摘要:

Estrogen-stimulated neurophysin (ESN) was determined by radioimmunoassay in three groups of patients with chronic renal failure: predialysis patients, patients on hemodialysis and patients on continuous ambulatory peritoneal dialysis. ESN levels were significantly elevated in all patients. ESN of these patients is undistinguishable from highly purified pituitary ESN. Immunological and physicochemical analyses of ESN in patients with renal failure suggest that the elevated plasma level is due to a failure of renal clearance. In addition, heterogeneity of urinary ESN, revealed by multiple immunoreactive peaks after gel filtration, indicates altered renal metabolism.

ISSN:1660-8151    

DOI:10.1159/000182903

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

In vitro thyroid function tests were performed on clinically euthyroid patients undergoing regular hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD). The mean serum total thyroxine (TT4) and total triiodothyronine (TT3) values measured before HD were significantly subnormal. Similarly, CAPD subjects had reduced TT3 concentrations with low normal TT4 levels. Free thyroxine measurements, estimated by two different methods were aberrant in CAPD patients. Low normal reverse triiodothyronine (rT3) values were found in HD, in contrast to high normal rT3 levels in CAPD. Thyroid stimulating hormone determinations were normal, corresponding with the euthyroid status in both patient groups.

ISSN:1660-8151    

DOI:10.1159/000182904

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

The sudden onset of hypocalcemia occurring in a patient undergoing hemodialysis led to the diagnosis of spontaneous remission of severe hyperparathyroidism. This was confirmed by a marked reduction in immunoreactive parathyroid hormone level. The hypocalcemia was controlled by 1,25-dihydroxycholecalciferol. A dramatic improvement of hyperparathyroid bone disease, as assessed by radiographic and histomorphometric examination, was observed.

ISSN:1660-8151    

DOI:10.1159/000182905

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Rapidly progressive glomerulonephritis occurred in a woman with rheumatoid arthritis (RA) who had been treated with D-penicillamine for 3 months. Light microscopy study of the kidney showed severe glomerulonephritis with crescent formation in 50% of glomeruli and necrotizing vasculitis. Immunofluorescence revealed IgA and C3 granular deposits diffusely distributed along the capillary walls. The patient was treated with steroid ‘pulse’, antiplatelet agents and heparin and a partial recovery of renal function was observed after 2 months of anuria. This renal picture is unlike that reported in RA and a causative role for D-penicillamine is sugges

ISSN:1660-8151    

DOI:10.1159/000182906

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Renal biopsy specimens from 8 patients with IgA nephropathy (Berger’s disease) were examined immunocytochemically at the light and electron microscopic levels with peroxidase-labeled antibodies to IgA, IgM, J chain and secretory component. In 2 of the 8 specimens heavy deposits of IgA, but no IgM, were found in the mesangium. After acid-urea treatment of these tissue sections, J chain, a subunit of polymeric immunoglobulins, was identified in a distribution similar to that of IgA. In the remaining 6 specimens, small amounts of IgM in addition to denser deposits of IgA and J chains were found. We conclude that the IgA deposits in at least some patients with Berger’s disease consist of IgA polymers linked by J ch

ISSN:1660-8151    

DOI:10.1159/000182907

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Patients with severe lactic acidosis and oliguria who receive large amounts of sodium bicarbonate may develop fluid overload and hyperosmolarity. We infused massive amounts of isotonic sodium bicarbonate and simultaneously removed the excess sodium and water with ultrafiltration if 2 patients with lactic acidosis. The first patient received 1,125 mmol of bicarbonate over 4.5 h with a rise in pH from 7.00 to 7.36 and in HCO3 from 3.5 to 15.7 mmol/l. The second received 968 mmol of bicarbonate over 5.25 h with a rise in pH from 7.00 to 7.27 and in HCO3 from 5.3 to 14 mmol/l. Blood pressure remained stable or rose, electrolytes normalized, excess fluid was removed, and a higher pH was maintained. Isotonic bicarbonate infusion with simultaneous ultrafiltration is a safe and rapid method of correcting the metabolic status of patients with severe lactic acidosis who have not responded to standard therapy.

ISSN:1660-8151    

DOI:10.1159/000182908

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000182909

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000182910

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000182911

出版商:S. Karger AG    

年代:1983

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000182912

出版商:S. Karger AG    

年代:1983

数据来源: Karger