摘要:

Abstract2,2′,5′,2″– [2′,5′ –14C2] Terthienyl and 1,4–Bis (2–Thienl) [1,4–14C2] butadiyne were synthesized fro

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190302

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractSeveral efficient procedures for the synthesis of deuterium, tritium, and14C–labeled acetaminophen, phenacetin, and p‐acetanisidine are described. p‐Aminophenol was acylated by the appropriate acetic anhydride under mild conditions yielding labeled acetaminophen. With 0‐alkylation using NaCH2SOCH3and appropriate labeled and unlabeled alkyl halides, labeled phenacetin and p‐acetanisidine were also obtained. Phenacetin labeled both with14C on the acyl group and deuterium on the ethoxy group was synthesized in high yield by acylation of p‐phenetidine‐d5. The last compound was obtained by acid hydrolysis of phenacetin‐d5synthes

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190303

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractPhenyl [1‐14C] acetylene (0.012mCi/mmole) was synthesized in 12.5% yield from [1‐14C] acetic acid through [1‐14C] acetophenone, its semicarbazone, and 4‐phenyl‐[4‐14C] 1,2,3‐selenadiazole obtained by selenium dioxide oxidation. Oxidative coupling gave 1,4‐diphenyl [1,4‐14C2] butad

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190304

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractA route to mevinolin () bearing (S)‐2‐methylbutanoic acid ‐1‐14C as the ester side chain has been developed. The structure of mevinolin () was degraded and selectively protected to provide the alcohol in three steps. Incorporation of14C was accomplished by acylation of alcohol with (R,S)‐2‐methylbutyryl chloride‐1‐14C. Cleavage of the silyl ether protecting group in the resulting mixture of esters provided the two diastereoisomers and which were separated by reverse‐phase liquid chromatography. Mevinolin ‐14C () was also converted to the ammonium salt of the correspon

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190305

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractDeuterium and tritium labeled 4,5′,8‐trimethylpsoralen (), psoralen (), and angelicin (), have been prepared by D2O and T2O exchange with specific activities of 228‐253 mCi/mmol. Tritium labeled 4,5′,8‐trimethylpsoralen () with a specific activity of 17.6 Ci/mmol was prepared by catalytic reduction with tritium gas followed by dehydrogenation. Tritiated 4′‐hydroxymethyl‐4,5′,8‐trimethylpsoralen () with a specific activity of 12.0 Ci/mmol was obtained by reduction of the corresponding aldehyde with sodium borotritide and elaborated to 4′‐aminomethyl‐4,5′,8‐trimethylpsoralen () (12.0 Ci/mmol) by conversion of to the chloromethyl derivative followed by the Gabriel synthesis. Tritium labeled 8‐methoxypsoralen () was prepared by demethylation of unlabeled to the phenol followed by methylati

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190306

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractA method is described for the preparation of a barbiturate derivative, 3‐iodo‐4‐hydroxyphenobarbitone, labelled with [125I]iodine. The structure of the compound was confirmed by synthesis and purification of the [127]iodine derivative followed by mass spectral studies. The [125I]iodine labelled barbiturate has proved to be chemically stable and has been shown to bind to a barbiturate antiserum. It should, therefore, prove to be very useful for the development of a radioimmunoassay for barbitu

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190307

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractA method for the production of carboxy‐labelled l‐carnitine is described. The first step is the chemical synthesis of 4‐N‐trimethylammoniobutanoate (butyrobetaine) from the precursors 4‐aminobutanoate and iodomethane. The second step involves the hydroxylation of butyrobetaine to form l‐carnitine using butyrobetaine hydroxylase partially purified from bovine calf liver. The method also can be used to synthesize Me‐labelled and uniformly‐chain‐lab

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190308

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractSynthesis of 2‐acetoxy 4‐trifluoromethyl benzoīc acid [ring U ‐14C] or “[ring U‐14C] Trifusal” U14C)(Ring U‐14C) Aniline1was converted into (ring U‐14C) idobenzene2through the (ring U‐14C) phenyldiazonium chloride. Trifluoromethylation of2with iodotrifluoromethane in presence of copper gave (ring U‐14C) trifluoromethylbenzene3with a 64% yield. Nitration of3with sodium nitrate + trifluoromethane sulfonic acid in dichloromethane gave a 86% yield of (ring U‐14C) 3‐nitro trifluoromethyl benzene4which was reduced by iron and HCl into the corresponding amine5. The latter was transformed into the phenol6with a 85% yield by action of Cu (NO3)2and CuO on (ring U‐14C) 3‐trifluo romethyl phenyldiazonium sulfate. Kolbe reaction of phenol6with carbon dioxide and K2CO3gave7with a 59% yield. Acetylation of7gave (ring U‐14C) Triflusal8with a quantitative yield and a specific activity of 14 mCi/mMole14radiochemical purity 98.5%. The overall yield fr

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190309

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractTritium and14C‐labeled isomers of ethyl acetate are excellent substrates for competitive dual‐labeled radioactive isotopic measurements of β‐deuterium and β‐tritium isotope effects. Methods are given for preparation of the ethyl esters of acetic acid‐2‐3H, acetic acid‐2‐14C, and acetic acid‐2,2‐2H2‐2‐3H, and of the acetic acid ester of ethanol‐l‐14C from the least costly labeled precursors in high purity (yie

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190310

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY

摘要:

AbstractConvenient and efficient syntheses of13C and2H sidechain labelled L‐tryptophan, racemic 5‐hydroxytryptophan and 5‐hydroxytryptamine (serotonin) from indole and 5‐benzyloxyindole are de

ISSN:0362-4803    

DOI:10.1002/jlcr.2580190311

出版商:John Wiley&Sons, Ltd.    

年代:1982

数据来源: WILEY