摘要:

AbstractThe synthesis of14C‐labelled poly(ℓ‐menthyl isopropenyl carbonate) is described. Experimental conditions are included for incorporation of14C into each of the carbon atoms in the molecule. High pressure liquid chromatography conditions are given for separation and purification of the labelled intermed

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180602

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractNG‐Mono[14C‐methyl]‐L‐arginine was prepared in a two‐step synthesis. N,S‐dimethylthiopseudouronium iodide [methyl‐14C] was prepared in excellent yield and afforded the labelled amino acid on coupling wit

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180603

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractN‐[1‐2H]‐ (5a) and N‐[1‐3H]‐Cyclopropylbenzylamine (5b) were synthesized from cyclopropanecarbonitrile. The α‐proton of cyclopropanecarbonitrile was exchanged in [O‐2H]‐ and [O‐3H]‐methanol using sodium methoxide as the base. [α‐2H]‐ and [α‐3H]‐Cyclopropanecarbonitrile were hydrolyzed in 4N HCl to the α‐labeled cyclopropanecarboxylic acids which were converted to [1‐2H]‐ and [1‐3H]‐cyclopropylamine. HCl by Curtius rearrangements. The labeled cyclopropylamines were benzylated by reaction with benzaldehyde followed by sodium cyanoborohydride reduction. [phenyl‐14C]‐Cyclopropylbenzylamine (2b) was prepared by the reaction of cyclopropylamine with [phenyl‐14C] benzaldeh

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180604

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractA mixture of brominated melatonin derivatives has been synthesized for use as starting material for preparation of ring tritium labelled melatonin by catalytic hydrogenolysis. The high specific activity obtained makes this product useful in radioimmunoassay studies.

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180605

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractSeveral211At‐astatopyrimidines (5‐At‐uracil, 5‐At‐cytosine and their nucleosides and nucleotides including DNA and RNA) have been synthesized in high radiochemical yields by reaction of211At/I2and the corresponding chloromercury compounds. Also some astato‐steroids (6‐At‐cholesterol and 2‐ and 4‐astatoestradiol) have been prepared by this method. The stability in vitro was determined under different conditions in comparison with the analo

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180606

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractPropionic‐3‐14C acid was prepared by methylation of tricarbethoxymethane and subsequent hydrolysis. This method avoids the problems of malonic ester synthesis. A pure monoalkyl derivative was obtai

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180607

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

Abstract3‐Benzylamino‐8, 9‐dimethoxy‐5, 6‐dihydro‐imidazo‐ [5,1‐a] isoquinoline hydrochloride was labelled with14C in two different positions: In one case the14C was built into the position 2 of the imidazole ring, in the other case into the position 3 of the isoquinoline ring. In the first case the mechanism of the halogen‐cyano exchange reaction of 1‐chloromethyl‐5, 6‐dimethoxy‐3, 4‐dihydro‐isoquinoline was inves

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180608

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractSynthesis of 6,7‐dihydro‐10‐trideuteromethyl‐6,8,8‐trimethyl‐8H‐pyrano[3,2‐g] chromone‐2‐carboxylic acid (10) in high isotopic purity is described. The trideuteromethylation was achieved by sodium borodeuteride reduction of the ethoxycarbonyl derivative (5) of 7‐hydroxy‐2,2,4‐trimethylchroman‐8‐carboxylic acid (4). This labelled compound (10) is required for use as mass spectrometric stable isotope internal standard for the study of metabolic fate of 6,7‐dihydro‐6,8,8,10‐tetramethyl‐8H‐pyrano[3,2‐g] chromone‐2‐carboxylic acid (9),

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180609

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

AbstractThe reaction of75Se‐sodium selenite with cysteine, cystine and glutathione was studied. Selenodicysteine and selenodiglutathione were obtained as the incorporation products of inorganic selenium. The incorporation of selenium into these organic compounds is greatly affected by pH. The equilibrium constants of the selenodicysteine and selenodiglutathione formation were calculated. The stability of selenodicysteine in a strong acidic solution, in the hydrogen peroxide solution and in the presence of mercaptoethylamine were investigated. The mechanism of the decomposition of the investigated selenium compounds was suggeste

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180610

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY

摘要:

Abstract3‐[11C]‐Methyl‐D‐glucose was synthetized by methylation via11CH3I of the potassium salt of diacetone‐D‐glucose; hydrolysis of the ketal groups with HCl yields 3‐[11C]‐methyl‐D‐glucose. The radiochemical yield is 35% at a specific activity of 1.9 mCi/μmole. Synthesis time including purification by hplc is about 30 min. Up to 12.0 mCi have been obtained in injectable solution.The tissue distribution of 3‐[11C]‐methyl‐D‐glucose was determined in mice at different times after an i.v. injection. All well‐perfused organs like lung, heart, liver, kidney and brain rapidly accumulate 3‐[11C]‐methyl‐D‐glucose. The accumulation in brain is significant: at 15 min after ap

ISSN:0362-4803    

DOI:10.1002/jlcr.2580180611

出版商:John Wiley&Sons, Ltd.    

年代:1981

数据来源: WILEY