摘要:

AbstractMethyl‐14C iodide of high specific activity was converted to carbon‐14 disulfide in quantitative yield by reaction with phosphorus pentasulfide at 300–325°C. Following literature procedures, N,N′ dicyclohexylcarbo‐14C‐diimide was prepared in 54% yield from the carbon

ISSN:0362-4803    

DOI:10.1002/jlcr.2580130111

出版商:John Wiley&Sons, Ltd.    

年代:1977

数据来源: WILEY

摘要:

AbstractA simple procedure is described for the preparation of millicurie quantities of the cancer chemotherapeutic agent, BCNU, labeled in the nitroso group with13N.

ISSN:0362-4803    

DOI:10.1002/jlcr.2580130112

出版商:John Wiley&Sons, Ltd.    

年代:1977

数据来源: WILEY

摘要:

AbstractLithium borotritide reduction of α‐ionylidene‐acetaldehyde (5) followed by manganese dioxide oxidation provided the tritiated aldehyde (9) which retainad over 95% of the label. On treatment with the ylide derived from ethyl 4‐chloro‐3‐methylcrotonate, ethyl α‐retinoate‐11‐3H (14) was obtained which, after purification, was hydrolyzed to α‐retinoic‐11‐3H acid (15). Conversion to the methyl ester (16) followed by lithium aluminum hydride reduction yielded alltrans‐ α‐retinol (17) which was isolated a

ISSN:0362-4803    

DOI:10.1002/jlcr.2580130113

出版商:John Wiley&Sons, Ltd.    

年代:1977

数据来源: WILEY

摘要:

AbstractA short and very convenient method is described for the preparation of cysteine‐35S‐sulfate using unlabeled cysteine ‐S‐sulfate and L‐cysteine‐35S. This method provides an 80% yield and can be used for microquantit

ISSN:0362-4803    

DOI:10.1002/jlcr.2580130114

出版商:John Wiley&Sons, Ltd.    

年代:1977

数据来源: WILEY

摘要:

AbstractChloral‐1,2‐14C hydrate was prepared by direct chlorination of labeled acetaldehyde in an overall 47% radiochemical yield. The reaction was carried out without a catalyst by heating at one temperature in a single stage reaction. No lower chloroacetaldehydes were detec

ISSN:0362-4803    

DOI:10.1002/jlcr.2580130115

出版商:John Wiley&Sons, Ltd.    

年代:1977

数据来源: WILEY

摘要:

AbstractA simple and general method for the synthesis of folate analogs labeled in the glutamate moiety with14C is described. The synthesis makes use of the trimethylsilyl derivative of L‐glutamic acid 8 for the coupling reaction with the activated pteroate analogs. Deprotection under mild conditions circumvented the potential problems associated with deamination at the 4‐position of 2. Methotrexate, folic acid, and N10‐ methyl folic acid were prepared in ˜50% yield by the use of this pro

ISSN:0362-4803    

DOI:10.1002/jlcr.2580130116

出版商:John Wiley&Sons, Ltd.    

年代:1977

数据来源: WILEY