摘要:

Electron microscopic examination of the retinal vascular system in two species of rodents (spiny mice and rats), with subsequent morphometπcal evaluation of capillary basement membrane (BM) thickness and diameter, revealed an age-correlated basement membrane thickening in both species and an age-correlated increase of capillary diameter and a positive correlation between these two parameters in spiny mice. Further more, a positive correlation was found between body weight and BM width in rats. A discussion of the standard deviation of thevalues obtained, as well of factors other than age influencing BM width, are presented

ISSN:0304-324X    

DOI:10.1159/000211955

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

A brief experiment is described in which it was found that a smaller proportion of old than young people were systematic in the way they searched for a hidden target.The unsystematic strategy employed by relatively more old than young people is arguably suboptimal. Similar instances of suboptimality in older peoples’ prediction behaviour may be interpreted in terms of an age difference in the ability of Ss to detach their attention from ‘hunches’. It is clear that research on age-related strategies of performance is a viable and possibly important area for investig

ISSN:0304-324X    

DOI:10.1159/000211956

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Studies were performed in order to find out whether the duration of immunologic memory is impaired when priming is done at a time in which the primary anti-body-forming capacity begins to decrease, i.e., at an age of about 12 months. Female NMRI mice of either 3 (optimally responding animals) or 12 months were primarily immunized with a ‘saturated’ dose of 4 × 108 sheep erythrocytes. Both groups of animals were boosted either 1 4, or 8 months after primary antigenic stimulation. The immune responses were measured by the direct and indirect antibody plaque techniques and by serological procedures. There was no significant difference regarding the secondary immune potential of both mouse groups on all examinat

ISSN:0304-324X    

DOI:10.1159/000211957

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The aim of this study was to assess the influence of age on the following three non-cognitive factors of personality: emotional stability, dominance and extraversion. In order to have a better estimation of that influence, changes in these factors have been compared with changes already well known in cognitive ability. The following four tests were used: C, E and F scales of the Cattell’s 16-PF inventory and the Kohs’ block design test. The authors have analysed the results obtained according to these four tests with 140 normal male aged subjects. These subjects have been divided into five age groups (60–64, 65–69, 70–74, 75–79, 80–84) which were matched for socio-cultural level. The various comparisons made have shown differences among the four factors studied. As far as the emotional stability scale is concerned, one can note: (1) that the scores obtained by aged subjects do not differ from those observed in young subjects ranging in age from 18 to 40; (2) that these scores do not alter significantly from 60 to 84 years. The scores on the extraversion and dominance scales also remain perfectly stable between 60 and 84 years. Aged subjects, however, appear simultaneously less extraverted and less dominant than young adults. As would be expected, performances achieved by aged subjects with the Kohs’ block design test are far inferior to those achieved by young subjects. For subjects of 60–84 years, the aforementioned performances decline in a statistically significant linear function. Generally speaking, non-cognitive factors seem to alter much less with age than

ISSN:0304-324X    

DOI:10.1159/000211958

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

In experiments on adult and old rats, rabbits and cats, the age peculiarities in acetylcholine (ACh) metabolism and realization of cholinergic influences upon the effectors were investigated. In aging, biosynthesis and hydrolysis of ACh decrease (choline-acetyltransferase and cholinesterase activities are decreased). In old age, the nervous cholinergic influences upon organs and tissues weaken.Alongside with this, the sensitivity of various organs andsystems to cholinomimetic and cholinolytic substances increases.

ISSN:0304-324X    

DOI:10.1159/000211959

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

The techniques behind the investigation of freeradical, somatic mutation, and DNA-protein deterioration theories are no longer adequate to further our knowledge significantly on the role of DNA-protein complexes in aging dysfunction. Clearly, only the preliminaries were accomplished by studies based on the hypotheses of DNA-protein interactions for aging. As we see it, we urgently need to address ourselves to one simple question at a time, specifically to age changes in the DNA-protein complex, a potential site of primary changes leading to aging dysfunction.

ISSN:0304-324X    

DOI:10.1159/000211960

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000211961

出版商:S. Karger AG    

年代:1973

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000211962

出版商:S. Karger AG    

年代:1973

数据来源: Karger