摘要:

AbstractStepwise deuteration of the acidic methylene group of lidocaine (1) on a large scale using a moderate excess of2H2O in triethylamine/pyridine at 200° is described (Table 1). The efficient and economical preparation of bideuterated lidocaine (3) facilitates the use of this compound as an excellent internal standard in lidocaine determination or as a tracer in lidocaine pharmacokinetics

ISSN:0362-4803    

DOI:10.1002/jlcr.2580250112

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY

摘要:

AbstractThe synthesis of phenyl‐U‐carbon‐13 labelled D,L‐norepinephrine from catechol‐U‐13C in three steps is described. In the first step, the Friedel‐Crafts acylation of the labelled part with N‐phthaloylglycylchloride yielded the aromatic ketone adduct. Subsequent hydrolysis and catalytic hydrogenation produced the desired product in a 5

ISSN:0362-4803    

DOI:10.1002/jlcr.2580250113

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY

摘要:

AbstractEfficient syntheses of (±) [2‐2H2]mevalonolactone and (±) [2‐2H2]homomevalonolactone involving condensations of lithiotrimethylsilyl [2‐2H2]acetate with appropriate 3‐oxo‐alcohols are described. Regiospecificity of the label was established by NMR s

ISSN:0362-4803    

DOI:10.1002/jlcr.2580250114

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY

ISSN:0362-4803    

DOI:10.1002/jlcr.2580250101

出版商:John Wiley&Sons, Ltd.    

年代:1988

数据来源: WILEY