摘要:

AbstractTritiation of the delta‐specific opioid alkylating ligand FIT,3and the mu‐specific opioid alkylating ligand BIT,9to high specific activity is described. Both compounds were derived from dibrominated amino intermediates (4and10, respectively) which were tritiated with tritium gas over Pd/C before conversion of the amine functions to isothiocyana

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210802

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

Abstract17‐β‐Estradiol has been labeled in the 2 or 4 position with tritium or deuterium. Both 2‐ and 4‐iodoestradiol were prepared by treatment of estradiol with N‐iodosuccinimide in ethanol followed by chromatographic separation. Reductive dehalogenation of 2‐ and 4‐iodoestradiol with tritium gas gave [2‐t] estradiol and [4‐t]estradiol, respectively, with specific activities of approximately 2 Ci/mmole. Greater than 99% of the radiolabel was incorporated into the target positions as determined by rehalogenation of the radiolabeled compounds. Analysis of the deuterium labeled compounds, [2‐d] estradiol and [4‐d]estradiol, similarly prepared by reduction with deuterium gas, revealed that isotope incorporation

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210803

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractA simple one‐step syntheses of 2‐([14C]‐methyl) furan and 4‐oxo‐[5‐14C]‐2‐pentenal have been described. Carbon‐14 labeled 2‐methylfuran was synthesized by treatment of 2‐furyl lithium with14C‐methyl iodide, and14C‐acetylacrolein was obtained by peracid oxidation

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210804

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractAlkylation of the dianion of 3‐(phenylsulfinyl) propanol with [13C] iodomethane and subsequent reductive fission of the sulfoxides gave [4‐13C] butanol that was oxidized to give [4‐13C] butanoic

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210805

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractSyntheses of (2,3‐13C2) piperidine and (1,2‐13C2) granatanine via (1,2‐13C2)‐glutaric acid have been achieved using a benzene ring as a potential carboxy

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210806

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractAlkylation of diethyl oxalpropionate with [D3]methyl iodide followed by acid hydrolysis led to 3‐[D3]methyl‐2‐oxobutyric (α‐ketoisovaleric) acid. Alkylation of N‐t‐butylpropylimine with [D3]methyl iodide followed by hydrolysis gave 2‐[D3]methylpropanal. This was further alkylated with 2,2‐difluoro‐1‐tosyloxyvinyllithium and hydrolyzed to afford 4‐[D3]methyl‐2‐oxopentanoic (α‐ketoisocaproic) acid. Diazotization of [1‐13C]leucine ethyl ester with t‐butylnitrite followed by peracid oxidation and hydrolysis gave [1‐13C]4‐methyl‐2‐oxopentanoic acid. In each case, the

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210807

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractA remote system has been constructed for the preparation of11C‐glucose via photosynthesis. The system is totally contained in a shielded hood, with all manipulations done from the outside. This system is capable of routine delivery of 25–50 mCi of11C‐glucose which has a radiochemical purity>95% and is sterile and pyrogen free. The design, construction and operation of this system are fully desc

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210808

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractA convenient method for preparing 5H‐2,3‐benzodi‐azepines labelled with14C was developed in which the corresponding phenylacetone derivatives were acylated by labelled aromatic carboxylic acid. In spite of the low yield, this method is advantageous in comparison the known ones because of the obtainable specific activity, which is a consequence of the few stages and simplicity of the synt

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210809

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe synthesis of the epimeric 2‐bromocholesterols is described. Their reductive catalyzed debromination with T2affords [2α‐3H]‐ and [2ß‐3H]cholesterol respectively. The [2‐3H] cholesterols can be synthesised with a radiochemical purity>98% and specific activities of about 600–700 GBq/mmol. The labelling reactions proceed un

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210810

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractAn investigation has been carried out to evaluate the quantity of stable nuclides of bromine that might be introduced into the reaction mixtures of high specific activity radiobrominations from the reagents used. In the investigation neutron activation analyses were performed on the radionuclide solutions, solvents, oxidizing agents, and substrates that have been used in radiobromination reactions to determine the concentrations of bromine present. All of the reagents examined had detectable quantities of bromine. Among the reagents, a large variation in the concentrations of bromine was found. Due to the quantities of bromine found and the variability of bromine concentrations in the reagents, it is suggested that the reagents used in high specific activity radiobrominations be analyzed for bromine.

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210811

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY