摘要:

AbstractThe synthesis of stabilized tritium‐labelled 2‐monoglycerides which may be used as lymphatic absorption adjuvants, using [carbonyl‐3H]‐benzaldehyde is described. A simple method of analysis for the regeneration of these compounds from their stabilized forms is also p

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210602

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

Abstract1‐Acyl‐2‐[9,10‐3]oleoyl‐sn‐glycero‐3‐phosphorylcholine was prepared by acylating 1‐acyl‐sn‐glycero‐3‐phosphorylcholine with labelled oleic acid, in the presence of dicyclohexylcarbodiimide (DCC), as condensing agent. A simple column chromatographic procedure allowed both purification of the labelled phospholipid and recovery of the unreacted oleic acid, at the end of the reaction. In standard conditions, yields of 35–40 % were obtained.The major feature of this procedure is that it is a “one pot” reaction not requiring the isolation of an activated acid derivative prior to esterification.This method is also suitable for preparing labelled phospholipids other than phosphatidylcholine, provided that free or unmasked amino or hydroxyl gr

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210603

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractBy condensing diethyl ethoxymethylenemalonate with diethyl acetamidomalonate, 5‐hydroxy‐2,4‐dicarbethoxypyrrole was prepared. Hydrogenation over Pt‐C to 5‐oxo‐2,4‐dicarbethoxypyrrolidine, followed by alkaline hydrolysis gave γ‐carboxyglutamate. Mild alkaline hydrolysis yielded 5‐oxo‐2,4‐pyrrolidine dicarboxylic acid which was isolated as the cyclohexylamine salt. These procedures were applied to prepare tritium‐labeled γ‐carboxyglutamic acid (4.9 Ci/mmol) and it

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210604

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractBy an improved synthesis, 5‐hydroxy‐6‐methyl‐2‐di‐n‐propylaminotetralin (DK‐118), a dopamine agonist, has been obtained in only six steps and in greater than 10% overall yield. This new synthesis has been used for the preparation of 5‐hydroxy‐[6‐14C]‐methyl‐2‐di‐n‐propylaminotetralin (I) to be used in metabolic studies. The14C‐radiolabel was introduced near the end of the synthesis by an ortho‐specific formylation

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210605

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractCarbonylation of 1‐undecene with13CO under a hydrogen atmosphere with palladium‐stannous chloride catalyst afforded [1‐13C]dodecanoic (lauric) acid on a 0.25 mole scale. Reduction to the alcohol and treatment with concentrated HBr gave 1‐[1‐13C]bromododecane which was used to alkylate the Na+, Li+mixed diananion of ethyl acetoacetate selectively at the 4‐position in 73% yield. Reductive deoxygenation of the resulting 3‐oxo intermediate, followed by saponification and purification, gave [1,2,3,4,5‐14C5]hexadecanoic (palmitic) ac

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210606

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractNo‐carrier‐added (NCA) [18F]fluorobenzene was prepared in a multistep synthesis with a radiochemical yield of 20‐30%.A series of NCA and CA18F‐labeled aryl fluorides which are important precursors of18F‐labeled butyrophenone neuroleptics have also been synthesized in radiochemical yields of 30–50%. The direct synthesis of [18F]spiroperidol and [18F]benperidol from the parent compounds and/or nitro and/or chloro compound using the nucleophilic substitution reactions were also i

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210607

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe synthesis of [14C‐carboxyl] 1,8‐naphthalic anhy‐anhydride of high specific activity (31.8 mCi/mmol) is reported. The14C was introduced by carbonation of the Grignard reagent, 8‐bromo‐1‐naphthylmagnesium iodide, that was prepared from 8‐bromo‐1‐iodonaphthalene. The overall radiochemical yield for the reaction scheme was 63.7% based on bar

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210608

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractThe syntheses of D,L‐[3,3,4,4‐2H4]methionine from [2,2,2‐2H3] acetic acid in seven steps in an overall yield of 26% and L‐[4,4‐2H2]methionine fromN‐t‐BOC‐L‐aspartic acid α‐benzyl ester in five steps in an overall yield

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210609

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractSyntheses of specifically labelled [15N,15N′]‐ and [4,4′‐13C2]‐4,4′‐dichloroazobenzene and [15N,15N′]‐4‐chloroazobenzene hav

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210610

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY

摘要:

AbstractCI‐9212, a potent antitumor agent has been labeled with deuterium and tritium by an exchange reaction employing platinum black as a catalyst. The title compound was carbon‐14 labeled from 2‐chloro‐benzoic‐carboxy‐14Cacid to produce the isethionic salt2dwith a specific activity of 26.9 mCi/mmol. The overall radiochemical yield for the carbon‐14 seq

ISSN:0362-4803    

DOI:10.1002/jlcr.2580210611

出版商:John Wiley&Sons, Ltd.    

年代:1984

数据来源: WILEY