摘要:

The rate of phagocytosis of 59Fe-labeled erythrocytes of various ages was measured in the rabbit. Liver, spleen and the remaining parts of the reticulohistiocytic system (RHS) were compared with each other. The phagocytic activity in the liver increased from 66% in 4-day-old to nearly 90% in 70-day-old erythrocytes, whereas the radioactivity decreased in the other parts of the RHS from 33 to 3%. In the spleen, the radioactivity increased from 1.7 to 7.6%. On the 8th day, the radioactivity in the liver temporarily amounted to 92%, reducing that of the other organs. Comparison of the phagocytic activity per gram showed a ratio of liver to spleen of 1:2 after 4 days which changed to 1:5 after 70 days.

ISSN:0304-324X    

DOI:10.1159/000212527

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Calcium absorption, excretion and balance were determined in young, mature and aged mice ingesting a lysine-deficient diet. Age had no affect on these parameters. However, lysine deficiency, in all age-groups, resulted in a marked increase in urinary calcium excretion, unaccompanied by any significant changes in bone composition.

ISSN:0304-324X    

DOI:10.1159/000212528

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Alloxan-diabetic collagen from the bone, skin and tendon showed an increased resistance to digestibility by bacterial collagenase, suggesting greater stability of the molecules. These results corroborate our earlier findings that alloxan diabetes accelerates the ageing of collagen in mice, the degree of such an effect being tissue and sex dependent.

ISSN:0304-324X    

DOI:10.1159/000212529

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

The development of age-associated proteinuria and renal disease was studied in groups of male Wistar rats fed 12.5, 25, 50 and 75 kcal of food/day, respectively, and in calorie-restricted (40 kcal/day) rats receiving diets rich in fat, protein or carbohydrate. Proteinuria developed faster, kidneys were larger and the incidence of glomerular lesions and proteinaceous casts was greater in rats eating high calorie diets of 50 kcal/day or more. High protein diets, even when calorie-restricted, increased protein excretion and the incidence of glomerular lesions. In old rats acute food restriction (25 kcal/day) decreased protein excretion by 40 % in 1 week, with no further reduction in the 2 week. Life duration was greatest in rats fed 50 kcal/day.

ISSN:0304-324X    

DOI:10.1159/000212530

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Fasting serum lipid and lipoprotein concentrations and related characteristics were measured in 70 female and 33 male nonagenarians and in a control group of 61 women and 48 men aged 70 years when sampled. Both groups were randomly selected from the Giessen area. The mean age ( ± SD) of the nonagenarians was 91.7 ± 2.5 years. Mean ( ± SD) serum total cholesterol (TC), total serum triglyceride (TG), very low density triglyceride, low-density cholesterol (LDL-C), and high-density cholesterol (HDL-C) were higher in nonagenarian women than in nonagenarian men: 219.0 ± 46.4 and 203.5 ± 42.1 mg/dl, 1.64 ± 1.15 and 1.06 ± 0.38 mmol/l (p ≤ 0.001), 1.04 ± 1.03 and 0.62 ± 0.34 mmol/l (p ≤ 0.01), 137.8 ± 37.5 and 133.8 ± 38.5 mg/dl, 54.4 ± 15.5 and 51.8 ± 14.4 mg/dl, respectively. The 90th percentile levels for TG, very low density triglyceride, TC, LDL-C, and HDL-C in the nonagenarians were 2.34 and 1.58 mmol/l, 267, 193 and 76 mg/dl, respectively, the 10th percentile levels being 0.72 and 0.32 mmol/l, 153, 87, and 34 mg/dl. In the control group the 90th percentile level for HDL-C was found to be more favorable, being 79 mg/dl. In both females and males TC was closely correlated with LDL-C, r = 0.84, 0.93, p < 0.001, whereas TG and HDL-C were inversely correlated, r = ––0.39, ––0.40, p < 0.001, < 0.05. Primary hyper-α-lipoproteinemia (HAL), defined as HDL-C level ≥ 70 mg/dl, was found in 17 nonagenarians (13 women and 4 men) and in 23 70-year-old subjects (20 women and 3 men). The difference in favor of the younger group was not significant. 4 nonagenarians and 3 70-year-old subjects exhibiting primary HAL, selected as probands for family studies, showed a familial aggregation of HAL, thus identifying them as having familial HAL. Primary hypo-β-lipoproteinemia (HBL) was tentatively identified in only 1 female nonagenarian. The nonagenarians with and without HAL did not differ with regard to their relative distribution to one of three different vitality groups and not even with regard to their relative weight and electro-cardiographic findings. A definite or trace sinking pre-β-lipoprotein band was found in 42 and 17 nonagenarians, respectively, without relation to sex, relative body weight, lipid and lipo-protein concentrations and prevalence of atherosclerotic vascular disease/cardiac insufficiency. Hypo-α-lipoproteinemia (defined as HDL-C level ≤ 45 mg/dl in women and ≤ 35mg/dl in men) was the most frequently encountered lipid abnormality, occurring in 3 very old men and in 24 very old women, followed by the presence of type IV hyperlipoproteinemia (defined as TG level ≥ 2.26 mmol/dl) in 10 female nonagenarians. The LDL-C concentrations of the nonagenarians did not exceed 207 mg/dl. Longevity analyses, based on personal communications and not on certificates of death, revealed no differences in the life expectancy of ancestors (mothers/fathers/parents) in the two study groups and in relation to primary HAL/HBL of their nonagenarian/septuagenarian offspring. When the siblings of the nonagenarians were included in the calculations, the analysis showed that longevity was quite customary in these nonagenarian families. The reported data do not provide evidence for an association of prim

ISSN:0304-324X    

DOI:10.1159/000212531

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

This study of bronchopneumonia as a cause of death in the elderly has been carried out in two parts. The first part deals with postmortem analysis and the second with death certificates based on clinical judgement. Both parts of the study confirmed bronchopneumonia to be one of the most common causes of death among the elderly and its incidence rose with advancing age. The causes, diagnostic difficulties, and the results of the two parts of the study have been compared and discussed.

ISSN:0304-324X    

DOI:10.1159/000212532

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

The change in size of the larynx with respect to age was investigated. In general the female larynx grows smaller with increasing age, but there is no similar age effect in men. The incidence and extent of squamous metaplasia was also studied. Two parts of the larynx showed age-related changes: in men, metaplasia of the vestibular folds became more common with age up to the age of 60, but then became less common again. In men also, the incidence and extent of squamous metaplasia increased with ageing. These age-related changes may relate to the development of laryngeal carcinoma, an event which must be preceded by squamous metaplasia.

ISSN:0304-324X    

DOI:10.1159/000212533

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000212534

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000212535

出版商:S. Karger AG    

年代:1982

数据来源: Karger