ISSN:1660-8151    

DOI:10.1159/000181672

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000181673

出版商:S. Karger AG    

年代:1979

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000181674

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

In an effort to elucidate immunopathogenic mechanisms of membranous nephropathy (MN), freshly collected sera from patients with biopsy proven MN were assayed for circulating immune complexes (ICs) by the Raji cell method and for anti-renal tubular epithelial (RTE) antibodies by a newly established radioimmunoassay (RIA) and by indirect immunofluorescence. 6 of 26 MN patients tested by the Raji cell assay had detectable circulating ICs. However, 5 of these 6 patients had other medical conditions which might also explain the IC reactivity. 29 MN patients and 11 patients with other glomerular diseases had no demonstrable circulating anti-RTE antibodies. This study suggests that if RTE antigens possess a nephritogenic potential for man it is probably only rarely expressed. The inconstant detection of circulating immune complexes in idiopathic MN raises speculation as to their immunopathogenic significance.

ISSN:1660-8151    

DOI:10.1159/000181675

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Rapidly progressive glomerulonephritis is thought to be a proliferative reaction common to a number of disorders. Animal experiments implicate clotting or a product of it as its cause. In the human, the presence of fibrin in crescents, as well as the response to heparinization in some cases, support the role of coagulation in the genesis of extracapillary cell proliferation. We describe the clinical and histologic course in a patient with Wegener’s granulomatosis who presented with a picture of intracapillary clotting which evolved into rapidly progressive glomerulonephritis. The patient had a remarkable return of renal functio

ISSN:1660-8151    

DOI:10.1159/000181676

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

This paper starts a series on red blood cell (RBC) metabolism in patients with chronic renal failure (CRF). The glycolytic enzyme levels and in vitro half-lives of these patients’ RBCs were determined. A number of enzymes (hexokinase, glucose-6-phosphate isomerase, fructose-6-phosphate kinase, aldolase, glyceraldehyde-3-phosphate dehydrogenase and lactate dehydrogenase) showed higher activities than in normal control RBCs. Other enzyme activities were normal. These results were discussed and several possible mechanisms considered. We favour the point of view of a shortened life span of the RBCs in CRF, making the most unstable enzymes of the glycolytic sequence appear increased as compared with normal control

ISSN:1660-8151    

DOI:10.1159/000181677

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

A detailed histological assessment of the 1-hour posttransplant biopsy has been made in 65 cadaver and related renal transplants. There was a lack of correlation between the numbers of polymorphonoclear leucocytes per glomerulus, the presence and severity of thrombi, vascular changes, interstitial scars, the presence or absence of immune deposits, and the renal function of the patients at 90,180 and 365 days. The only positive finding was a statistically significant correlation between the glomerular tamponade at 90 days and the renal function. This was not borne out at 180 and 365 days.

ISSN:1660-8151    

DOI:10.1159/000181678

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

54 biopsy cylinders of patients with different chronic sclerosing interstitial nephritides were investigated morphometrically. The point-counting method was used to determine the relative interstitial volume of the renal cortex. In this study, as in earlier investigations on inflammatory and noninflammatory glomerular diseases, as well as in studies on benign nephrosclerosis, significant positive correlations could be found between serum creatinine concentration and enlargement of the interstitium induced by fibrosis. Furthermore, correlations between decreasing serum creatinine clearance and fibrosis-induced interstitial broadening could be established. Enlargement of the interstitium by lymphocytic and plasma cellular infiltrates had no influence on renal function. Only in 1 patient were the findings not congruent with the above-mentioned observations. This could be explained by a severe anorexia nervosa with muscular atrophy and lack of available creatinine. The clearance values, however, showed the expected impairment of renal function. Interstitial fibrosis may lead to a narrowing of the postglomerular vessel network and to an elevated postglomerular flow resistance. In spite of increased glomerular filtration pressure, slowing of the glomerular blood flow could lead to an elevated serum creatinine concentration. A reduced glomerular filtration rate could lead to tubular atrophy as a sign of inactivity. Furthermore, the deficient Na-Cl resorption in atrophic tubules most likely perpetuates the decrease in the glomerular filtration rate. The glomerular filtration rate could be diminished by the so-called Thurau mechanism.

ISSN:1660-8151    

DOI:10.1159/000181679

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

Peritoneal clearances were measured in multiple patients with different types of peritoneal dialysis solution to assess the effects of pH, choice of buffer anion (acetate versus lactate), and the effects of nitroprusside (a vasodilator) in combination with different buffer anions and varying pH. The studies show no differences in peritoneal clearances at very low solution pH (less than 6 as is commonly available) as compared to a pH nearer to 7 or above. There were no differences between solutions with acetate as compared to those with acetate. Nitroprusside significantly increased clearances in all solutions to a similar extent.

ISSN:1660-8151    

DOI:10.1159/000181680

出版商:S. Karger AG    

年代:1979

数据来源: Karger

摘要:

In 196 adult patients with chronic renal disease or primary hypertension, the evaluation of glomerular filtration rate (GFR) by means of creatinine clearance, ‘predicted’ creatinine clearance and [125I]-iothalamate clearance was performed. Tothalamate clearance was evaluated after subcutaneous injection of the substance. In patients with normal or upper borderline plasma creatinine values, the iothalamate clearance ranged from 44 to 117 ml/min/1.73 m2 and the overestimation of GFR from creatinine clearance was negligible. In patients with mild or advanced renal failure, the overestimation of GFR from creatinine clearance increased up to 18 and 32%, respectively. The clinical usefulness of iothalamate clearance is evident especially in patients with mild renal failure, in whom an accurate evaluation of GFR is often important for a correct dietary and therapeutic appro

ISSN:1660-8151    

DOI:10.1159/000181681

出版商:S. Karger AG    

年代:1979

数据来源: Karger