    

年代:1987

数据来源: WILEY

ISSN:0362-4803    

DOI:10.1002/jlcr.2580240101

出版商:John Wiley&Sons, Ltd.    

年代:1987

数据来源: WILEY