ISSN:1660-8151    

DOI:10.1159/000181390

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Actuarial statistics of 53 dialysis patients treated between 1965 and 1976 are reviewed. It is suggested that dialysis did not accelerate atherosclerosis over the observed time period. It appears as though a fundamental change in the dialysis population has occurred and there are too few long-term dialysis patients available to establish whether dialysis does accelerate atherosclerosis.

ISSN:1660-8151    

DOI:10.1159/000181391

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

In 28 patients predialysis plasma myoinositol was significantly elevated to 10.8 ± 2.: versus 0.75 ± 0.15 mg/100 ml in normals (mean ± 1 SD), and was weakly correlated with plasm; creatinine concentrations (r = 0.42, p < 0.05). Dialysis decreased plasma myoinositol con centrations to 3.5 ± 1.1 mg/100 ml. In 16 patients studied more extensively plasma myoinosito was similarly elevated to 10.6 ± 3.4 mg/100 ml, and spinal fluid myoinositol was increased t < 9.4 ± 2.3 mg/100 ml (versus 2.7 ± 0.7 in normals, p < 0.001). Nerve conduction velocities wer reduced in 15 and EEG tracings were abnormal in 12 of the 16 patients. However, neither spins fluid nor plasma myoinositol showed any correlation with nerve conduction velocities or EEG changes (r = 0.05–0.20, NS) Myoinositol is one of the substances retained in renal insufficiency but no indication was found that it is a toxin causing uremic neurological dist

ISSN:1660-8151    

DOI:10.1159/000181392

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Using the macrophage migration inhibition test (MIT), a total of 113 patients with various renal diseases, namely glomerulonephritis (GN), were studied for evidence of cell-mediated immunity to various soluble antigens prepared. The positive rate of MIT in the presence of streptococcal antigen, glomerular basement membrane antigen, renal tubulai epithelial antigen and heat-aggregated IgG antigen was 15, 23, 16 and 15%, respectively. Oul of 15 positive patients who were able to be evaluated with those four antigens, 9 cases exhibited cellular hypersensitivity to two or more antigens at the same time. These findings suggest that there is an abnormal cellular response to certain antigen or widespread cell-mediated hypersensitivity to a variety of antigens in certain forms of human GN.

ISSN:1660-8151    

DOI:10.1159/000181393

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Rupture of ten major tendons occurred in 7 out of a total of 50 renal patients treated by chronic hemodialysis, in two renal units. The rupture occurred spontaneously without any special strain. Rupture was complete in five tendons and incomplete in the other five. In 2 cases, rupture occurred simultaneously in both quadriceps tendons. In 1 case a single quadriceps and a triceps brachii tendon were affected together. In 3 cases one quadriceps tendon was affected and in the last case, one triceps brachii tendon alone was ruptured. All the patients suffered from long-standing renal disease with severe secondary hyperparathyroidism. We are anable to explain the high incidence (15%) of this complication in our area. No local factors were found in our study.

ISSN:1660-8151    

DOI:10.1159/000181394

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The effects of a low Na medium on PAH transport, renal morphology, and acetate stimulation of PAH transport have been studied. Low Na inhibits PAH uptake and induces vacuolar formation in tubular cells. Both processes are reversible by reincubating in a high Na medium. Vacuolization appears temperature dependent being much greater at 37 than at 25°C. Acetate uptake consists of a passive and an active component, neither of which is sodium dependent. Acetate stimulation of PAH uptake does, however, require Na. This latter observation suggests that Na may act by altering cell metabolism

ISSN:1660-8151    

DOI:10.1159/000181395

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The effects of saline expansion, parathyroid hormone (PTH) administration and dibutyryl cyclic 3’5’-adenosine monophosphate (DbCAMP) infusion on renal phosphate reabsorption were examined in acutely thyroparathyroidectomized (TPTX), phosphate infused dogs by the recollection micropuncture technique. Saline expansion reduced whole kidney phosphate reabsorption from a mean of 66.1 to 50.4% of filtered load. This response was entirely accounted for by an inhibition of proximal tubular phosphate reabsorption which fell from a mean of 35 to 21 % of the filtered phosphate load. Both PTH and DbCAMP produced a fall in whole kidney phosphate reabsorption comparable to saline. However, this effect was the sum of inhibition of both proximal tubular and distal nephron phosphate reabsorption. These studies demonstrate the important role of the distal nephron in modulating urinary phosphate excret

ISSN:1660-8151    

DOI:10.1159/000181396

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The collagen component of isolated glomerular basement membrane was solubilized by limited pepsin digestion and further purified. The amino acid and carbohydrate composition of the final material was very similar to that described for the α1-chains of type IV collagen. However, the presence of several components was detected when the material was analyzed by sodium dodecyl sulphate-polyacrylamide gel electrophoresis either without or after reduction. The molecular weights of the major components in the reduced material were about 140,000, 100,000, 80,000 and less than 65,000 (in the case of five components). The data thus do not support the previous suggestion that the human glomerular basement membrane contains only one type of collagen polypeptide chain. However, part of the heterogeneity may be due to the presence of more than one collagenous part in a procollagen-type polypeptide chain, and an additional reason may lie in a partial degradation of collagenous portions during pepsin digestion

ISSN:1660-8151    

DOI:10.1159/000181397

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000181398

出版商:S. Karger AG    

年代:1978

数据来源: Karger