摘要:

AbstractThe synthesis of the tritiated sex pheromone of the saturniid mothAntheraea polyphemuswas accomplished by stereospecific T2reduction of (E)‐hexadec‐6‐en‐11‐yn‐1‐yl acetate. The [11, 12‐3H2]‐(E, Z)‐6, 11‐hexadecadieny 1 acetate was then converted to the corresponding diazoacetate, a behaviorally active photoaffinity label for theA. polyphemuspheromone binding and receptor proteins. Synthesis of the enyne precurs

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210702

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractA series of iodinatable water soluble polyethylene glycol (PEG) derivatives were prepared for use as model hydrophilic drugs. Polyethylene glycol diamine 6000 was coupled to methylp‐hydroxybenzimidate, and PEG 1900‐ and PEG 5000‐monomethyl ethers were coupled to tyramine and histamine. The derivatives underwent facile iodination with the chloramine‐T reaction and were stable under a wide range of conditions. The larger derivatives showed rapid renal clearance, but the 1900 MW compounds underwent significant clearance via t

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210703

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractDeuterium labeled bile acids are synthesized from their keto acid analogs by a one‐pot base‐catalyzed enolization exchange with deuterated hydroxylic solvents (OD) followed byin situreduction of the ketone. The stereochemistry of the alcohol, especially that at C‐7, can be controlled either by steric approach reduction with sodium borodeuteride or thermodynamically by reduction with sodium inn‐

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210704

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThis paper describes a general, simple and short procedure for the introduction of stable isotopes (deuterium and carbon‐13) to the side chain of bile acids. The bisnorcholyl aldehydes of cholic and chenodeoxycholic acids are key intermediates, while the isotope is introduced by the Wittig condensation of [1,2‐13C2]‐(carbethoxymethylene)triphenyl‐phos

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210705

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

Abstract7‐methoxy −2‐nitro naphto [2,1‐b] furan was 14 labelled by C on two positions:—on the position one of the furan ring starting with sodium formiate—on the methoxy group by means of me

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210706

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractWe describe the synthesis of deuterated diethylstilbestrol isotopomers, starting from commercially available ketones. Attempts to synthesizeE‐3,4‐di‐(4‐hydroxyphenyl) hex‐3‐ene‐2,2,5,5‐2H4from 4‐methoxypropiophenone were not successful. Starting from 4‐methoxyacetophenone, isotopically pureE‐3,4‐di‐(4‐hydroxyphenyl)hex‐3‐ene‐1,1,1,6,6,6‐2H6was obtained. The 3‐steps synthesis involved alkylation of the ketone with iodomethane‐1,1,1‐2H3, reductive coupling with titanium trichloride‐lithium reagent, and demethylation with trimethylsilyliodide. The possible use of the hexadeuterated diethylstilbestrol in isotope

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210707

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractHere, we report the synthesis of high specific activity tritiated 2‐trifluoroacetamidobenzenesulfonyl fluoridea potent elastase inhibitor. Preparation of a ring iodinated precursor followed by palladium on CaCO3catalyzed deiodination with deuterium and tritium gas afforded high levels of isotope incorporation in both case

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210708

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe synthesis of the 3‐hydroxyphenyl and 4‐hydroxyphenyl metabolites of 5,5‐diphenylhydantoin (Phenytoin) labelled with deuterium in either of the two phenyl rings and 5(4‐hydroxy‐[2H4]phenyl)‐5‐[2H5] phenylhydantion

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210709

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractAqueous solutions of histamine and imidazole were gamma‐irradiated in the absence and presence of ethanol. The protective effect of ethanol on the radiation cleavage of the imidazole ring depends on the pH of irradiated solutions: at neutral pH the presence of ethanol decreases radiation degradation of imidazole skeleton whereas at acidic pH it does not play any protective role. On the contrary in irradiated aqueous‐ethanolic solutions of histamine 2 HCl (pH 4.5) some additional reactions between histamine and products of radiolysis of ethanol, mainly with acetaldehyde, take place leading to the increase of total radiation loss of histamine and to the formation of further radiation products. Similar products were also found in3H preparations of histamine stored in aqueous‐ethanolic solutions. Possible mechanisms of radiation degradation of histamine were disc

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210710

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210711

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY