摘要:

The response to rapid infusion of 2.5% saline solution was examined in 21 patients 1–15 years after an episode of acute poststreptococcal glomerulonephritis. 12 were normotensive and 9 hypertensive; 11 had minimal proteinuria; renal biopsies showed varying degrees of glomerular sclerosis in 9 and were normal in the remainder; filtration rates ranged from 151 to 26 ml/min. Exaggerated natriuresis during the saline load occurred in 19 of the 21. The occurrence or magnitude of natriuresis was not dependent on the level of filtration rate or the presence of hypertension. The renal mechanism, which could not be attributed to increase in filtration rate, decrease in peritubular oncotic pressure, or increase in intrarenal pressure, is unexplained. It is suggested that this remarkably altered reactivity to saline loading reflects the presence of diseased nephrons and constitutes further evidence that irreversible renal damage occurs commonly following acute poststreptococcal glomerulonephriti

ISSN:1660-8151    

DOI:10.1159/000180411

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Fasting and 1 - 2-, 3- and 4-hour plasma phenylalanine levels following 50 mg/kg oral phenylalanine administration were increased above normal values in uremic patients. Plasma tyrosine concentrations, however, were not significantly different from normal values. The rate of plasma disappearance of phenylalanine was significantly longer in nondialyzed patients when compared to normal subjects and dialyzed uremics. These observations indicate that phenylalanine metabolism is altered in uremia.

ISSN:1660-8151    

DOI:10.1159/000180412

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Dialysis fluid containing a low concentration of magnesium ( ≤ 0.05 mmol/l) was used to treat 17 patients on maintenance haemodialysis for varying periods of time up to 5 years. Mean plasma and ultrafiltrable magnesium concentrations measured in these patients before haemodialysis did not differ significantly from control values; after dialysis, plasma and ultrafiltrable magnesium concentrations were reduced only temporarily. Erythrocyte magnesium concentrations were elevated both before and after haemodialysis: dialysis did not significantly alter the mean concentrations. There was no significant correlation between the length of time on maintenance haemodialysis and either plasma or erythrocyte magnesium levels. As the mean magnesium concentration of bone biopsy specimens was also significantly greater than the mean from the control subjects, there was no evidence that magnesium depletion had been produced in these dialysis patient

ISSN:1660-8151    

DOI:10.1159/000180413

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Arterial plasma renin activity (PRA) was measured using radioimmunoassay techniques in pentobarbital-anesthetized dogs. Acute saline loading (40–60 ml 150 mM NaCl/kg body weight, or 20 ml 300 mM NaCl/kg body weight, i. v.) reduced PRA from control level in 7 dogs. Despite continued increases in filtered and excreted masses of Na, subsequent partial aortic clamping increased PRA in proportion to the degree of reduction in renal perfusion pressure. In 6 other dogs aortic clamping superimposed on total ureteral occlusion led to changes in PRA which were inversely associated with renal perfusion pressure. These results suggest a controlling mechanism for renin secretion sensitive to some hemodynamic paramete

ISSN:1660-8151    

DOI:10.1159/000180414

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Urinary sodium and phosphate excretion were studied in normotensive and hypertensive individuals during prolonged infusion with normal saline before and after the addition of 10% glucose. The results show a dichotomy between the enhanced fractional sodium excretion in the hypertensive subjects and the fractional phosphate excretion, which tended to be lower in this group than in normotensive subjects. These findings suggest an alteration of distal sodium reabsorption as the cause of the ‘exaggerated’ natriuresis of hypertensive subjects following saline infus

ISSN:1660-8151    

DOI:10.1159/000180415

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Acute renal insufficiency was observed in two patients bitten by Russell’s vipers. Both patients had bleeding symptoms presumably due to disseminated intravascular coagulation. There was mild intravascular hemolysis. The serum β-1 C globulin was decreased in both cases. Renal biopsy showed tubular necrosis and arteritis. By immunofluorescent study deposition of β-1 C globulin was noted in the arterial lesion, the glomerular mesangium, and the arteriolar wall. Immunoglobulin and fibrin deposits could not be detec

ISSN:1660-8151    

DOI:10.1159/000180416

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Alport’s syndrome is a glomerulopathy of unknown pathogenesis that should be considered in any patient with unexplained hematuria. Four new kindreds of carefully studied family backgrounds were investigated; renal functional tests, otorhinolaryngological and ophthalmological tests, chromosomal maps, light and immunofluorescent microscopic studies were carried out. Renal biopsies of three male patients were also examined by electron microscopy. Characteristic ultrastructural lesions were found: the basement membrane showed segmentary thickenings with characteristic focal and local splitting of the lamina densa, giving rise to electron-lucent space

ISSN:1660-8151    

DOI:10.1159/000180417

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

600 acute hemodialyses have been performed by a simplified method of percutaneous femoral vessel can nulation utilizing special equipment. Because skin incision was not required, repeated cannulation of femoral vessels was feasible. Blood was returned via small caliber, low resistance needle sets in peripheral veins. Where peripheral veins were inadequate, two femoral vessel cannulas or a ‘unipuncture’ femoral cannula were u

ISSN:1660-8151    

DOI:10.1159/000180418

出版商:S. Karger AG    

年代:1974

数据来源: Karger