摘要:

AbstractA procedure for the facile preparation of labelled carboxylic acids from labelled α‐amino acids has been described. The reaction is attractive for the small scale synthesis of such compoun

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190802

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractThe decay technique, currently applied to the study of ionic processes in gaseous and liquid systems, requires multitritiated precursors to generate labeled daughter ions. The preparation of three such precursors, namely C63HxH6−x, C63HxH5−xCH3, and C6H5C3H3−xis described. The ring–labeled precursors were obtained from the cyclization of C23H2, and respectively of a C23H2/propyne mixture, carried out at 25°C over a K2CrO4–promoted silica–alumina catalyst. The side–chain tritiated toluene was prepared by allowing3H2O and benzotrichloride to react over a Zn mirror at 200°C. Details of the procedures employed for the radiometric and the isotopic analysis of the multilabeled produc

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190803

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractA simple method is described for the preparation of 2‐[125I]iodohistamine‐labelled Δ8‐tetrahydrocannabinol‐11‐oic acid with high specific activity for use in radioimmunoassay. This compound is produced in high yield and shows excellent radiochemical stability when stored at 4°C. The radiolabelled cannabinoid has been shown to bind avidly to four different broadly specific cannabinoid antisera. It is the only [125I] labelled cannabinoid suitable for use in radioimmunoassay with su

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190804

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractA facile method for the preparation of18O labeled ara‐C and ara‐U is described. The method provides a means of incorporating18O specifically at the 2‐position of the nucleobase. The site and level of label was established using mass spectro

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190805

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractA procedure for the preparation of a radioiodinated derivative of ganglioside GM1has been devised. Carbon 6 of the terminal galactosyl residue of GM1was converted to an aldehyde by galactose oxidase. The adduct formed by this oxidation product of GM1with tyramine was reduced with sodium cyanoborohydride. The tyramine moiety covalently attached to GM1was then labelled by the conventional iodine chloride procedure. The technique described herein is simple and economical for the preparation of a highly radioactive GM1derivative.

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190806

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractAlkylation of ethyl acetoacetate‐13C4with ethylene oxide and ethylene oxide‐13C2afforded 2‐acetylbutyrolactone‐13C4(4a) and the hexalabeled form (4b), respectively. Treatment of the lactone with an excess of 48% hydrobromic acid effected decarboxylation with bromide displacement to yield 5‐bromo‐2‐pentanone labeled with 3 or 5 carbon‐13 atoms (5). The bromo ketone was converted to the ethylene ketal with ethylene glycol andp‐toluenesulfonic acid catalysis. Displacement of the bromide by sodio diethyl phosphite gave the required ethylene ketals of 5‐(diethylphosphono)‐2‐pentanone (7). A convenient process for preparation of ethylene‐13C2oxide from acetic

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190807

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractA tacile synthesis of 2‐nitrobenzaldehyde‐formyl‐13Cwas developed. This compound was converted to the labelled antiarrhythmic agent, encainide‐13Chydrochloride, 4‐methoxy‐N‐[2‐[2‐(1‐methyl‐2‐piperidinyl)ethyl‐1‐13C]phe

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190808

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractA nine‐step preparation of 4‐iodo‐2‐methyl‐1‐butene‐1,1‐d2(9) from 2‐methylbutyrolactone

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190809

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

Abstract3,4,5‐Trimethoxy‐2H9‐, 4‐methoxy‐3,5‐dimethoxy‐2H6‐, and 4‐hydroxy‐3,5‐dimethoxy‐2H6‐benzoic acids were prepared fromn‐propyl 3,4,5‐trihydroxybenzoate (n‐propyl gallate) by means of appropriate alkylation‐hydrolysis sequences employing iodomethane‐2H3or dimethyl‐2H6‐sulfate as the deuterium source. 4‐Methoxy‐2H3‐3,5‐dimethoxybenzoic acid was similarly prepared from ethyl 4‐hydroxy‐3,5‐dimethoxybenzoate. The labeled trimethoxybenzoic acids were converted to the corresponding2H‐labeled reserpines by condensation of the acid chlorides with methyl reserpate in pyridine according to the classical procedure. The labeled reserpine analog methyl 18‐O‐(4‐hydroxy‐3,5‐dimethoxy‐2H6)benzoyl reserpate was likewise prepared from 4‐hydroxy‐3,5‐dimethoxy‐2H6‐benzoic acid via the intermediate methyl 18‐O‐(4‐ethoxycarbonyloxy‐3,5‐dimethoxy‐2H6‐benzoyl)res

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190810

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

Abstract7‐Chloro‐5‐(2‐chlorophenyl)‐1,3‐dihydro‐2H‐1,4‐benzodiazepin‐2‐one labeled with carbon‐14 in carbon 5 of the diazepine ring has been synthesized. The compound was prepared in a multistep synthesis from barium carbonate‐14C i

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190811

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY