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1. |
Balkan Endemic Nephropathy: More Questions than Answers |
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Nephron,
Volume 62,
Issue 1,
1992,
Page 1-5
Philip W. Hall, 3rd,
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ISSN:1660-8151
DOI:10.1159/000186985
出版商:S. Karger AG
年代:1992
数据来源: Karger
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2. |
Cystic Radiolucencies of Carpal Bones, Distal Radius and Ulna as a Marker for Dialysis-Associated Amyloid Osteoarthropathy |
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Nephron,
Volume 62,
Issue 1,
1992,
Page 6-12
Noriyuki Hommaa,
Fumitake Gejyo,
Hirohito Kobayashi,
Hidehiko Saito,
Shinji Sakai,
Masashi Suzuki,
Yoshihei Hirasawa,
Masaaki Arakawa,
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摘要:
Patients on long-term hemodialysis (HD) are known to develop amyloid osteoarthropathy, evidenced as cystic radiolucencies on X-rays of the affected joints. To study the relationship between cystic radiolucencies and amyloid osteoarthropathy in 394 patients, we classified the severity of the cystic radiolucencies seen in the wrist joint on a 4-point scale and evaluated the association between lesion severity (grade) and several parameters. Biopsy was performed in 8 patients with 11 bone cysts of the wrist joint who had been operated for carpal tunnel syndrome. HD for 10 years or longer, age 50 or older and the presence of carpal tunnel syndrome were associated with severe cyst rating. There was no association between lesion grade and serum level of PTH-C, aluminum or β2-microglobulin (B2M). Ten of the 11 biopsied bone cysts in 8 patients with carpal tunnel syndrome demonstrated amyloid deposits which reacted with B2M. We conclude that a cystic radiolucency observed in the wrist joint of a patient undergoing HD indicates the deposition of amyloid. The cyst grade provides a useful marker for the severity of amyloid osteoarthropathy in HD patients
ISSN:1660-8151
DOI:10.1159/000186986
出版商:S. Karger AG
年代:1992
数据来源: Karger
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3. |
Low Molecular Weight Heparin (CY-216) versus Unfractionated Heparin in Chronic Hemodialysis |
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Nephron,
Volume 62,
Issue 1,
1992,
Page 13-17
Enric Grau,
Florencio Sigüenza,
Francesc Maduell,
Mariano Linares,
Angels Olaso,
Ricart Martinez,
Antonio Caridad,
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摘要:
In 14 patients undergoing chronic hemodialysis, we investigated the safety and efficacy of the low molecular fragment (CY-216) in comparison to unfractionated heparin (UFH) in the prevention of clotting in the extracorporeal circuit (ECC). In this study, 168 hemodialysis sessions were undertaken with UFH in 2 bolus doses (5,437 ± 1,477 SD IU) and 231 with CY-216 in a single bolus dose [initial dose 150 anti-Xa U Institut Choay (IC)&slash;kg]. There were no clots in the bubble trap in any UFH sessions, and 14.8% had coagulated fibers in the dialyzer. Clotting in the bubble trap was observed in 2 CY-216 sessions (0.8%) and coagulated fibers in 22.6% of the sessions. At the end of the study, the mean dose of CY-216 was 250 anti-Xa UlC/kg but a dose of 350 anti-Xa UlC/kg was needed in the 2 patients treated by recombinant human erythropoietin. Anti-Xa levels at the end of the runs were higher (0.47 ± 0.1 U/ml) in the CY-216 group than in the UFH group (0.28 ± 0.1 U/ml). There was a correlation between anti-Xa levels and efficacy in the CY-216 group. An anti-Xa activity above 0.4 U/ml was needed in order to minimize thrombus formation. Antithrombin III-protease complexes (ATM) and D dimer fibrin derivatives (D dimer) were used as thrombotic markers but they were of little value for the detection of fibrin formation in the ECC. Our findings suggest that CY-216 administered as a single bolus dose seems to be of similar effectiveness to U
ISSN:1660-8151
DOI:10.1159/000186987
出版商:S. Karger AG
年代:1992
数据来源: Karger
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4. |
Amino-Aciduria and Enzymuria in Patients with Artificial Heart Valves |
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Nephron,
Volume 62,
Issue 1,
1992,
Page 18-21
Patricia C.K. Chan,
W.H. Chow,
Sidney C.F. Tam,
Ignatius K.P. Cheng,
M.K. Chan,
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摘要:
Fifteen patients with artificial heart valves and evidence of chronic intravascular haemolysis were studied for proximal tubular dysfunction. Three patients had haemosiderinuria and haemoglobinuria; 2 had haemoglobinuria alone. Increased urinary amino acid nitrogen occurred in 8, raised fractional β2-microglobulin excretion in 2, hypophosphataemia in 4, renal glycosuria in 1 and enhanced fractional urate excretion in 1. Urinary N-acetyl-β-glucosaminidase (NAG) excretion increased in 7; the mean urinary NAG/creatinine ratio was raised to twice the upper limit of the normal range. Renal haemosiderosis due to chronic intravascular haemolysis could cause tubular injur
ISSN:1660-8151
DOI:10.1159/000186988
出版商:S. Karger AG
年代:1992
数据来源: Karger
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5. |
Plasma Levels of the Anaphylatoxins C3a and C4a in Patients with IgA Nephropathy/Henoch-Schönlein Nephritis |
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Nephron,
Volume 62,
Issue 1,
1992,
Page 22-26
H.H.A. Abou-Ragheb,
A.J. Williams,
C.B. Brown,
A. Milford-Ward,
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摘要:
Measurements of plasma anaphylatoxins C3a and C4a were carried out as an indicator of in vivo complement activation in 46 patients suffering from IgA nephropathy/Henoch-Schönlein nephritis. There was a significant correlation between plasma levels of C4a and plasma creatinine and urea. We also found a significant correlation of plasma levels of C3a with plasma creatinine. We propose that the measurement of anaphylatoxin levels provides a sensitive indicator of in vivo complement activation and may serve as an additional method for monitoring the progress of disease in these patients
ISSN:1660-8151
DOI:10.1159/000186989
出版商:S. Karger AG
年代:1992
数据来源: Karger
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6. |
Inhibition of Vascular Permeability Factor Production by Ciclosporin in Minimal Change Nephrotic Syndrome |
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Nephron,
Volume 62,
Issue 1,
1992,
Page 27-30
K. Maruyama,
S. Tomizawa,
Y. Seki,
H. Arai,
T. Kuroume,
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摘要:
In order to ascertain whether ciclosporin (Cs) has an inhibitory effect on the vascular permeability factor (VPF) production, various quantities of Cs were added to T lymphocyte cultures from 8 children with minimal change nephrotic syndrome (MCNS) and the VPF activity of culture supernatants was assayed. As a result of the addition of Cs, a dose-dependent inhibition of VPF production was seen. VPF production was inhibited by a level of between 100 and 250 ng/ml of Cs in vitro. The reduction of proteinuria by Cs in MCNS might be due to the inhibition of VPF production.
ISSN:1660-8151
DOI:10.1159/000186990
出版商:S. Karger AG
年代:1992
数据来源: Karger
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7. |
Lipids in the Progression of Chronic Renal Failure |
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Nephron,
Volume 62,
Issue 1,
1992,
Page 31-35
P. Cappelli,
M. Evangelista,
M. Bonomini,
P.F. Palmieri,
A. Albertazzi,
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摘要:
Lipid disturbances have been linked to the progression of chronic renal disease. We examined 52 patients with a creatinine clearance (CCr) of 38.5 ± 7.9 ml/min due to various nephropathies, on free diet. Bimonthly, over a 12-month period, we assessed: serum creatinine (Cr); CCr; daily urinary urea excretion; urinary protein excretion per unit of residual renal function (UProt/CCr); total, HDL, VLDL and LDL cholesterol; triglycerides; Apo A, Apo B. Chronic renal failure was progressive in 22 patients with a slope of 1/Cr-0.00358 ± 0.00247, stable in 30 with a slope of 0.00420 ± 0.00285. Lipid parameters did not differ significantly between the two groups but for the lower Apo A and Apo A/Apo B ratio values in the progressive group. Overall slope inversely correlated with basal CCr; in the progressive patients the slope correlated with the percentage variation of UProt/CCr and only partially with the altered Apo profi
ISSN:1660-8151
DOI:10.1159/000186991
出版商:S. Karger AG
年代:1992
数据来源: Karger
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8. |
Glycosaminoglycans in Urolithiasis |
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Nephron,
Volume 62,
Issue 1,
1992,
Page 36-39
A. Nesse,
G. Garbossa,
M.C. Romero,
C.E. Bogado,
J.R. Zanchetta,
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摘要:
To determine if there are differences in urinary glycosaminoglycan (GAG) concentrations, 43 stone-forming patients and 37 healthy control subjects of both sexes were studied. Urinary concentrations of calcium, magnesium, creatinine, uric acid and GAGs were determined. GAGs were measured by the Di Ferrante precipitation procedure followed by the Bitter and Muir reaction. Urinary GAG concentration and daily output were significantly lower in stone-forming patients. The present study clearly demonstrates the decreased urinary GAG concentration and excretion in stone-forming patients and suggests an interaction between GAGs and urate that could modify the inhibitory potency of GAGs.
ISSN:1660-8151
DOI:10.1159/000186992
出版商:S. Karger AG
年代:1992
数据来源: Karger
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9. |
Effect of Simvastatin on Qualitative and Quantitative Changes of Lipoprotein Metabolism in CAPD Patients |
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Nephron,
Volume 62,
Issue 1,
1992,
Page 40-46
C. Wanner,
I. Lubrich-Birkner,
O. Summ,
H. Wieland,
P. Schollmeyer,
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摘要:
The efficacy of simvastatin, a competitive inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase, was investigated in 12 patients treated with continuous ambulatory peritoneal dialysis (CAPD), displaying hypercholesterolemia and moderate hypertriglyceridemia. After a 4-week placebo period, simvastatin was administered in increasing doses over a period of 3 months (1st month 10 mg; 2nd month 20 mg and 3rd month 40 mg day-1). Simvastatin reduced total serum cholesterol (300.0 + 15.5 vs. 193.0 ± 8.0; -35%), LDL cholesterol (203.8 ± 13.0 vs. 104.7 ± 6.0; -48.0%) as well as apolipoprotein B (132.3 ± 6.6 vs. 77.8 ± 2.7 mg/dl; -40%). Furthermore, the ratio of LDL apo B/LDL cholesterol increased significantly (0.55 ± 0.016 vs. 0.64 ± 0.027). Another remarkable effect was the reduction of cholesterol concentration in VLDL (47.8 ± 5.6 vs. 30.4 ± 5.2; -35%). Therefore, the ratio of triglycerides/cholesterol in VLDL increased (3.57 ± 0.3 vs. 4.28 ± 0.29), indicating VLDL formation poor in cholesterol and rich in triglycerides. However, HDL cholesterol increased significantly from 48.6 ± 4.4 to 57.9 ± 5.3 mg/dl (23%). Lipoprotein(a) levels were increased as compared to controls (420 ± 73 vs. 145 ± 26 U/l), but were not influenced significantly by simvastatin treatment (539 ± 99 U/l, 3rd month). No evidence for notable clinical side effects and laboratory abnormalities were reported. Measurement of simvastatin plasma levels 12 h after drug administration (single dose 40 mg) showed no detectable plasma values. At present, it appears that CAPD patients with high serum cholesterol are good candidates for the treatment with HMG-CoA reduc
ISSN:1660-8151
DOI:10.1159/000186993
出版商:S. Karger AG
年代:1992
数据来源: Karger
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10. |
A Case of POEMS Syndrome Showing Elevated Serum Interleukin 6 and Abnormal Expression of Interleukin 6 in the Kidney |
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Nephron,
Volume 62,
Issue 1,
1992,
Page 47-51
Atsushi Fukatsu,
Yasuhiko Ito,
Yukio Yuzawa,
Futoshi Yoshida,
Masataka Kato,
Kouichirou Miyakawa,
Seiichi Matsuo,
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摘要:
A 46-year-old female presented with POEMS syndrome. Hemodialysis was initiated to control severe anasarca and declining renal function. Corticosteroids were effective in treating renal insufficiency and other symptoms. Serum interleukin 6 (IL-6) was elevated before the corticosteroid therapy but returned to the normal level under the therapy. Immunostaining for the kidney tissue obtained by a renal biopsy showed a diffuse distribution of IL-6 in the glomeruli; thus, in contrast to normal, IL-6 was detected not only in mesangial cells but also in endothelial cells. IL-6 was also distributed in capillaries in the interstitium. While these results suggest a pathogenic role of IL-6 in POEMS syndrome, other factors may be necessary for the full expression of symptoms. Furthermore, it is suggested that chronically stimulated glomerular endothelial cells are capable of producing IL-6.
ISSN:1660-8151
DOI:10.1159/000186994
出版商:S. Karger AG
年代:1992
数据来源: Karger
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