摘要:

Circulating immunoreactive α-interferon in elderly individuals was 0.139 ± 0.042 ng/ml in males and 0.Ill ± 0.033 ng/ml in females at ages 70–79, and 0.120 ± 0.045 ng/ml in males and 0.105 ± 0.039 ng/ml in females at ages 80–89. These values were significantly lower than those in young adults (p < 0.01), but higher compared with the values found in disease states including rheumatoid arthritis (p < 0.0025). There was no correlation between circulating α-interferon and bone mass indices, such as bone mineral content or quantitative computed tomography values, in these elderly individuals. Circulating α-interferon was, however, significantly increased in senile osteoporotic patients after 2 months of treatment with 1 α-hydroxyvitamin D3 or calcitonin, whereas it was unaltered in patients receiving ipriflavone or in nonosteoporotic individuals without medication. These findings indicate that circulating α-interferon, which is highest in young adults, declines with aging. It appears that circulating α-interferon is maintained at a certain steady-state level in healthy elderly individuals. Although there was no apparent relationship between bone mass indices and circulating α-interferon, it is possible that bone and cellular metabolism related to vitamin D3 may be contributing factors for the maintenance of circulatin

ISSN:0304-324X    

DOI:10.1159/000213041

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

The effect of large-dose short-term administration of Max-Epa fish oil on serum lipoproteins in elderly people was studied. 17 elderly (aged 61–96 years) hospital patients were given an isocaloric diet which contained 70–80 ml (14–16 g of eicosapentaenoate) of Max-Epa fish oil for 3 weeks. The concentration of plasma total cholesterol and LDL cholesterol decreased significantly during the diet with fish oil. The levels of plasma VLDL cholesterol, HDL cholesterol and triglycerides decreased slightly (p < 0.05). The concentration of apoprotein A decreased significantly (p < 0.001) during the fish oil diet but the plasma level of apoprotein B did not change significantly. The ratio of apoprotein B to LDL cholesterol increased significantly (p < 0.01) during the period with Max-Epa fish oil. The results show that marked changes in the lipoproteins of the elderly people occur when diet contains large doses of fis

ISSN:0304-324X    

DOI:10.1159/000213042

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

Diffusing capacity (DLCO) was measured in 260 healthy subjects aged 60–86 years who were leading an active life in the community. DLCO correlated with body surface area and spirometric indices, and declined with age. It was lower in women, in smokers and in those with chronic bronchitis. Multiple regression equations based on age and body surface area were derived for elderly Chinese men and women. Compared with predicted values based on studies of Caucasians of all ages, those for elderly Chinese men were higher, while those for elderly women were similar. Predicted values for an elderly Chinese population should be derived from equations established from this survey rather than those extrapolated from Caucasians of all ages. DLCO/VA correlated with weight and body surface area but not with height, and declined with age. There was no difference between men and women, and between those with or without symptoms of chronic bronchitis. Predicted values from this study of elderly Chinese were comparable to those derived from Caucasians of all ages. Differences in DLCO values for elderly Chinese compared to Caucasians may be explained by differences in lung volumes rather than ethnic variations in the diffusing characteristics of the alveolar capillary membrane, and by the small numbers of elderly subjects in some of the studies of Caucasian subject

ISSN:0304-324X    

DOI:10.1159/000213043

出版商:S. Karger AG    

年代:1989

数据来源: Karger

摘要:

This study examines some aspects of spatial orientation mechanisms in idiopathic elderly fallers. Tests of visual perception of verticality and horizontality showed no significant difference between 6 fallers and 6 controls, although 50% of fallers indicated difficulties in the recognition of postural tilt. Results of responses to standing balance indicated that fallers leant more heavily on a supporting frame and were more spatially deflected when standing on one leg than were controls. The results suggest that fallers may rely on visual cues to recognise and correct postural deviations, thus implying that their proprioceptive feedback is impaired.

ISSN:0304-324X    

DOI:10.1159/000213044

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000213045

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000213046

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000213047

出版商:S. Karger AG    

年代:1989

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000213030

出版商:S. Karger AG    

年代:1989

数据来源: Karger