摘要:

In two patients with polyuria and polydipsia, renal biopsy revealed amyloidosis. Renal function studies showed specific disturbance of water conservation, with relatively intact diluting, acidifying and ammonium excreting capacity. In addition, the second patient had a nephrotic episode which completely disappeared within some months. It is suggested that the observed abnormalities result from selective impairment of water back-diffusion from the collecting ducts, in the presence of a relatively intact glomerular filtration.

ISSN:1660-8151    

DOI:10.1159/000179619

出版商:S. Karger AG    

年代:1968

数据来源: Karger

摘要:

A case of isolated hypoaldosteronism associated with chronic renal failure is reported. Potassium retention and hyperkalemia, sodium wasting, and inability to acidify the urine were all corrected by mineralocorticoid administration. Aldosterone secretion was 86.0 µg/day on a high sodium intake, 30.1 µg/day on a low sodium intake, and 36.2 µg/day after an angiotensin infusion. An important physiologic role is postulated for the hypersecretion of aldosterone usually seen in patients with chronic renal failu

ISSN:1660-8151    

DOI:10.1159/000179620

出版商:S. Karger AG    

年代:1968

数据来源: Karger

摘要:

The effect of sodium balance upon renal renin and renal, adrenal, and salivary gland G-6-PD activity was studied quantitatively and histochemically in the rat. The results indicate a negative sodium balance (sodium deficient diet) induces marked increases in renal renin and G-6-PD content of the kidney and salivary gland. Histochemically, the changes in activity appeared throughout cortical nephrons, markedly so in the macula densa, in the excretory ducts of the salivary glands, and in the adrenal cortex, particularly the zona glomerulosa. Under positive sodium balance (high sodium diet), a marked reduction of G-6-PD activity was observed throughout; renal renin content was similarly reduced. The parallelism between stainable enzyme activity in the macula densa, juxtaglomerular granularity, and total renal G-6-PD and renin content suggests a functional interplay of the structures of the juxtaglomerular apparatus in response to sodium metabolism. Sodium balance also appears to affect enzyme activity of the adrenal cortex and salivary gland excretory ducts, either directly or through hormonal response.

ISSN:1660-8151    

DOI:10.1159/000179621

出版商:S. Karger AG    

年代:1968

数据来源: Karger

摘要:

The effect of eight hours water diuresis on electrolyte excretion and urinary acidification was studied in five permanent inhabitants of a hot region. The experimental design excluded the possible influences of the normal diurnal variations on electrolyte and hydrogen ion excretion. Water diuresis induced a marked increase in ammonia output and decrease in potassium excretion. A significant (p < 0.001) inverse relationship is demonstrated between the net hydrogen ion excretion and potassium output. Glomerular filtration rate, total solute, sodium, chloride, calcium, magnesium, and titratable acid excretion were not appreciably affected. The data presented demonstrate that prolonged water diuresis in permanent inhabitants of a hot region did not appreciably alter the excretion of electrolytes except for a significant fall in potassium output. Its effect on urinary acidification was similar to that previously reported during short term water diuresis.

ISSN:1660-8151    

DOI:10.1159/000179622

出版商:S. Karger AG    

年代:1968

数据来源: Karger

摘要:

Au cours d’une épreuve de Howard, on a étudié chez quatre hypertendus la concentration de divers indicateurs dans des échantillons successifs d’urine pendant la période qui suit leur brusque injection intraveineuse simultanée. L’ordre d’apparition est le suivant: 42K, acide urique 2 14C, P.A.H., inuline (tableau I, fig. 1). L’acide urique 2 14C apparait très près du P.A.H. dans la plupart des expériences. Il est conclu que chez l’homme le tube proximal est perméable à l’acide urique. Les limites de cette tec

ISSN:1660-8151    

DOI:10.1159/000179623

出版商:S. Karger AG    

年代:1968

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179624

出版商:S. Karger AG    

年代:1968

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179625

出版商:S. Karger AG    

年代:1968

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179626

出版商:S. Karger AG    

年代:1968

数据来源: Karger