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| 11. |
Tritium labelled (±)‐10‐[2‐(1‐methyl‐2‐piperidinyl)ethyl]‐2‐(methyl‐mercapto)‐[3‐3H(n)]phenothiazine (thioridazine) |
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Journal of Labelled Compounds and Radiopharmaceuticals,
Volume 23,
Issue 1,
1986,
Page 95-101
Steven D. Wyrick,
Richard B. Mailman,
Diane M. Niedzwiecki,
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摘要:
AbstractThe antipsychotic drug, thioridazine, differs from more classical antipsychotic drugs with respect to both some atypical psychopharmacological characteristics and to the critical involvement of active metabolites in its pharmacology. Tritium labelled thioridazine has been prepared in our laboratory by palladium catalyzed reduction of an aryl brominated precursor using carrier free tritium gas in THF. The product is labelled in the 3‐position of the phenothiazine ring system and a specifie activity of 12 Ci/mmole was obtaine
ISSN:0362-4803
DOI:10.1002/jlcr.2580230112
出版商:John Wiley&Sons, Ltd.
年代:1986
数据来源: WILEY
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| 12. |
Syntheses of 2‐(diacetoxymethyl‐14C)‐5‐nitrofuran and carbon‐14 labeled nitrofurazone |
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Journal of Labelled Compounds and Radiopharmaceuticals,
Volume 23,
Issue 1,
1986,
Page 103-108
Richard I Duclos,
Betty‐Ann Hoener,
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摘要:
AbstractA new method for the microscale syntheses of carbon‐14 labeled 5‐nitrofuran derivatives of high specific activities was developed. Ethyl 2‐furancarboxylate‐carboxy‐14C (3) was prepared in an improved yield from Ba14CO3. 2‐Furancarboxaldehyde‐formyl‐14C (5) was prepared by reduction of the ester 3 followed by γ‐MnO2oxidation of 2‐(hydroxymethyl‐14C)furan (4). 2‐(Diacetoxymethyl‐14C)‐5‐nitrofuran (7), an immediate precursor of many radiolabeled 5‐nitrofuran drugs, was prepared in a new two‐reaction one‐flask procedure from 2‐furancarboxaldehyde‐formyl‐14C (5) in 7.3% overall radiochemical yield from Ba14CO3. Carbon‐14 labele
ISSN:0362-4803
DOI:10.1002/jlcr.2580230113
出版商:John Wiley&Sons, Ltd.
年代:1986
数据来源: WILEY
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| 13. |
Preparation of |2,4‐2H|‐ and |2,4‐3H|‐tomatidine |
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Journal of Labelled Compounds and Radiopharmaceuticals,
Volume 23,
Issue 1,
1986,
Page 109-112
D. Doller,
E. G. Gros,
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摘要:
AbstractThe preparation of |2,4‐2H|‐ and |2,4‐3H|‐tomatidine was accomplished by oxydation of the unlabelled compound to tomatidone, exchange of the labile hydrogens by reaction with H20and3H2O on basic alumina and direct reduction of the labelled tomatidone to tomatidine. The efficiency of the procedure was checked by physical (1H and13C NMR, MS)
ISSN:0362-4803
DOI:10.1002/jlcr.2580230114
出版商:John Wiley&Sons, Ltd.
年代:1986
数据来源: WILEY
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| 14. |
NCRP Report No 58 Second Edition A Handbook of Radioactivity Measurement Procedures Pub: NCRP Publications, 7910 Woodmont Avenue, Bethesda. Maryland, USA September 12, 1984 Price: 25.00 US dollars |
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Journal of Labelled Compounds and Radiopharmaceuticals,
Volume 23,
Issue 1,
1986,
Page 113-113
A G Tuck,
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PDF (53KB)
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ISSN:0362-4803
DOI:10.1002/jlcr.2580230115
出版商:John Wiley&Sons, Ltd.
年代:1986
数据来源: WILEY
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| 15. |
Masthead |
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Journal of Labelled Compounds and Radiopharmaceuticals,
Volume 23,
Issue 1,
1986,
Page -
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PDF (59KB)
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ISSN:0362-4803
DOI:10.1002/jlcr.2580230101
出版商:John Wiley&Sons, Ltd.
年代:1986
数据来源: WILEY
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