摘要:

AbstractA four‐step synthesis of 1‐decene‐2‐13C starting with 1‐bronooctane (57% overall yield) is

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210902

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

Abstractα‐Methylstyrenes with all three side chain carbons specifically14C‐labelled have been synthesised by Wittig reactions between the appropriately labelled acetophenones or methylene triphenylphosphoranes. The yields in all cases were good and any radiochemical impurities could be readily removed by distilla

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210903

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractNH2OH was labeled with a β+emitter (13N, t1/2= 9 96 min.). Hydroxyl[13N]amine was synthesized from HSO 3−and [13N]nitrite (produced via the160(p,α)13N reaction by proton bombardment of H2O). The synthesis reactions are:Hydroxyl[13N]amine was purified by ion‐exchange chromatography on Dowex‐1 × 8 (AcO−) to remove unreacted13NO 2−and13NO 3−. Radiochemical yields of 50–90% were obtained in 25–30 min. The purity and specific activity of13NH2OH were determined by HPLC analysis and spectrophotometric assay. The binding of13NH2OH to pig heart glutamate‐pyruvate transaminase and to pig heart glutamate‐oxaloacetate transaminase was measured. This work demonstrates that quantitation of the binding of hydroxylamine (an active‐site directed enzyme inhibitor) labeled with a positron‐emitting

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210904

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractWe report the synthesis of11C‐labelled choline using the reaction of “nocarrier‐added”11C‐labelled methyliodide and 2‐amino‐(N,N‐dimethyl)‐ethanol. After determining the optimum temperature and duration for the reaction, we achieved a radiochemical yield of about 30% and the radioactivity levels needed for PET

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210905

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractA novel method for the radioiodination [131I] of the multicomponent non‐ionic surfactant nonoxynol‐9 (N‐9) is described. The extent of incorporation and distribution of the131I‐label into the aromatic moiety of various ethoxymer units of N‐9 was determined utilizing a high pressure liquid chromatographic (HPL

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210906

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe syntheses of D,L‐1‐amino[2,2‐2H2]cyclopropane‐1‐carboxylic acid; 1‐amino [c‐2,c‐3‐2H2] and 1‐amino[t‐2,t‐3‐2H2]cyclopropane‐1‐carboxylic acid (cis‐[2H2]ACC); 1‐amino[2S,3S‐2H2] and 1‐amino[2R,3R‐2H2]cyclopropane‐1‐carboxylic acid (trans‐[2H2]ACC); and 1‐amino[2,2,3,3‐2H4]cyclopropane‐1‐carboxylic acid are described. The [2,2‐2H2]and [2,2,3,3‐2H4]ACC compounds were prepared from the appropriately deuterated 2‐bromoethanol 4‐methylbenzenesulfonates by reaction with ethyl isocyanoacetate and two moles of sodium hydride. Thetrans‐[2H2]ACC andcis[2H2]ACC were prepared frommesoandd, l‐[1,2‐2H2]‐1,2‐dibromoethane respectively, by reaction with ethyl isocyanoacetate and two moles of sodium hydride. These compounds are required for use in the study of the biosynthesis of ethylene by various plants and for use in1H

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210907

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

Abstract17‐I‐123‐heptadecanoic acid is prepared carrier‐free from 17‐Br‐heptadecanoic acid in methyl ethyl ketone at 100°C. A quantitative labeling yield is obtained within 20 minutes using a 50 KHz ultrasonic bath. Sonication allows the presence of water up to 7.5% v/v. The pattern shown by the plot of the kinetic curves is typical of two consecutive reactions: the first being the dissociation of a radioactive side product, the second a I−for Br nucleophilic exchange. The pure carrier‐free radioiodinated fatty acid is obtained by HPLC separation and is used clinically in a sterile 6% human serum albumine solution. The quality control of the injection ready solution is based on the use of a RP18 S

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210908

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe preparation of [3H]‐clomiphene and [3H]‐nitromiphene from amido precursors in a two‐step reaction sequence utilizing NaB H4is described. The radiochemical yield and specific activity of the former are 34% and 16 mCi/mmol and those of the latter were 42% and 20 mCi/mmol, respectively. The method described is of micromolar scale designed for maintaining cost economy in the purchase of expensive radiolabelled reagents while yielding final products of sufficient radioactivity forin vitroandin vivometabolism st

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210909

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractA rapid synthesis of 5′‐deoxy‐5‐[18F] fluorouridine (3a) from either [18F] F2or CH3CO218F is described. Fluorination of 2′,3′‐di‐O‐acetyl‐5′‐deoxyuridine (1a) with either [18F] F2or CH3CO218F in glacial acetic acid at room temperature followed by hydrolysis with sodium methoxide in methanol gives 5′‐deoxy‐5‐[18F] fluorouridine (3a) in radiochemical yields of 20‐25% in a synthesis time of 80 min from EOB. The same method also has been used to synthesize 5‐[18F] fluorouridine (3b) and 2′‐deoxy‐5‐[18F] fluorouridine (3c) in similar radiochemical yields. Acetyl hypofluorite (CH3CO2F) is prop

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210910

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractA three‐step synthesis of the neuroleptic benperidol is presented, and the rapid no‐carrier‐added (n.c.a.) radiobromination of this compound to form brombenperidol (BBP), a radiolabelled dopaminergic receptor‐binding ligand, is described. N.c.a. radiobromination of benperidol using dichloramine‐T in trifluoroacetic acid at elevated temperatures results in bromination totally at the benzimidazolinyl ring of the neuroleptic, leaving the molecular characteristics necessary for receptor binding unaltered. Radiopharmaceutical production results in n.c.a.75,77Br‐brombenperidol with a corrected radiochemical yield of 30% and a specific activity exceeding 8,

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210911

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY