摘要:

The incidence of acute tubular necrosis (need for hemodialysis immediately after transplantation) and its severity (the number of days dialysis was needed) were studied in 299 patients who were randomized prior to transplantation into undergoing splenectomy or not having splenectomy. There was no difference in the incidence of acute tubular necrosis between splenectomized and nonsplenectomized patients who received cadaveric grafts or kidneys from living related donors. In those patients in the cadaveric group who had acute tubular necrosis, the duration of need for dialysis was significantly less (p < 0.05) in the splenectomized group (x = 8.9 days) when compared to the nonsplenectomized group (x = 13.2 days). Animal experiments indicate that sustained prostaglandin release may be responsible for the decreased incidence and amelioration of acute tubular necrosis in splenectomized animals. Our study suggests that conclusions made in dogs about the influence of splenectomy on acute tubular necrosis may be applied to humans. Prostaglandin infusion may be a worthwhile method to abolish or ameliorate human acute tubular necrosis.

ISSN:1660-8151    

DOI:10.1159/000183150

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

5 cases of severe acute renal failure caused by ethyl alcohol-induced rhabdomyolysis are reviewed. 4 patients were dialyzed. All patients recovered completely from the renal failure.

ISSN:1660-8151    

DOI:10.1159/000183151

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

Comparative studies were performed on 19 patients who were dialysed initially for a mean of 25 h a week and then for a mean of 11.1 ha week over two 3-year periods. Clinical, biochemical, haematological and neurological valuations were performed, which showed no significant difference. As an adjunct to haemodialysis a perfusion system was added to 12 of these patients already stable on haemodialysis and estimations made of removal of middle molecular weight substances from plasma by a gel filtration method through a Sephadex column. The results of these various techniques are reported and the comparisons between haemodialysis, haemodialysis and ultrafiltration and haemodialysis, perfusion and ultrafiltration are given.

ISSN:1660-8151    

DOI:10.1159/000183152

出版商:S. Karger AG    

年代:1984

数据来源: Karger

摘要:

The design of a dialysate recirculating loop permitted assessment of dialysate/blood Na+ equilibrium which we established as: Na+ plasma water concentration of 143.4 mEq/l and Na+ dialysate concentration of 136.6 mEq/l (Donnan effect). Sodium and water removal using different Na+ dialysate concentrations have been assessed. With an Na+ dialysate concentration of 130 mEq/l plasma clearance of Na+ and H2O are equal, NNa/NH2o = 128–142. Using a dialysate Na+ concentration of 162 mEq/l, NNa/NH2o = 40–61, i.e. Na+ clearance is much lower than H2O clearance. The average patient requires removal of 2 liters H2O and 200 mEq Na+, i.e. NNa/NH2o = 100. This corresponds to an Na+ dialysate concentration of 145 mEq/l. The incidence of hypotensive episodes during dialysis will be reduced if NNa/NH2o ratios (Na+ dialysate concentrations) are individualized for hemodialysis patie

ISSN:1660-8151    

DOI:10.1159/000183153

出版商:S. Karger AG    

年代:1984

数据来源: Karger