摘要:

Adult Drosophila melanogaster fruit flies ranging in age from 2 to 7.5 weeks with a median colony survival time of 6.4 weeks at 25°C showed no increase in DNA crosslinking with age. The purified denatured DNA used for crosslink determinations varied in molecular weight from 2.02 to 3.84 × 105 daltons and was crosslinked to the extent of 6.2–8.8% with no age-related tr

ISSN:0304-324X    

DOI:10.1159/000212034

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

The ultrastructure of perfused livers and of mitochondrial fractions from 6-month-old and 30-month-old C57/BL mice were studied. In old mice the liver cell mitochondria were enlarged and rounded with a light ‘foamy’, vacuolated matrix, short cristae and a loss of dense granules. Quantitative studies showed a 60% increase in the mean size and an increased proportion of larger mitochondria in intact 30-month-old perfused livers. Endothelial and Kupffer cell mitochondria were smaller than those of the parenchymal cells. Mitochondria in pellets prepared from 6- and 30-month-old livers were rounded and condensed, although there were a few larger and ‘foamy’ mitochondria in the preparations from old mice. Up to 47% of large mitochondria in the old livers were lost during cell fracti

ISSN:0304-324X    

DOI:10.1159/000212035

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

There was no significant difference between the levels of cytochrome oxidase and malate dehydrogenase in whole liver homogenates or in mitochondria isolated from the livers of 6-month-old and 30-month-old C57/BL mice. Little change with age was found in the cytochemical localisation of either enzyme. There were no significant changes in endogenous, state III or state IV respiration of mitochondria isolated from the livers of young and old mice.

ISSN:0304-324X    

DOI:10.1159/000212036

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

Longevity of eight laboratory strains of the flour beetle Tribolium castaneum, with various geographic backgrounds, was studied under constant laboratory conditions of 33°C and 70% relative humidity in standard medium (95% whole wheat flour and 5% dried yeast) during a period of 227 days starting from the egg stage. The eggs were collected from the same parents, first a few days after emergence and afterwards at intervals of 13, 9, 10 and 11 days. Mean survival time (MST) was found to be strain-specified. It ranges from 128.6 days for KJ (Kyoto, Japan) to 174.2 days for ES (Edinburgh, Scotland). MST was highly correlated with the percentage of adults alive after 227 days, which did not change the ranking order of strain longevity. Parental age had no effect on longevity. The mean adult longevity of the strains was correlated with the available data on adult weight, growth rate, viability and productivity. There was no relationship between adult weight and longevity. Life span was found to depend on growth rate (measured as 13-day larval weight), percent viability (from 13-day larvae to adulthood) and productivity. Developmental time was also found to influence adult life span within certain limits (two extreme strains deviated). The data suggest that ageing and death in T. castaneum is under genetic control and support the idea that ageing, allied to development, is genetically controlled

ISSN:0304-324X    

DOI:10.1159/000212037

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

A total of 483 healthy persons from Czechoslovakia, divided into three age groups (below 40, 41–60 and above 61 years) were examined for eight types of autoantibodies (antibodies to epithelial cells and to colloid of thyroid gland, parietal cell antibodies, antibody to interstitial duct cells of parotis and to adrenal cells, anti-nuclear and anti-mitochondrial antibodies, intrinsic factor antibodies). A significantly increased occurrence was observed in the oldest age group, the results being more manifest in women. A conspicious increase was seen particularly in the thyroid antibodies. The results correspond to those of other authors from different geographic area

ISSN:0304-324X    

DOI:10.1159/000212038

出版商:S. Karger AG    

年代:1975

数据来源: Karger

摘要:

The composition of proteins extracted from tendon collagen is investigated by disc electrophoresis. No qualitative differences can be demonstrated between young and old collagen. The action of formaldehyde and methionine on the tendons has no effect on the electrophoretic picture.

ISSN:0304-324X    

DOI:10.1159/000212039

出版商:S. Karger AG    

年代:1975

数据来源: Karger

ISSN:0304-324X    

DOI:10.1159/000212040

出版商:S. Karger AG    

年代:1975

数据来源: Karger