摘要:

A new 4-antigen recombinant immunoblot assay (4-RIBA) for confirmation of hepatitis C virus (HCV) C-100 enzyme-linked immunosorbent assay (ELISA) reactivity was tested in serum samples of 11 pediatric patients on dialysis. Of 6 HCV C-100 ELISA-positive samples, all were 4-RIBA positive. The 2nd generation ELISA picked up 1 additional case confirmed by 4-RIBA. The 2nd generation tests increased the prevalence of HCV-positive cases.

ISSN:1660-8151    

DOI:10.1159/000186946

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

The serum of 387 hemodialysis patients from 9 dialysis units was checked for anti-hepatitis C virus antibodies with a lst-generation ELISA (Ortho) test: 61 patients were repeatedly positive. In order to avoid false-positive results, these sera were tested with a 1st-generation confirmatory RIB A test, 2nd-generation screening ELISA test and 2nd-generation confirmatory RIBA test. The 2nd-generation ELISA test confirmed data obtained with lst-generation ELISA, however, the 1 st-generation confirmatory RIBA test underestimated the number of anti-HCV-positive patients.

ISSN:1660-8151    

DOI:10.1159/000186947

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Hepatitis C virus (HCV) seems to be the most important agent of non-A, non-B hepatitis. This study was undertaken to assess the prevalence of hepatitis C in our renal unit. Twelve patients (29%) had antibodies against HCV (anti-HCV). Seropositive patients were on hemodialysis for a longer period than seronegatives. Statistically significant associations with anti-HCV were: blood transfusions, at least 1 episode of elevated value of transaminases (2-fold) and fluctuations of transaminases. Our findings confirm the high prevalence of anti-HCV in hemodialyzed patients, the importance of parenteral transmission and the high probability of liver disease in anti-HCV-positive patients.

ISSN:1660-8151    

DOI:10.1159/000186948

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

We have studied a series of 43 patients – who were suffering from uremia, subject to hemodialysis treatment, resulting seronegative to the test for HBV and who had never been vaccinated before – considering the HBS antibody as seroconversion index. We subdivided our patients into three groups, according to the treatment employed. First group: French vaccine; 2nd group: French vaccine + thymopenthine; 3rd group: recombining DNA vaccine + thymopentine. From a statistical point of view, in the 3rd group we obtained a significant seroconversion in terms of patients, if compared with the other gro

ISSN:1660-8151    

DOI:10.1159/000186949

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

The detection of IgG and IgM anti-cytomegalovirus is very important when movements of serum transaminases are noted in absence of positivity for virus of hepatitis in uremic patients on substitutive treatment; in our patients, we have noted a positivity of 67% for the IgG class. Cytomegalic infection must be taken into consideration for the high parenteral transmissibility in addition to the high grade of immunodepression of uremic patients.

ISSN:1660-8151    

DOI:10.1159/000186950

出版商:S. Karger AG    

年代:1992

数据来源: Karger

摘要:

Incidence of seroconversion to anti-HCV from December 1989 to May 1991 was evaluated in patients and in their sexual partners. In December ‘89,13 of 66 and in May ‘91, 26 of 75 patients were HCV positive. 9 of 13 new, seroconverted patients had been transfused. Seroconverted mean dialytic age was lower than that of previous HCV-positive patients. All the sexual partners were HCV negative. Blood transfusion seems to be the main risk factor for HCV infection, while environmental contamination is still debata

ISSN:1660-8151    

DOI:10.1159/000186951

出版商:S. Karger AG    

年代:1992

数据来源: Karger