摘要:

IgA1 and IgA2 deposits in the renal glomeruli were studied in 29 biopsy specimens from 17 children with IgA nephropathy and 12 children with anaphylactoid purpura nephritis. IgA1 and IgA2 were detected with the indirect immunofluorescence method, using various combinations of dilutions of sheep antihuman IgA subclass antisera and fluorescein isothiocyanate conjugated rabbit antisheep IgG antiserum. The glomeruli of all the 29 specimens studied were strongly positive for IgA1, while only twelve specimens were positive for IgA2. Ten specimens without IgM deposits were all negative for J chain. These results indicate that the glomerular IgA deposits consist mainly of monomeric IgA1, with a minor share for IgA2. The serum IgA in normal individuals consists of about 90% IgA1 and 10% IgA2. Therefore, it was assumed that the serum IgA is deposited irrespective of subclass in the glomeruli of the patients with IgA nephropathies.

ISSN:1660-8151    

DOI:10.1159/000183059

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

A 39-year-old woman with documented sarcoidosis and membranous glomerulonephritis (GN) with renal failure received a kidney from her identical twin. A few months after transplantation a proliferative GN appeared with hematuria, proteinuria and progressive renal failure over 2 years. Indeed the occurrence of GN in patients with sarcoidosis raises the question of whether the relationship between these two conditions is causal or fortuitous. This report suggests that GN is secondary to sarcoidosis.

ISSN:1660-8151    

DOI:10.1159/000183060

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Tight junctions have not been described in the adult human glomerulus. In a 22-year-old patient with kappa light chain proteinuria, tight junctions were observed between glomerular epithelial cell foot processes (kidney biopsy). The light chain isolated from urine proved to have a relatively high isoelectric point. When the light chain was exposed in vitro to the mucosal surface of a ‘leaky’ epithelium, the Necturus gallbladder, transepithelial resistance and potential difference increased in a concentration-dependent, reversible manner and NaCl dilution potentials decreased, consistent with a reduction in tight-junctional ionic permeability. Gallbladders fixed in situ and freeze-fractured during peak electrophysiological responses revealed an increase in tight-junctional depth. This report indicates that certain light chains, possibly by virtue of a positive charge, may induce changes in epithelial tight junction structure and/or permeabil

ISSN:1660-8151    

DOI:10.1159/000183061

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Experiments were designed to determine whether substance(s) other than electrolytes might activate tubuloglomerular feedback in experimental fulminant hepatic failure. Severe hepatic damage and renal dysfunction were induced by intravenous administration of D-galactosamine. Sera from normal or D-galactosamine-treated rabbits were dialyzed against glucose solution to reduce electrolyte concentrations. Tubuloglomerular feedback response was evaluated in rat nephrons by measuring the early proximal flow rate (EPFR) during orthograde perfusion of the loop of Henle. EPFR was reduced by 28 and 48% with Ringer’s solution and sera from D-galactosamine-treated rabbits, respectively, but was not altered by normal sera. Substance(s) other than electrolytes in the sera from D-galactosamine-treated rabbits might activate the tubuloglomerular feedback to reduce glomerular filtratio

ISSN:1660-8151    

DOI:10.1159/000183062

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Hyporeninemic hypoaldosteronism was observed in an infant at the age of 3 months. Persistent hyperkalemia, hyperchloremic acidosis and salt wasting were present. All abnormal electrolyte values were corrected by the administration of fludrocortisone. Both active and inactive renin were lowered. This infant had also an unexplained spastic quadriplegia and psychomotor retardation. Hyporeninemic hypoaldosteronism should be considered to be one of the causes of salt-losing in infancy.

ISSN:1660-8151    

DOI:10.1159/000183063

出版商:S. Karger AG    

年代:1983

数据来源: Karger

摘要:

Urines of 6 normal subjects, collected during three consecutive 12-hour periods, were examined for proteinuria and albuminuria. During the first period, subjects were kept in the upright position, and during the next two periods in the recumbent position. Both position (upright and recumbent) and the urine collection period (day or night) significantly modify protein and albumin excretion. Proteinuria is more sensitive to different posture and albuminuria to different times of urine collection.

ISSN:1660-8151    

DOI:10.1159/000183064

出版商:S. Karger AG    

年代:1983

数据来源: Karger