摘要:

The age-dependent changes in reducible collagen cross-links, Schiff bases and their precursors were followed for human bone and articular cartilage throughout the whole life span from 3 to 89 years of age. With aging, the reduced Schiff bases dihydro-ylysinonorleucine remarkably decreased, whereas hexitollysine peaks increased significantly in both collagens. Dihydroxynorleucine, the precursor of the cross-link, was found to increase slightly with age. But the changes in hydroxylysinonorleucine and lysinonorleucine were comparatively small. These changes were discussed in relation to the increased insolubility observed in both collagens at higher age.

ISSN:0304-324X    

DOI:10.1159/000212148

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Cell surface of chick fibroblasts were labelled by a short treatment with 125I in presence of lactoperoxidase. A glycoprotein (220,000 molec.wt) was iodinated and was present in a more exposed position or in greater amounts at the surface of old phase III cells compared to young phase II cells. The findings extend our previous observations on cell surface modifications in in vitro senescing fibroblasts.

ISSN:0304-324X    

DOI:10.1159/000212149

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000212150

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000212151

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000212152

出版商:S. Karger AG    

年代:1976

数据来源: Karger