ISSN:1660-8151    

DOI:10.1159/000180885

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000180886

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000180887

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000180888

出版商:S. Karger AG    

年代:1977

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000180889

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

In three patients with Bartter’s syndrome, indomethacin administration resulted in the disappearance of the hypokalemic alkalosis and in a normalization of the elevated plasma renin activity. Changes in calcium and phosphate metabolism during indomethacin medication seemed to indicate an increase in reabsorption activity of the renal proximal tubulus. A kidney biopsy performed in one of the patients showed, besides hyperplasia of juxtaglomerular cells, hyperplasia of interstitial medullary cells which are presumed to produce prostaglandins. As indomethacin is a well-known inhibitor of prostaglandin synthesis, the observations suggest that an overproduction of renal prostaglandins could well be of pathogenetic significance in Bartter’s syndr

ISSN:1660-8151    

DOI:10.1159/000180890

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

The dialysis clearance of guanidinosuccinic acid (GSA) was measured in vitro and in vivo in patients undergoing maintenance hemodialysis. The in vitro (44 ± 5 [SEM] ml/min) and in vivo (40 ± 7 ml/min) clearances were similar to and lower than those of urea and creatinine. Plasma GSA concentrations predialysis (210 ± 49 µg/100 ml) were higher than those of controls ( < 40 µg/100 ml) and decreased substantially at the end of a single hemodialysis (percent decrease: 53 ± 5). Marked increase of plasma GSA concentrations 12 h postdialysis were found in only two cases. An attempt was made to derive a single curve predicting plasma GSA decline during dialysis using the data obtained in these patients. The removal data suggest that the space of distribution of GSA approximates the extracellular fluid v

ISSN:1660-8151    

DOI:10.1159/000180891

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Juxtaglomerular cell count (JGCC) and juxtaglomerular activity (JA) on the.fragments of the ischemic kidney and plasma renin activity (PRA) in peripheral venous blood were studied in 26 renovascular patients. In 11 cases PRA was also measured in renal venous blood. JGCC and JA values were always above normal range and both were significantly related to the PRA values in peripheral venous blood, while only JA was related to the PRA values in renal venous blood. These data indicate that in human renovascular hypertension the juxtaglomerular apparatus is hyperplastic and hypergranulated: the correlation between its morphological appearance and PRA seems to indicate that the renin-angiotensin system may be in some way involved in the genesis of hypertension.

ISSN:1660-8151    

DOI:10.1159/000180892

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Plasma renin reactivity (PRR) is the in vitro rate of angiotensin generation after addition of exogenous renin to plasma. The purpose of the present study is to compare measurements of PRR in venous effluent from the involved and uninvolved kidneys in both experimental and clinical renovascular hypertension. A two-kidney model of experimental hypertension was created by placing an ameroid resin constrictor around one renal artery in each of seven dogs. Plasma renin activity (PRA) in venous plasma from the involved kidney increased (p < 0.001); comparing PRA in venous effluent from the stenotic and nonstenotic kidneys, the PRA ratio also increased (p 0.8). These results suggest that measurement of renal venous PRR is not helpful in confirming a diagnosis of renovascular hypertension

ISSN:1660-8151    

DOI:10.1159/000180893

出版商:S. Karger AG    

年代:1977

数据来源: Karger

摘要:

Thyroid function was evaluated in 24 children (aged 4–18 years) with chronic renal failure either before institution of hemodialysis or after more than 3 months of hemodialysis. 22 patients were clinically euthyroid and 2 were hypothyroid; in one case hypothyroidism was secondary to cystinosis and in the other it followed radiation therapy. The 2 hypothyroid patients had subnormal levels of T4, T3, FTI and FT4 as well as elevated serum TSH levels. Mean values for T4, T3, FTI and FT4 for the remaining 22 patients were within the normal range, but were significantly decreased, (all p values < 0.01) when compared to controls. TSH and TBG levels were not significantly different from those of the normal population. Eleven of the euthyroid patients (50%) had either T3 or FT4, but not both, below the normal range without elevation of their TSH levels. These findings suggest that in the absence of other causes of hypothyroidism, children with chronic renal failure are able to maintain a clinically euthyroid state with either normal FT4 or T3 serum levels and can respond to primary gland failure with elevated TSH secretio

ISSN:1660-8151    

DOI:10.1159/000180894

出版商:S. Karger AG    

年代:1977

数据来源: Karger