摘要:

End-stage kidneys are known to undergo cystic transformation in patients treated with long-term hemodialysis. Little has been published, however, on the occurrence of acquired renal cystic disease (ACD) in renal transplant recipients. The available clinical and histopathological data were gathered on 22 renal transplant recipients who had undergone either necropsy or nephrectomy. None of our patients exhibited cystic changes in their donor kidneys. However, 11 patients (50%) had ACD of the native kidneys while the remaining patients lacked ACD. The duration of dialysis prior to transplantation was significantly longer and the life of the functional transplant kidney was significantly shorter in the ACD group as compared to the noncystic group. The combined duration of ESRD (dialysis + transplantation), however, was comparable in the two groups. It thus appears that the presence of a functioning renal allograft somehow retards the evolution of cystic changes in the diseased native kidneys. 1 of the patients in the ACD group exhibited superimposed multifocal clear cell carcinoma of the affected kidney, while none of the patients in the noncystic group exhibited renal neoplasm.

ISSN:1660-8151    

DOI:10.1159/000183245

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Serum angiotensin-converting enzyme (SACE) was significantly elevated in 16 of 48 patients with various types of chronic renal disease not on hemodialysis [45.6 ± (SD)16.7 nmol/min/ml, p < 0.001] and in 17 of 52 patients with chronic renal disease on maintenance hemodialysis (43.2 ± 13.8, p < 0.001) in comparison with 58 healthy adult controls (32.2 ± 9.8). There was no significant relationship between SACE and renal function as indicated by serum creatinine and creatinine clearance, or the presence or absence of maintenance hemodialysis, except for a transiently increased elevation of SACE immediately post-dialysis due to hemoconcentration. There was a statistically insignificant positive correlation between SACE and 24-hour urinary protein excretion (r = 0.254, n = 21). Mean blood pressure measured in patients on maintenance hemodialysis was inversely related to SACE (p < 0.05) following dialysis. Chronic renal disease irrespective of severity and therapy tends to be associated with elevated SACE and must be considered in the evaluation of sarcoidos

ISSN:1660-8151    

DOI:10.1159/000183246

出版商:S. Karger AG    

年代:1984

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000183247

出版商:S. Karger AG    

年代:1984

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000183248

出版商:S. Karger AG    

年代:1984

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000183249

出版商:S. Karger AG    

年代:1984

数据来源: Karger