摘要:

AbstractStarting from 3‐(2‐deoxy‐β‐D‐erythro‐pentofuranosyl)‐6,7‐dihydroimidazo[4,5‐d][1,3]diazepin‐8(3H)‐one (4), the synthesis of both the R‐and S‐isomers of [8‐3H]pentostatin has been achieved. The separation of the desired R‐isomer inCa. 24% overall chemical yield from the R, S‐mixture was effected by preparative reverse‐phase chromatography utilizing a C18 stationary support. Crystalline product of high specific act

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180702

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe progress that has been made in incorporating the short‐lived, positron‐emitting isotopes N‐13 and C‐11, into biologically active compounds by biosynthetic means is reviewed. These methods include the use of whole cells or plant leaves to carry out a sequence of metabolic reactions, such as nitrogen fixation or photosynthesis, and the use of purified enzymes to catalyze specific chemical reactions, to form the labeled co

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180703

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractIncorporation of tritium into selected polar solvents was studied in the presence of bases and buffering substances. Tritium gas was used as a tritium source and the, reaction was catalyzed by PdO, Pd/BaSO4, Raney nickel.

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180704

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe title compound was obtained by preferential crystallisation of (2RS,5R)‐[5‐2H]proline. The labelled racemic amino acid was synthesized in five steps from (5R)‐[5‐2H]‐2‐pyrrolidone, which was prepared by cyclisation of (4R)‐[4‐2H] GABA. The stereospecific label was introduced into GABA enzymatically decarboxylating in2H2O (2S)‐glutamic acid, in the presence of glutamate decarbox

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180705

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractMethyl iodide‐14C was condensed with 2‐(1‐lithio‐hept‐1‐yn‐6‐yl) 1,3‐dioxolanne4in presence of HMPT and benzene to give 2‐(oct‐2‐yn‐8‐yl‐1‐14C) 1,3‐dioxolanne5.Catalytic reduction of5, followed by acid hydrolysis led to pelargonic aldehyde 9‐14C 7. Condensation of this aldehyde 7 with an excess of w‐carbomethoxy‐tetradecylidene), triphenyl phosphorane11produced methyl nervonate 24‐14C12. The latter was isolated from its trans isomer by chromatography on a silver nitrate impregnated silicagel column. Finally, nervonic acid 24‐14C13was obtained by alkaline hydrolysis (specific activity : 52 mCi/mMole) with an ove

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180706

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe syntheses of 4‐amino‐3,2′‐dimethyl‐biphenyl‐3‐methyl‐14C, a potent carcinogen and mutagen, and 4‐amino‐2′‐methylbiphenyl‐2′‐methyl‐14C, an analogue having weaker activity, are described. In both cases, l

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180707

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe fumarase inhibitor, bromomescaconic acid, has been synthesized with13C labeling in the bromomethyl group. Di‐t‐butyl acetylene‐dicarboxylate was converted with Li (13CH3)2Cu to di‐t‐butyl (methyl‐13C)citraconate. Photochemical isomerization of this to di‐t‐butyl (methyl‐13C)mesaconate, followed by deblocking with trifluoroacetic acid gave t

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180708

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractSyntheses and analyses are described for β‐N‐phenyl [14C(U)]‐L‐asparagine, O‐acetyl [1‐14C]‐L‐serine, O‐benzoyl [7‐14C]‐L‐serine, benzyl[7‐14C]glycinatep‐toluenesulfonate, benzyl glycinate[1‐14C]p‐toluenesulfonate, and α‐

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180709

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe synthesis of indazole‐1‐15N from 2‐nitrotoluene‐15N is described Indazole‐2‐15N has been prepared from 2‐methyl‐4‐nitroaniline and sodium nitrite‐15N through 5‐nitroindazole‐2‐15N. The N‐methyl derivatives of these three i

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180710

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

Abstract(ring‐4,6‐14C) Pentamethylmelamine (14C‐PMM), a new antitumor agent, was prepared from barium (14C) carbonate by a 6 step synthesis. (14CN) Dimethylcyanamide, prepared from sodium (14C) cyanide with 71% yield and treated with phosgene in the presence of hydrogen chloride, was cyclized to (ring‐4,6‐14C)‐2‐chloro‐4,6‐bis (dimethylamino)‐s‐triazine. The latter was purified by silicagel low pressure liquid chromatography (15% yield based on nitrile) and condensed with monomethylamine to give14C‐PMM. After purification14C‐PMM was obtained with 91% yield, specific activity = 38 mCi/mMole. The mechanism of the reaction of nitrile wi

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180711

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY