1. |
The Effect of Ginseng on Lifespan and Stress Responses in Mice |
|
Gerontology,
Volume 25,
Issue 3,
1979,
Page 125-131
A.H. Bittles,
S.J. Fulder,
E.C. Grant,
M.R. Nicholls,
Preview
|
PDF (1825KB)
|
|
摘要:
It has been suggested that ginseng can increase long-term resistance to stress and disease and therefore affect the lifespan. We set out to investigate this idea by testing whether the continuous administration of ginseng could affect the lifespan of mice and/or their behavioural response to stress. 270 mice of strain LACa were divided into three groups: one group which was given ginseng from 8 weeks of age, a second group which was given ginseng from 52 weeks of age and an untreated control group. The mice were generally healthy. Their weights remained stable throughout their lifespan and were not altered by ginseng. Ginseng administration did not significantly alter the lifespan. However, ginseng did cause an exaggeration of the behavioural responses to mild stress. This effect was noticeable soon after ginseng administration and subsequently was maintained.
ISSN:0304-324X
DOI:10.1159/000212330
出版商:S. Karger AG
年代:1979
数据来源: Karger
|
2. |
Aldolase Activity and Cross-Reacting Material in Lymphocytes of Aged Individuals |
|
Gerontology,
Volume 25,
Issue 3,
1979,
Page 132-135
Elisabeth Steinhagen-Thiessen,
Helmuth Hilz,
Preview
|
PDF (1116KB)
|
|
摘要:
Aldolase activity was determined in human lymphocytes from 21 donors aged 18–84 years. The lymphocyte extracts contained exclusively aldolase A isozyme. No significant difference in enzyme activity between adult (18–41 years) and old (56–84 years) age groups was observed. There was also no significant decrease with age of ‘cross-reacting material’ as determined with monospecific anti-aldolase A a
ISSN:0304-324X
DOI:10.1159/000212331
出版商:S. Karger AG
年代:1979
数据来源: Karger
|
3. |
An Evaluation of Some Theories of the Mechanism of Aging |
|
Gerontology,
Volume 25,
Issue 3,
1979,
Page 136-144
John Morrow,
Charles Garner,
Preview
|
PDF (1540KB)
|
|
摘要:
Two theories of aging are considered in this review. Although there exists substantial experimental evidence in support of the somatic mutation and error catastrophe hypotheses, several experiments have been published which are extremely difficult to reconcile with these models, at least in their simplest forms. These include the observation that biochemical and morphological degenerative changes observed in fibroblasts aged in vitro do not resemble alterations observed in cells obtained from aged donors, and the fact that tissues transplanted serially through different hosts do not decline in vigor in the manner predicted by the somatic mutation theory. Although biochemical and mutational alterations appear to accumulate in fibroblasts aged in vitro (in support of the error catastrophe model), there are substantial problems with the interpretation of such experiments, and some observations (such as the lack of increase in translational error in hemoglobin synthesis as a function of age) seem to argue directly against the error catastrophe theory. Some alternative theoretical and experimental possibilities are discussed, including the concept of programmed aging as the cause of senescence.
ISSN:0304-324X
DOI:10.1159/000212332
出版商:S. Karger AG
年代:1979
数据来源: Karger
|
4. |
Effect of Age on the Retraction of Skin |
|
Gerontology,
Volume 25,
Issue 3,
1979,
Page 145-150
P.M. Stell,
Preview
|
PDF (1606KB)
|
|
摘要:
The retraction of skin flaps was measured. A constant decrease in retraction of 0.33% per year was found throughout life between the ages of 20 and 70.
ISSN:0304-324X
DOI:10.1159/000212333
出版商:S. Karger AG
年代:1979
数据来源: Karger
|
5. |
Treatment of Paget’s Disease of Bone |
|
Gerontology,
Volume 25,
Issue 3,
1979,
Page 151-158
N.K. Chakravorty,
Preview
|
PDF (2538KB)
|
|
摘要:
A brief review is given of the use of fluoride, mithramycin, glucagon, actinomycin D, calcitonins and diphosphonates for treatment of Paget’s disease of bone. The decision regarding treatment, effectiveness of the drugs, the incidence of side effects and assessment of clinical, biochemical, histological, radiological and thermographic responses are discusse
ISSN:0304-324X
DOI:10.1159/000212334
出版商:S. Karger AG
年代:1979
数据来源: Karger
|
6. |
International Conference on Molecular and Cellular Models of Aging |
|
Gerontology,
Volume 25,
Issue 3,
1979,
Page 159-175
Preview
|
PDF (3291KB)
|
|
ISSN:0304-324X
DOI:10.1159/000212335
出版商:S. Karger AG
年代:1979
数据来源: Karger
|
7. |
Recent Articles in Experimental Ageing Research |
|
Gerontology,
Volume 25,
Issue 3,
1979,
Page 176-180
Preview
|
PDF (1752KB)
|
|
ISSN:0304-324X
DOI:10.1159/000212336
出版商:S. Karger AG
年代:1979
数据来源: Karger
|
8. |
Book Reviews |
|
Gerontology,
Volume 25,
Issue 3,
1979,
Page 181-183
Preview
|
PDF (954KB)
|
|
ISSN:0304-324X
DOI:10.1159/000212337
出版商:S. Karger AG
年代:1979
数据来源: Karger
|
9. |
Varia |
|
Gerontology,
Volume 25,
Issue 3,
1979,
Page 184-184
Preview
|
PDF (73KB)
|
|
ISSN:0304-324X
DOI:10.1159/000212338
出版商:S. Karger AG
年代:1979
数据来源: Karger
|