ISSN:1660-8151    

DOI:10.1159/000181373

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

70 cases of focal glomerulosclerosis (FGS) followed for periods ranging from 1 to 24 years are reported. 39 patients had a nephrotic syndrome. 31 patients had asymptomatic proteinuria. 97 renal biopsies were performed. At least one biopsy specimen from every patient showed focal and segmental involvement of glomeruli, but no lesions were observed on the first biopsy in 6 patients. 26 of the 35 patients with a nephrotic syndrome were treated with steroids alone and/or chemotherapy and/or indomethacin. Resistance to treatment was encountered in 21 patients. Complete remission was observed in 6 cases, despite persistence or accentuation of histological lesions on serial biopsies in 3 cases. Actuarial renal survival rate at 10 years was 45% in the group with a nephrotic syndrome versus 91 % in patients with proteinuria. FGS with a persistent nephrotic syndrome represents the ‘malignant’ form of the disease. Recurrence of the disease was observed after transplantation in 2 cases and was absent i

ISSN:1660-8151    

DOI:10.1159/000181374

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Technetium-99m-polyphosphate bone scintigraphy was performed in 105 kidney-transplanted patients. The pathological scintigraphic changes were classified as either (1) generalized, symmetrical or (2) focal accumulations of the tracer in the bones. 40 of the patients had normal scintigrams. 18 patients had generalized symmetrical scintigraphic changes alone, while focal scintigraphic changes were found in 14 patients without generalized changes and 33 patients had generalized as well as focal changes. The severity of the scintigraphic findings correlated to the results of the transplantation, i.e. the total dose of prednisone, the number of rejection episodes and the creatinine clearance at the time of scintigraphy. Compared to patients on hemodialysis a less frequent appearance of generalized scintigraphic changes was found in kidney-transplanted patients, suggesting that the frequency of renal osteodystrophy decreases after a successful transplantation. The more frequent appearance of focal changes after a kidney transplantation suggests that a bone disease of a different etiology now is superimposed. As both types of scintigraphic changes showed highly significant correlations to the total dose of prednisone, it is concluded that glucocorticoid treatment is an important etiological factor in the development of focal bone lesions and may contribute to the maintenance of generalized skeletal lesions after a kidney transplantation.

ISSN:1660-8151    

DOI:10.1159/000181375

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The in vitro incorporation of 3H-thymidine, 3H-uridine and 3H-leucine, reflecting the synthetic capacity for DNA, RNA and protein, respectively, was detected by radioautography in the erythroid precursors of 10 patients with chronic renal failure. The results were compared with the uptake of the isotopes in the erythroid precursors of healthy subjects. The pattern of incorporation for all three isotopes in the patients’ cells was similar to that of control cells, but significantly lower. The possible causes of this difference are discusse

ISSN:1660-8151    

DOI:10.1159/000181376

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

Cardiac output (CO) and renal blood flow (RBF) were simultaneously evaluated (microsphere method) in awake rats, 3, 6, and 24 h after induction of acute renal failure by mercuric chloride (HgCl2; 4.7 mg/kg body weight). 3 h after injection of HgCl2 CO and RBF decreased to 77 and 72% of respective control values of 32.0 ± 2.4 and 4.65 ± 0.44 ml/min/100 g. Renal vascular resistance (RVR) and total peripheral resistance (TPR) were significantly increased compared to control at this time. Similar results were observed 6 h after administration of HgCl2. Volume expansion with plasma (2% of body weight) restored CO, RBF, TPR, and RVR to normal 3 h after injection of HgCl2. Despite significantly elevated blood urea nitrogen 24 h after injection of HgCl2 (103.7 mg%), all hemodynamic parameters were within control range. Plasma volume was normal 3 h after HgCl2 but was significantly elevated compared to control 24 h after HgCl2 (4.73 vs. 3.92 ml/l00 g, p < 0.01). These findings indicate that factors other than preferential renal vasoconstriction may be involved in the transient renal ischemia of HgCl2-induced acute renal failur

ISSN:1660-8151    

DOI:10.1159/000181377

出版商:S. Karger AG    

年代:1978

数据来源: Karger

摘要:

The effect of ischemia on renal blood flow (RBF) in the rat has been an unsettled question. This study used a totally extractable indicator, radioactive microspheres, with a reference arterial sample, to study RBF quantitatively 10 and 60 min after 1 h of unilateral renal artery clamping in anesthetized, heparinized rats. The results indicate that after release of the arterial clamp, the kidney is enlarged and exhibits an increase in renal vascular resistance. RBF to the contralateral non-ischemic kidney is not different from that of a time-control series.

ISSN:1660-8151    

DOI:10.1159/000181378

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000181379

出版商:S. Karger AG    

年代:1978

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000181380

出版商:S. Karger AG    

年代:1978

数据来源: Karger