摘要:

AbstractPreparative, separative and analytical methods are described for the following labelled compounds: 4‐amino[5‐14C] formamidouracil (II), 1,3‐dimethyl‐4‐amino[5‐14C]formamidouracil (III), 1,3‐dimethyl[S‐14c]xanthine ([8‐14C]theophylline) (IV), 1,3,7‐trimethyl [8‐14C]xanthine ([8‐14C]caffeine) (V), 4‐amino[2‐14C]uracil (VI),′ 4‐amino‐5‐nitroso[2‐14C]uracil (VII), 4,5‐diamino[2‐14C]uracil (VIII), [2‐14C]xanthine (IX), 3‐methyl[2‐14C]xanthine (X), [2‐14C]theobromine (XI), [2

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120302

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractBenzoyl chloride‐714C is condensed with tris(trimethylsilyl) 1‐lithio‐1,1,2 propane tricarboxylate, which after hydrolysis gives rise to a 66% yield of 2‐methyl‐3‐(benzoyl‐7‐14C) propionic acid. After cyclisation with hydrazine, followed by treatment with bromine in acetic acid, 3‐hydroxy‐4‐methyl‐6‐phenyl pyndazine 6‐14C is secured in a 77% yield. This hydroxypyridazine treated with POCl3gave a 90% yield of 90 % pure 4‐methyl‐6‐phenyl‐3‐chloropyndazine 6‐14C; The latter treated with 2‐morpholino‐1‐aminoethane in presence of sodium iodide has given 3‐morpholinoethylamino 4‐methyl 6‐phenylpyndazine 6‐14C. The overall yield based on barium carb

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120303

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractThe syntheses of [γ‐14C]‐γ‐oxo‐2‐dibenzofuranbutanoic acid (furobufen)7and 2‐dibenzofuranacetic[carboxy‐14C] acid3b, a major metabolite of furobufen, are described. A by‐product, the dialkylated malonate6obtained in the synthesis of7, was isolated

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120304

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractWhen lyophilized samples of bovine pancreatic ribonuclease are exposed to tritium gas, the exchange process can be markedly improved by applying high frequency electric discharges.Labelling has been carried out for 5, 15 or 30 minutes periods. Labile radioactivity, was then removed by means of molecular sieving and repeated lyophilizations, the tritiated protein being submitted to further purification by ion‐exchange chromatography.The specific radioactivity of such purified samples is in the Curie/mmole range, and the biological activity of the enzyme remains well preserved. The distribution of tritium atoms among component aminoacids has been determined, after acid hydrolysis of the labelled protei

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120305

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractSodium formate‐13C, prepared by hydrolysis of isopropyl formate, was allowed to react with N‐methylaniline hydrochloride to prepare the formylating agent N‐methylformanilide‐1‐13C. Formylation of benzo(a)pyrene with N‐methylformanilide‐1‐13C gave the 6‐13CHO derivative which was reduced to 6‐13CH3and 6‐13CH2OH benzo(a)pyrenes. 6‐13CH2C1 benzo(a)pyrene was prepared from t

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120306

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractThe synthesis of two peptides, L‐cystinyl‐bis‐L‐valine and bis‐6‐(L‐2‐aminoadipyl)‐L‐cystinyl‐bis‐L‐valine, labeled with L‐valine‐14C(U) or L

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120307

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractL'échange indirect de l'hydrogéne aldéydique par du deutérium dans un aldéhyde éthylénique conjugué peut se faire par l'intermédiaire du dithianne ‐1,3 correspondant, aprés traitement par le butyllithium ou mieux le méthyl‐lithium suivi d'hydrolyse par D2O et régénération de 1

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120308

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

Abstract5‐Methoxy‐2‐methyl‐1‐(3,4‐methylenedioxybenzoyl)indole‐3‐acetic acid (ID‐955)(I), a new anti‐inflammatory agent, was labelled with carbon‐14 at C‐2 position of indole nucleus for the use of metabolic studies. The procedure used is shown in Fig. 1 and 2. Levulinic‐4‐14C acid was synthesized in 57% yield by condensation of ethyl acetoacetate‐3‐14C with ethyl bromoacetate and subsequent decarboxylation with hydrochloric acid. Reaction of III with N1‐(3,4‐methylenedioxybenzoyl)‐4‐methoxyphenylhydrazine (II) gave ID‐955‐2‐14C (I) in 58% yield. A total of 10.6 mCi of pure ID‐955‐2‐14c (I) was obtained, representin

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120309

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

AbstractMercury(II) oxide oxidation of naltrexone (1a) and naloxone (1b) gave 15,16‐didehydronaltrexone (4a) and 15,16 didehydronaloxone (4b). Subsequent reduction of4awith tritium gas afforded naltrexone‐15,16‐3H2having a‐specific activity of 15.3 Ci/mmole. Subsequent equilibration of4bwith carrier free tritium oxide followed by sodium cyanoborohydride reduction yielded naloxone‐15‐3H having a specific activity of

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120310

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY

摘要:

Abstract1‐Ethyl‐6,7‐methylenedioxy‐4(1H)‐oxocinnoline‐3‐carboxylic acid (cinoxacin) (1), an effective antimicrobial agent has been labelled with carbon‐14. The carbon‐14 was incorporated into the C‐4 position of the molecule to give XIV in 10.0% overall radiochemical yield based on barium carbonate‐14C. The13C‐,15N‐, and d‐labelled compounds (XV, XVII, and XVIII) have also been synthesized for absorp

ISSN:0362-4803    

DOI:10.1002/jlcr.2580120311

出版商:John Wiley&Sons, Ltd.    

年代:1976

数据来源: WILEY