摘要:

AbstractThis article describes the radiosynthesis of11C‐labelled S‐adenosylmethionine by an enzymatic process. This methyl donor was prepared by condensation of L‐(methyl‐11C) methionine with ATP. The synthesis and purification could be carried out in 20 minutes with a final yield of 80 %. The specific radioactivity obtained was close to 200 Ci/mmole. 6 mCi of11C‐labelled S‐adenosylmethionine was injected in a rabbit, and its repartition followed by an

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190202

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractTritiation of thyroliberin (L‐(Glu‐L‐His‐L‐Pro‐NH2) starting from the L‐[Δ3‐Pro3]‐TRF, on prolyl and histidyl residues is being dealt with below.By catalytic tritiation of the double bond, followed by iodination of histidyl residue and catalytic deshalogenation in presence of tritium gas, TRF was labelled with a specific radioactivity close to the theoretical value.3H‐[2,5‐His2‐3,4‐Pro3]‐TRF retai

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190203

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractSynthesis of (1‐14C‐indenyl) dimethindene (7‐14C) benzyl chloride prepared from (14C) barium carbonate is condensed with diethyl sodio malonate to give diethyl (7‐14C) benzyl malonate : 4 in a yield of 78 %.4is then alkylated with 2‐dimethylamino 1‐chloroethane to give the diethyl dialkylmalonate :12.12is saponified with sodium hydroxide, decarboxylited by treatment with hot hydrochloric acid and cyclised with polyposphoric acid into 2‐(2‐dimethyl aminoethyl) 3‐(1‐ C) indanone : 8. This indanone is condensed with 2‐(2‐lithioethyl) pyridine, the intermediate is dehydrated into (1‐ C indenyl) Dimethindene which is isolated and purified as its maleate salt. Specific activity is 54 mCi/mMole. Radiochemical purity checked by TLC is better than 99%. The overall yield is 15.8 %

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190204

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractSyntnesis of very high specific activity (4,6‐14C2) 2‐isopropylaminopyrimidine phosphate (I.A.P.P.)(1‐14C) Sodium acetate (specific activity : 57 mCi/mMole)‐ was transformed into ethyl (1‐ C) acetate with a 76 % yield. The latter was lithiated with lithiodiisopropylamide. The intermediate ethyl (1‐14C) lithioacetate was carbonated with14CO2(specific activity : 57 mCi/mMole) to give monoethyl (1,3‐14C2) malonate which was esterified into diethyl (1,3‐14C2) malonate. The latter was condensed with N‐isopropylguanidne to give 4,6‐dihydroxy 2‐iso‐propylamino (4,6‐14C2) pyrimidine. Treatment with POBr3gave 4,6‐dibromo 2‐isopropylamino (4,6‐14C2) pyrimidine the hydrogenation of which under controlled conditions gave 2‐isopropylamino (4,6‐14C2) pyrimidine isolated as the phosphate. Specific activity was 114 mCi/mMole, radiochemical purity (TLC and HPLC) was 99 % ‐ overall yield

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190205

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractTo exploit the tissue affinity of compounds for radiopharmaceutical purposes, attachment of chelating groups is usually necessary to facilitate technetium‐99m binding and transport.The chelating group, iminodiacetic acid, previously used to modify lidocaine for hepatobiliary radiopharmaceuticals, was attached to several antibiotic sulfanilamides known to concentrate in certain transplanted animal tumors.These iminodiacetic acid derivatives were labelled with technetium‐99m by the stannous chloride reduction method.Biodistribution of the99mTc labelled compounds in tumor bearing rats revealed no specific concentration in the tumors and localization mainly in the excretory organs.The results indicate that, as in the case of lidocaine, conversion of the sulfanilamides into iminodiacetic acid derivatives and chelation with technetium leads to an altered biodistribution and loss of biological specific

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190206

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractSeveral catalytic tritium exchange procedures have been investigated in order to accomplish uniform and random incorporation of tritium into the diverse organic solutes present in an oil shale process water. Comparative proton and tritium nuclear magnetic resonance (NMR) spectroscopy revealed that a Raney nickel/THO system resulted in a reproducible procedure wherein the individual components are tritiated randomly in stable positions in proportion to their concentration. This approach to the labelling of complex organic mixtures opens new avenues for radiotracer studies in environmentally important areas.

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190207

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractThe preparation of [14C]tamoxifen from [U‐14C]bromobenzene is described. Several preparations of the compound have been made with overall radiochemical yields of 12% ‐ 14%, and specific activities 1.3 to 10.1 mCi/mmol have been obtained.The purification procedures used, including the separation of thecis‐transisomers by preparative thin layer chromatoqraphy, are also desc

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190208

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractThe preparation of the title compound from 2‐deoxy‐D‐manno‐heptose with potassium [14C] cyanide followed by subsequent oxidation is reported. Frequent use of HPLC has made it possible to follow and optimize the different reaction steps. The synthesis was carried out on the millimole level and the product had a specific activity of 50 m

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190209

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractTritium labelled amitriptyline (1) of high specific activity was prepared. The tritium was incorporated by catalysed isotope exchange into the precursor dibenzosuberone, which had been previously converted into a cyclic ketal, in order to protect the oxo‐group against reduction. It was demonstrated by degradation that isotope exchange occurred exclusively in specified positio

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190210

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractThe gamma‐radiolysis of aqueous solutions of the peptide hormone angiotensin II‐amide and the beta‐autoradiolysis of its tritiated preparations were studied. The radiation loss and the decrease of biological activity of angiotensin II‐amide was evaluated. The main fractions of radiation products were separated and compared with the products formed during the storage of tritiated angiotensin II‐amide. The principal radiation processes taking place during the irradiation of angiotensin II‐amide wer

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190211

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY