摘要:

AbstractA synthesis of 3‐cyano‐4‐methyl‐5 (14C)‐methyl‐2‐(5‐14C)pyrrolyloxamic acid is described. The compound, having specific activity of 66.7 μCi/mmole, was obtained in 19.68% overall yield from uniformly label

ISSN:0362-4803    

DOI:10.1002/jlcr.2580160602

出版商:John Wiley&Sons, Ltd.    

年代:1979

数据来源: WILEY

摘要:

AbstractThe synthesis of DL‐2‐amino‐3‐methyl‐13C‐butanoic‐3,4‐13C3acid (DL‐valine‐13C3) is described. Acetonitrile‐2‐13C was converted to 2‐methyl‐13C‐2‐thiazoline, which was dialkylated with methyl‐13C iodide to give 2‐(isopropyl‐13C3)‐2‐thiazoline. Subsequent reduction and hydrolysis of the isopropylthiazoline afforded 2‐methyl‐13C‐propanal‐2,3‐13C2, which was isolated as the bisulfite addition product. A modified Strecker synthesis with the bisulfit

ISSN:0362-4803    

DOI:10.1002/jlcr.2580160603

出版商:John Wiley&Sons, Ltd.    

年代:1979

数据来源: WILEY

摘要:

AbstractSpecific [2H] and [3H]labelled methyl‐hydroxylated derivatives of 7,12‐dimethylbenz[a]anthracene (DMBA), 7‐hydroxymethyl‐12‐methylbenz[a]anthracene, 7‐methyl‐12‐hydroxymethylbenz[a]anthracene, and 7,12‐dihydroxymethylbenz[a]anthracene, were synthesized with good yield and high specific activity. The method involved two simple steps; oxidation of the unlabelled methyl‐hydroxylated DMBA to the corresponding formyl derivatives followed by reduction with either sodium borodeuteride or sodium borotriteride to yield the [2H] or [3H]labelled methyl‐hydroxylated derivatives with the isotope specifically attache

ISSN:0362-4803    

DOI:10.1002/jlcr.2580160604

出版商:John Wiley&Sons, Ltd.    

年代:1979

数据来源: WILEY

摘要:

AbstractDimethylsulfide‐d6has been prepared in higher yield than reported previously by an improved method involving the reduction of dimethylsulfoxide‐d6with triphenylphosphine in a solvent mixture of carbon tetrachloride and 2,2‐dimethoxydiethyl ether at 0°C. The high isotopic purity of the compound was demonstrated by its gas phase infrared and mass spectra. Its utility as a ligand in coordination chemistry was then shown by the synthesis of two typical gold complexes,viz., chloro(dimethylsulfide‐d6)gold(I) and trichloro(dimethylsulfide‐d6

ISSN:0362-4803    

DOI:10.1002/jlcr.2580160605

出版商:John Wiley&Sons, Ltd.    

年代:1979

数据来源: WILEY

摘要:

AbstractThe photosynthetic preparation of D‐galactose‐13C6and glycerol‐13C3fromGigartina corymbiferais described. The red marine algae biosynthesize the galactoside 2‐hydroxy‐1‐(hydroxymethyl)ethyl α‐D‐galactopyranoside (galactosylglycerol) during photosynthesis. The galactoside was isolated from an alcohol extract by an acetylation procedure and hydrolyzed to D‐galactose and glycerol. The average enrichment of the isolated products was 55 mol %13C while the actual enrichment of newly synthesized material, determined by13C nmr, was 80 mol %13C after a photosynthetic period of 48 hr during which 90 mol %13CO2was administered. Thirty percent of the administered carbon was recovered in the products. The distribution of13C in the galactose and glycerol was shown to be

ISSN:0362-4803    

DOI:10.1002/jlcr.2580160606

出版商:John Wiley&Sons, Ltd.    

年代:1979

数据来源: WILEY

摘要:

AbstractThe synthesis of the14C labelled peptide glycyl‐L‐leucyl‐[14C(U)] glycyl‐L‐proline (I) with the specific activity of 50 μCi/mMole was performed by the Merrifield solid phase method. The peptide (I) was degraded by Achromobacter iophagus c

ISSN:0362-4803    

DOI:10.1002/jlcr.2580160607

出版商:John Wiley&Sons, Ltd.    

年代:1979

数据来源: WILEY

摘要:

AbstractLa synthèse d'un dérivé du Practolol marqué par125I est décrite. En vue d'études métaboliques et pharcocinétiques, nous avons préparé le di125I practolol avec un rendement de 11 % et une activité spécifique de

ISSN:0362-4803    

DOI:10.1002/jlcr.2580160608

出版商:John Wiley&Sons, Ltd.    

年代:1979

数据来源: WILEY

摘要:

AbstractLe chlorure de l'acide chloracétique(1‐14C a été obtenu, avec de bons rendements, par réaction d'échange entre le chlorure de benzoyle et l'acide chloracétique‐[1‐14C]. L'acylation de l'[(amino‐4 phénoxy)‐l, isopropylamino‐3, propanol‐2], par Ie réactif ainsi préparé a permis d'obtenir Ie Chloropractolol [1‐14C]avec une activité spécifique de 230 μCi/mmole. Nous décrivons également la synthèse du Chloropractolol deutérié et tritié (Activité Spécifique : 6,1 mCi/mmole) sur la position

ISSN:0362-4803    

DOI:10.1002/jlcr.2580160609

出版商:John Wiley&Sons, Ltd.    

年代:1979

数据来源: WILEY

摘要:

AbstractL 'adiphénine a été marquéé en deux positions par14C ‐ sur la partie éthanol amine par l'intermédiaire d'éthanolamine14C ‐ sur le groupe carboxyle à l'aide de dioxyde d

ISSN:0362-4803    

DOI:10.1002/jlcr.2580160610

出版商:John Wiley&Sons, Ltd.    

年代:1979

数据来源: WILEY

摘要:

AbstractGibberellin GA3was prepared in low yield but at high specific activity (6.68 Ci/mmol) by platinum catalyzed exchange with tritiated water at 80°C for 16 hours

ISSN:0362-4803    

DOI:10.1002/jlcr.2580160611

出版商:John Wiley&Sons, Ltd.    

年代:1979

数据来源: WILEY