摘要:

Abstract[4″‐3H]‐2‐(1‐[2″,6″‐Dichlorophenoxy]‐ethyl‐Δ2‐imidazoline) was prepared from [4‐3H]‐2,6‐dichlorophenol in two different ways. By reaction of 2,6‐dichlorophenol with 2‐(α‐chloroethyl)‐Δ2‐imidazoline, the radiochemical yield, at a specific activity of 173.9 mCi/mmole, was 12.8 %. With the two‐step‐procedure (reaction of 2,6‐dichlorophenol with 1.) 2‐chloropropionitrile and 2. ethylenediamine, the radiochemical yield of product, at a specific activity of 185.8 mCi/mmole, was 30.0 %.[4,4,5,5‐2H4]‐2‐(1′‐[2″,6″‐Dichlorophenoxy]‐ethyl)‐Δ2‐imidazoline was

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180302

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractGlucosamine, galactosamine and mannosamine react with ferrocene‐ or ruthenocene‐carbaldehyde, respectively to yield the corresponding Schiff's bases, which are reduced at the CN‐bond and at the aldehyde function of the sugar moity. With14C‐labelled amino‐sugars or103Ru‐labelled ruthenocene‐carbaldehyde the labelled aminohexite compounds of the metallocenes

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180303

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractA method for the production of13NN either as a gas or as an injectable solution is described. The method is based on the16O(p,α)13N reaction and water as target material. Following irradiation, the13NO 2−and13NO 3−are reduced to13NH3, followed by NaOBr oxidation to13NN. With a beam current of 1 μA and 20 min irradiation time the injectable solution contained 148 MBq (4 mC

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180304

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

Abstract[5‐14C]‐ and [4,5,6‐14C] glucose were prepared from [2‐14C]‐ and [U‐14C] glycerol and fructose 6‐phosphate by reactions involving the enzymes glycerokinase, glycerol 3‐phosphate dehydrogenase, triose phosphate isomerase, transaldolase, lactate dehydrogenase and phosphoglucose isomerase. The authenticity of each of the14C‐labelled sugars was verified by chromatographic and enzymic procedures and the distribution of14C isotope confirmed by specific degradative procedures. These specifically labelled substrates are required for the quantitative estimation of the new pentose pathway reactions in liver, photosynthetic and so

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180305

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe synthesis of d, l, ‐12‐bromocamptothecin (2d) from camptothecin (1) is described. Reduction of the bromo derivative2dwith tritium gas in the presence of palladium on carbon afforded d, l‐camptothecin 12‐3H having a specific activity of 29 Ci/mmol. A simpler labelling procedure was subsequently discovered whereby deuterium in the presence of palladium on carbon reduced ring B of camptothecin and also exchanged the C‐5 hydrogen with deuterium. The reduced camptothecin aromatized to camptothecin in the presence of air to give deuterium incorporation in the C‐5 and C

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180306

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe 2 + 4 cycloaddition reaction of 1,4‐naphthoquinone and substituted styrenes was used to prepare 1‐, 2‐, 3‐, and 4‐bromobenz[a]anthracene‐7,12‐diones (BADs). The corresponding bromobenz[a]anthracenes (BAs) were prepared by aluminum tricyclohexoxide reduction of the diones. Lithiation witht‐butyllithium followed by quenching with deuterium oxide gave the specifically2H‐labeled BAs with deuterium incorporations of>95%. The 2‐, 3‐, and 4‐bromo‐7,12‐dimethylbenz‐[a]anthracenes (DMBAs) were prepared from the bromo BADs in moderate yield by the classical Grignard procedure. Lithium aluminum deuteride reduction gave the2H‐DMBAs. An alternate synthesis from 3,4‐dihydrobenz[a]anthracene 1‐(2H)‐one was used for the pre

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180307

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe anion of N,N‐dibenzylglycine ethyl ester was condensed with acetone to afford N,N‐dibenzyl‐β‐hydroxyvaline ethyl ester which was debenzylated and hydrolyzed to yield β‐hydroxyvaline in 72% overall yield. A variety of β‐hydroxyvalines labelled on the isopropyl group can be prepared by this procedure as shown by the preparation of [4,4′‐2H6]‐β‐hydrox

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180308

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractIndium‐111 mesoprotoporphyrin IX has been prepared by refluxing suitable proportions of InCl3, sodium acetate, and mesoprotoporphyrin IX in glacial acetic acid. The labeled metalloporphyrin is sufficiently water‐soluble for use as a scanning agent, and can also be incorporated into heme apoproteins for perturbed gamma‐gamma angular correlation measure

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180309

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe synthesis of [11β‐3H]prostacyclin and [11β‐3H]6‐oxo‐prostaglandin F1αhas been described. The strategy involved borotritide reduction of prostaglandin D2, followed by cyclic iodoether formation. Adenylate cyclase activation in a neuronal somatic cell hybrid and GC‐MS were used for the analysis of the target compounds. The ready acid catalysed ketal formation of [11β‐3H]6‐oxo‐prosta

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180310

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractPerdeuterio‐N‐(1‐oxyl‐2,2,6,6‐tetramethyl‐4‐piperidinyl)‐maleimide has been prepared to improve sensitivity and resolution in its ESR spectrum. The synthesis involved modifications of procedures known for the corresponding protonated analog. Spectral data are presented for the product to establish isotopic purity. A five‐fold enhancement of the ESR signal for the title compound relative to the proton counterpart

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180311

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY