摘要:

The rate of growth of the DNA chain length was found to decrease in rat spleen with aging. This can be substantiated by the slowing down of transformation of old spleen 3H-labeled DNA with low molecular weight to that with high molecular weight as labeling time increases. At the same time, the intensity of the DNA total synthesis is higher in old spleens than in adult ones. This may result from an increase of mitotic activity in rodent spleen with aging. In its turn, the increased mitotic activity may represent an adaptive reaction responsible for maintaining the number of immunocompetent cells which tend to decrease with aging. The slowing down of the newly formed DNA chain growth may lead to the decreased rate of stabilization of the secondary structure of replicating DNA in old spleen.

ISSN:0304-324X    

DOI:10.1159/000212536

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Although the parenteral injection of dextran sulfate 500 (DS 500; 50 mg/kg body weight) into 22-month-old NMRI mice resulted in a complete loss of resistance when administered 1 day before the sublethal (4.5 × 103) infection with Listeria monocytogenes, the consequences in aged animals were less dramatic than in young adult (2- to 3-month-old) controls. This was documented by prolonged survival times as well as reduced numbers of Listeriae in spleen. This indicates that aged mice possess an increased paghocytic capacity, as compared to young adult animals. In aged mice the DS 500-induced loss of resistance could be completely abolished by pretreatment with 3 × 109 heat-killed Bordetellapertussis organisms 4 days before the DS 500 injection, i.e., 5 days before listeric infection. This indicates that aged NMRI mice possess remarkable reserves in phagocytic activit

ISSN:0304-324X    

DOI:10.1159/000212537

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

From weaning to death, 28 male Wistar rats were maintained on an ad libitum (AL) diet, and 24 counterparts were provided the diet every-other-day (EOD). The mean life span of the EOD group represented an 83% increase over that of the AL group. Furthermore, a Gompertzian analysis of mortality rates suggested that the rate of aging was retarded in the EOD group. While body weight and growth rate were reduced in the EOD group, their growth duration was 75% longer compared to the AL group. Significant positive relationships emerged between life span and growth rate parameters in the AL group; however, no significant relationships were found between life span and body weight parameters in the EOD group. Therefore, in support of the hypothesis that dietary restriction effects prolongevity through retarded development, evidence was produced only in the between-group comparisons of AL- and EOD-fed animals.

ISSN:0304-324X    

DOI:10.1159/000212538

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

Linear increase in the ratio of superoxide dismutase to specific metabolic rate as a function of maximum lifespan potential has been proposed as evidence that longevity may be controlled in part by the activity of this enzyme. A role for superoxide dismutase in aging is not supported by these findings since any property which is constant as a function of lifespan will give an excellent linear correlation if plotted as its ratio to specific metabolic rate against lifespan.

ISSN:0304-324X    

DOI:10.1159/000212539

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

The nutrient intakes of 19 chronic geriatric psychiatric patients were determined by recording all food items consumed over a 3-day period and evaluated using the Canadian Dietary Standard. Mean intakes exceeded the recommendations of the Canadian Dietary Standard for calories and all nutrients except calcium, vitamin D, free folate and zinc. Wide individual variations in nutrient intakes were observed. Supplementation with vitamins and minerals did not alleviate all the observed nutrient deficiencies.

ISSN:0304-324X    

DOI:10.1159/000212540

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

An abbreviated mental status questionnaire (MSQ) has been used in 400 patients to assess its prognostic value. Statistical differences were found between some groups of patients with different therapeutic outcomes, but individual scores showed considerable overlap between groups. The MSQ is not a reliable prognostic guide for particular individuals, but it is still of value as a diagnostic aid and in certain other situations.

ISSN:0304-324X    

DOI:10.1159/000212541

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

This paper describes the results in a series of 38 patients who had received injections of colloidal yttrium-90 silicate into rheumatoid joints, mostly knees. 73 joints were injected and followed up for a period of 1–3 years. The results are superior to those of a similar series treated by surgical synovectomy reported by Paradies in 197

ISSN:0304-324X    

DOI:10.1159/000212542

出版商:S. Karger AG    

年代:1982

数据来源: Karger

摘要:

36 patients aged 65 and over who were admitted to hospital after suffering a fall were examined soon after admission and followed for 4 months. 10 patients developed a severe tendency to clutch and grab and were unable to walk unsupported; 9 of these died or were still in hospital 4 months later. 16 patients showed similar signs but were able to walk independently; 5 of these died or were still in hospital after 4 months. 10 patients had no features of the post-fall syndrome; only 1 of these died within 4 months, and one of the survivors remained in hospital. The syndrome may represent the end result of a positive feed-back relationship between disturbed balance and falls.

ISSN:0304-324X    

DOI:10.1159/000212543

出版商:S. Karger AG    

年代:1982

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000212544

出版商:S. Karger AG    

年代:1982

数据来源: Karger