摘要:

The cell-free protein synthetic activity of the postmitochondrial supernatant isolated from whole brain of 6- to 32-month-old male Fischer F344 rats was compared. Protein synthesis decreased 56% from 6 to 32 months of age. The decrease in cell-free protein synthesis was not due to an age-related increase in RNase activity. Although monomeric ribosomes (ribosomes stripped of mRNA) isolated from the brains of older rats were less active in polyuridylic acid directed polyphenylalanine synthesis, the fidelity of polyuridylic acid translation by monomeric ribosomes did not decrease with increasing age.

ISSN:0304-324X    

DOI:10.1159/000212405

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

A reduction in nuclear template activity occurred in He 125 cell cultures only after the expression of a reduction in growth ability. This suggests that these alterations in template activity are terminal events occurring late in the culture life span. Both the rate of loss of template activity and its qualitative aspects were influenced by the growth state of the cultures compared. Therefore, these factors should be taken into account in the analyses of the relationship between in vitro ‘ageing’ and nuclear template activ

ISSN:0304-324X    

DOI:10.1159/000212406

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The fundamental cause(s) of senescent deterioration remain(s) to be established. Numerous attempts have been made to relate changes found at the cellular level with altered or failing functional changes occurring at the molecular level. However, the apparently contradictory published data often make it very difficult if not impossible, to decide whether any conclusive evidence has been provided. In this article, we have reviewed the attempts to relate in vitro ‘ageing’ with alterations in nuclear template function and have made brief mention of the few complementary in vivo experiments. Results from studies of chromatin function during in vitro ‘ageing’ in general favour the suggestion that the reduction in template activity with increasing ‘age’ may result from the loss of cellular division potential, so being an effect rather than a cause of in vitro ‘ageing’. However, nuclear control of ‘ageing’ via specific transcript ional mechanisms cannot be excluded by these data. It is possible that minor or discrete species of RNA are involved, but their investigation and detection await the development of new or more sensitive methodologies. Therefore, published data are consistent with theories of genetically programmed cellular senescence and terminal differentiation, but they do not allow us to decide firmly in favour

ISSN:0304-324X    

DOI:10.1159/000212407

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

This paper presents a survey of manifestations of Paget’s disease, osteitis deformans of the head and neck. The pathology and pathogenesis of the disease are considered and the clinical manifestations examined in relation to the area of the skull involvement, outlining ocular, auditory, vestibular, dental and general manifestation

ISSN:0304-324X    

DOI:10.1159/000212408

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

A quarter of the thyroid glands obtained at post-mortem examination from a group of elderly inpatients were nodular. There was a significant preponderance of women with goitre, but no relationship to age. The incidence of hyperthyroidism was increased in patients with nodular glands. There was no correlation between the weight of the thyroid gland, the age of the patient and the free-thyroxine index. Histological examination of macroscopic ally normal glands showed tiny follicles, microscopic colloid nodules and fibrosis. Nodular glands had the features of long-standing colloid nodular goitre. Focal lymphocytic thyroiditis was observed in a fifth of the glands. Microscopic evidence of altered function was common but could not always be correlated with the results of the thyroid function studies.

ISSN:0304-324X    

DOI:10.1159/000212409

出版商:S. Karger AG    

年代:1980

数据来源: Karger

摘要:

The elastase content of the serum of stroke patients is appreciably higher immediately after the cerebral incident and, in the case of those destined to survive, falls subsequently back to the normal level for their age group. The degree of elevation of the elastase content, the period which elapses before it is attained and the rate at which the level returns to normal are all age related. Those patients who die within 1 week of their initial stroke suffer a dramatic rise in serum elastase content immediately prior to death.

ISSN:0304-324X    

DOI:10.1159/000212410

出版商:S. Karger AG    

年代:1980

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000212411

出版商:S. Karger AG    

年代:1980

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000212412

出版商:S. Karger AG    

年代:1980

数据来源: Karger