摘要:

The acid-base characteristics of two peritoneal dialysis solutions containing either lactate or acetate are compared and the time course of changes in intraperitoneal pH following instillation into the abdominal cavity is measured. The concentration of titratable acid (cTA) is 5.58 mmol/l or 7 times as high in solutions containing acetate as in those containing lactate (0.79 mmol/l). The buffer capacity, -dcTA/dpH, is 11.43 and 1.82 mmol/l, respectively. Following intraperitoneal instillation of 1.5 liter of the solutions, the time course is 2–3 times as long before intraperitoneal pH reaches 7 using acetate (18 min) as when using lactate (7 min). The above mentioned difference in acid-base characteristics as well as an individual acetate intolerance is supposed to be the cause for the development of abdominal pains and peritoneal irritation observed in some patients using acetate-containing solutions.123 mmol/l of sodium bicarbonate is to be added to the acetate solution to raise the pH value from 5.6 to 7.4. Neutralization using sodium bicarbonate will thus result in sodium intoxication of the patient. The use of lactate instead of acetate for peritoneal solutions is advocate

ISSN:1660-8151    

DOI:10.1159/000183338

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A boy presenting with a severe congenital nephrotic syndrome diagnosed by histological analysis at the age of 3 weeks was biopsied again 7 years later. The ultrastructural gomerular basement membrane abnormalities depicted in the first biopsy were no longer present in the second one. The number of completely hyalinized glomeruli was not significantly decreased. The GFR remained normal, but a moderate persistent, non-selective proteinuria (800 mg/24 h) was noted without oedema. The patient however developed a progressive perceptive deficit of hearing.

ISSN:1660-8151    

DOI:10.1159/000183339

出版商:S. Karger AG    

年代:1985

数据来源: Karger

摘要:

A new plethysmograph for detecting arterial pulse waves in the rat tail is described. With the objective of indirectly measuring the arterial blood pressure in small animal tails an easy-to-build plethysmographic chamber is presented. Essentially in this apparatus the atmospheric air insulated in the chamber is used as the transmitter of the volume changes caused by the arterial flow. By this methodology details of the pulse wave morphology are clearly visible, including the dicrotic notch. It is demonstrated that this chamber combines simplicity with accuracy.

ISSN:1660-8151    

DOI:10.1159/000183340

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000183341

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000183342

出版商:S. Karger AG    

年代:1985

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000183343

出版商:S. Karger AG    

年代:1985

数据来源: Karger