摘要:

Abstract[2‐14C]‐Methylglyoxal bis(guanylhydrazone) dihydrochloride, [14C]‐mitoguazone, 3, has been prepared in three steps from potassium [1‐14C]‐acetate in an overall radiochemical yield of 16%. The key steps in this procedure are the formation of the sodium salt of [acetone‐2‐14C]‐methylsulfinylacetone,5, and Pummerer rearrangement to the [14C] labelled hemithioacetal,6, which is trapped with two equivalents of aminoguanidine to afford the desired [14C

ISSN:0362-4803    

DOI:10.1002/jlcr.2580360112

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY

摘要:

AbstractThe enantiomers of [3‐3H]‐2‐[[4‐[(7‐chloro‐4‐quinolinyl)amino]pentyl]ethylamino]ethanol,[3‐3H]‐hydroxychloroquine, (R)‐8 and (S)‐8, have been prepared in two steps from the known precursors 4,7‐dichloro‐3‐iodoquinoline,4, and the enantiomers of 2‐[(4‐aminopentyl)ethylamino]ethanol, (R)‐2 and (S)‐2, by formation of the enantiomers of 2‐[[4‐[(7‐chloro‐3‐iodo‐4‐quinolinyl)amino]pentyl]ethylamino]ethanol, (R)‐3 and (S)‐3, and subsequent reductive deiodin

ISSN:0362-4803    

DOI:10.1002/jlcr.2580360113

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY

ISSN:0362-4803    

DOI:10.1002/jlcr.2580360101

出版商:John Wiley&Sons, Ltd.    

年代:1995

数据来源: WILEY