摘要:

The relation between renal vein renin activity (RVRA) and renal vein prostaglandin A (PGA) and prostaglandin E (PGE) concentrations was examined in 50 patients with hypertension who underwent renal vein catheterizations for suspected renovascular hypertension. In 14 patients with unilateral renal artery stenosis, mean renal vein PGE concentrations were higher in the renal vein draining the nonischemic kidney, while RVRA was increased in the renal vein draining the ischemic kidney. PGE ratios from the two sides were inversely related to RVRA ratios in this group. In the other 36 patients with either bilateral renal artery stenosis, essential hypertension or nonrenovascular unilateral renal disease, RVRA and PGE concentrations were similar in both kidneys. No relation between RVRA and PGA could be established for any group.

ISSN:1660-8151    

DOI:10.1159/000182019

出版商:S. Karger AG    

年代:1981

数据来源: Karger

摘要:

To test whether angiotensin (All) induces proteinuria via its effect on renal hemodynamics, or by another mechanism, two experimental approaches were used. In the first, it was found that All was as effective in inducing proteinuria in nephrotic as in intact rats. In all All augmented proteinurias, filtration fraction was increased. These effects plus electrophoretic profiles of All proteinuria in intact rats suggested that hemodynamic changes underly the increased glomεrular permeability to protein. In the second approach, the All inhibitor, sar-ala-angiotensin, does not itself induce proteinuria or changes in GFR and RPF, but prevented the hemodynamic responses to All and the proteinuric response as well.

ISSN:1660-8151    

DOI:10.1159/000182020

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000182021

出版商:S. Karger AG    

年代:1981

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000182022

出版商:S. Karger AG    

年代:1981

数据来源: Karger