摘要:

We have previously shown that lymphocytes from Alzheimer’s disease (AD) patients are hypersensitive to ionising radiation, as revealed by their higher levels of dicentrics than those from age-matched, normal individuals. We have now examined the sensitivity of these cells to N-methyl-N-nitrosourea or methyl methanesulphonate, using a variety of assays, namely unscheduled DNA synthesis, viability, sister chromatid exchange and, via high performance liquid chromatography, level of methylation and repair of the adducts, 7-methylguanine, 06-methylguanine and 3-methyladenine. We have found that AD lymphocytes and age-matched normal lymphocytes respond similarly to methylation damage, as assessed by all these technique

ISSN:0304-324X    

DOI:10.1159/000213539

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

The study of the genetic determinism of longevity in Drosophila melanogaster has made use of the technique of late-age reproduction. At low larval density, that indirect selection showed no effect. At high larval density, however, increased mean life-span in lines reproduced at late age was observed. When these last data are examined as a function of the number of days after the beginning of the experiment, instead of as a function of generations, the difference in life-span between early and late lines at high larval density disappears. The erratic evolutions of mean longevities in all the experiments here described may be attributed to unexplained variations in life-span previously observed in a 4-year experiment. Considering the time lag between the measurement of a given generation in early and late lines, the experiments of reproduction at late age cannot demonstrate the genetic determinism of longevity.

ISSN:0304-324X    

DOI:10.1159/000213540

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

To determine whether the detection of parietotemporal functional abnormalities as demonstrated by single photon emission computed tomography (SPECT) can be employed as a diagnostic marker for Alzheimer’s disease (AD), we studied 219 patients with neurologic disorders including 56 with AD and 25 healthy controls. The diagnostic sensitivity (parietotemporal hypoperfusion present in AD patients) was 82%, and the specificity (parietotemporal hypoperfusion absent in non-AD patients and controls) was 89%. These results suggest that SPECT imaging provides an accurate and sensitive diagnostic test for A

ISSN:0304-324X    

DOI:10.1159/000213541

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Spirometric parameters including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and various parietal parameters (superior and inferior rib cage and abdominal maximal expansion amplitudes) were measured in 65 ambulatory subjects aged over 75 years. The population was divided into three age groups: group 1: 75–79; group 2; 80–84, group 3: 85 and older. A marked decrease in clinical and spirometric results was observed between groups 1 and 2, and 1 and 3, but there was no difference between groups 2 and 3. Such findings might be attributed to a survival effect. There was a high correlation between the parietal parameters and FVC and FEV1. In clinical practice, this simple parietal assessment may be of value in the identification of elderly subjects at risk of acute respiratory distr

ISSN:0304-324X    

DOI:10.1159/000213542

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

We performed this study in order to verify the existence of a correlation between early platelet count reduction and initial neurological impairment, infarct extension and mortality or clinical outcome in an established ischemic cerebral infarction. The results demonstrate that the platelet consumption and/or accumulation in the infarct area, expressed by circulating platelet decrease, is related to the severity of neurological involvement, infarct size and poor clinical outcome.

ISSN:0304-324X    

DOI:10.1159/000213543

出版商:S. Karger AG    

年代:1993

数据来源: Karger

摘要:

Event-related P300 potentials are closely reflecting cognitive functions such as stimulus evaluation time (P300 latency) and task relevance (P300 amplitude). Hence, both their potential clinical application for detecting slight cognitive disturbances and an increasing interest in the aging of cognitive human brain functions resulted in a growing number of studies on age-related P300 changes. Although there are converging lines of evidence that aging results in prolongations of P300 latencies, reductions of P300 amplitudes and a more equipotential P300 scalp distribution, the amount of these changes and the best fit for the P300-age interactions, respectively, remain still controversial. In general, these P300 alterations obviously reflect only minor cognitive changes during normal aging. For their clinical application, however, it is necessary to obtain an age-matched normative database. Furthermore, the increased P300 variability in the elderly has to be reduced – as far as possible – by appropriate simple P300 paradigms which should be preferentially applied in longitudinal analyses to differentiate normal from pathological aging of cognitive functions. Finally, additional cross-correlational analyses between the P300 and morphological as well as neurobiochemical data are needed. By these means, our knowledge about age-related changes of cognitive brain functions should be considerably enlar

ISSN:0304-324X    

DOI:10.1159/000213544

出版商:S. Karger AG    

年代:1993

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000213545

出版商:S. Karger AG    

年代:1993

数据来源: Karger