摘要:

Renal hemodynamics, sodium and water excretion were studied in six sea level residents and eight high altitude (4,500 m) natives before, during and after the infusion of small amounts of angiotensin (0.32 µg/min). In basal conditions the high altitude group showed a mild reduction in the glomerular filtration rate, with a higher reduction in the renal plasma flow and a normal or slightly increased renal blood flow. During angiotensin infusion, both sea level and high altitude groups responded with a marked reduction in urine flow and sodium excretion. The glomerular filtration rate and renal plasma flow diminished with a greater fall in the latter. This changes were slighter in the high altitude group, except in the sodium to inulin clearance ratio, which was similar in both groups. Despite a high filtration fraction, the kidney of the high altitude native responds to angiotensin like the sea level kidney. These results are discussed in relation to the paradoxical renal response to angiotensin observed in the hypertensive patient

ISSN:1660-8151    

DOI:10.1159/000179851

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Chez le chien anesthésié, en étudiant les variations de la sécrétion de rénine dans des conditions précises, nous avons tenté de dissocier les facteurs jouant sur les cellules juxtaglomérulaires de ceux agissant sur la macula densa. L’activité-rénine dans le sang veineux rénal, le débit sanguin rénal, la pression artérielle moyenne rénale ont été mesurés simultanément. Voici nos résultats: (a) Dans la zone d’autorégulation du débit sanguin rénal, la sécrétion de rénine est inversement proportionelle à la pression artérielle moyenne; mais cette sécrétion baisse pour une pression de perfusion rénale inférieure à 50 mm Hg. (b) L’augmentation progressive de la pression intra-urétérale entraîne des variations de la sécrétion de rénine s’exprimant en une courbe triphasique, cependant que le débit sanguin rénal et la pression artérielle ne diminuent pas. (c) Une hypersécrétion de rénine apparaît dans les minutes suivant l’injection de Furosémide. Au contraire, une perfusion de Na Cl à 10% entraîne une chute de la sécrétion de rénine. Dans ces deux dernières conditions expérimentales, des mécanismes baroceptifs ou voloréceptifs peuvent être exclus. Le contrôle de la secretion de rénine semble done être bipolaire, faisant int

ISSN:1660-8151    

DOI:10.1159/000179852

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

A fluorescent antibody method of staining the juxta glomerular cells (JG-cells) of wax-embedded renal tissue, initially prepared by freeze-substitution, was developed. Specimens of antisera to pig renin, specially absorbed by low-renin pig kidney powder stained only the granules of the JG-cells of the pig kidney. These antisera also cross-reacted with the JG-granules of dog and rabbit. When plasma globulins were elevated in the dog, globulin deposits could be stained with conjugated antibodies to canine globulins inside the JG-cells. Because of this finding the JG-cells were judged to be highly permeable to plasma constituents and perhaps angiotensinogen.

ISSN:1660-8151    

DOI:10.1159/000179859

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

Serum K concentration is usually normal or moderately elevated in chronic renal insufficiency. Severe hyperkalemia, disproportionate to the degree of renal deficiency, has been frequently observed in chronic pyelonephritis; its pathogenesis is still unknown. Marked elevation of serum potassium was observed in a patient with chronic pyelonephritis and simultaneous selective deficiency of aldosterone. The hyperkalemia was corrected by mineralocorticoid replacement therapy. In some cases of chronic pyelonephritis selective aldosterone deficiency may be responsible for the marked hyperkalemia.

ISSN:1660-8151    

DOI:10.1159/000179860

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

During mercurial intoxication produced by the intraperitoneal injection of 10 mg of mercury as mercaptomerine, total LDH activity decreases in the superficial and deeper cortex of the kidney. Increased LDH levels are seen in blood plasma while measurable amounts appear in the urine. The LDH isoenzyme pattern of the cortex – which contains predominantly the aerobic LDH1 and LDH2 fractions – shows a small relative increase of the anaerobic LDH5 fraction, visible after 24 h. Total LDH activity of inner medulla remains unchanged, its isoenzyme pattern, however, which normally contains predominantly LDH4 and LDH5 fractions, shows a shift towards an increase of the LDH1 and LDH2 fractions; these modifications are already present after 4 h. Changes in LDH isoenzyme pattern can be the expression of a disproportional loss or breakdown of the individual LDH fractions from the cells; they can also reflect a cellular adaptation to changed metabolic conditions. These possibilities are considered for the LDH1 and LDH2 increase seen in the LDH isoenzyme pattern in the inner medulla during mercury intoxication and for the LDH5 increase in superficial cortex 24 h after injection of merc

ISSN:1660-8151    

DOI:10.1159/000179861

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

A reverse osmosis plant for preparation of dialysis water is described. With a total cellulose acetate membrane area of 1.8 m2 and a high flow rate of the water across the membrane a filtrate production of about 500 ml/min was obtained at a mechanical pressure of about 35 atmospheres. This is adequate for long-term dialysis of one patient. The capacity can be increased at will by extending the membrane area or by serial arrangement of 2 or more columns. After 6 h of continous operation the filtrate had a calcium concentration below 0.6 mEq/l (on an average 0.3 mEq/l), a sodium concentration below 0.5 mEq/l, and a conductivity of 20–60 //mho. The filtrate was sterile and pyrogene-free. The apparatus is easy to work and proved to be safe and cheap to ru

ISSN:1660-8151    

DOI:10.1159/000179862

出版商:S. Karger AG    

年代:1970

数据来源: Karger

摘要:

The radiological findings of sixty poorly functioning shunts are analysed. Details of the technique used are given together with illustrations of the main lesions. The help gained from arteriovenography of shunts is assessed and it is concluded that the radiology of shunts is helpful in their management.

ISSN:1660-8151    

DOI:10.1159/000179863

出版商:S. Karger AG    

年代:1970

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179864

出版商:S. Karger AG    

年代:1970

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179865

出版商:S. Karger AG    

年代:1970

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000179866

出版商:S. Karger AG    

年代:1970

数据来源: Karger