|
1. |
Analgesic Nephropathy Still a Problem? |
|
Nephron,
Volume 64,
Issue 4,
1993,
Page 505-513
Marc E. De Broe,
Monique M. Elseviers,
Preview
|
PDF (1981KB)
|
|
ISSN:1660-8151
DOI:10.1159/000187392
出版商:S. Karger AG
年代:1993
数据来源: Karger
|
2. |
Rate of Production of Carbon Dioxide in Patients with a Severe Degree of Metabolic Acidosis |
|
Nephron,
Volume 64,
Issue 4,
1993,
Page 514-517
Kamel S. Kamel,
Robert M.A. Richardson,
Jeannette M. Goguen,
Adrian Fine,
Adeera Levin,
Mitchell L. Halperin,
Preview
|
PDF (695KB)
|
|
ISSN:1660-8151
DOI:10.1159/000187393
出版商:S. Karger AG
年代:1993
数据来源: Karger
|
3. |
Nitric Oxide: An Inflammatory Mediator of Glomerular Mesangial Cells |
|
Nephron,
Volume 64,
Issue 4,
1993,
Page 518-525
Josef Pfeilschifter,
Dieter Kunz,
Heiko Mühl,
Preview
|
PDF (1815KB)
|
|
ISSN:1660-8151
DOI:10.1159/000187394
出版商:S. Karger AG
年代:1993
数据来源: Karger
|
4. |
Hyperoxaluria Is Not a Cause of Nephrocalcinosis in Phosphate-Treated Patients with Hereditary Hypophosphatemic Rickets |
|
Nephron,
Volume 64,
Issue 4,
1993,
Page 526-531
Martin Tieder,
Judith Blonder,
Simon Strauss,
Uri Shaked,
Joseph Maor,
Daniela Gabizon,
Hana Manor,
Ben-Ami Sela,
Preview
|
PDF (1315KB)
|
|
摘要:
The treatment of X-linked hypophosphatemia (XLH) consists of phosphate and vitamin D3 derivatives. Transient hypercalciuria and hypercalcemia are well-known signs of vitamin D intoxication. Despite urinary calcium excretion control, the danger of nephrocalcinosis in treated patients has been emphasized. It has recently been suggested that hyperoxaluria might be a causative factor of nephrocalcinosis other than calcium in phosphate-treated XLH patients. We measured urinary oxalate and phosphate excretion in 12 patients with the syndrome of hereditary hypophosphatemic rickets with hypercalciuria (HHRH) receiving only oral phosphates and in 5 XLH patients receiving both oral phosphates and vitamin D. No correlation was found between the dosage of phosphate supplements or urinary phosphate excretion and urinary oxalate excretion, in either group of patients. Nephrocalcinosis, presenting as hyperechogenicity of the medullary pyramids, was found in 2 of the 5 XLH patients and only in 2 HHRH patients who had been treated with excessive doses of vitamin D2 and calcium, prior to the true diagnosis being established. We conclude: (1) hyperoxaluria is not a cause of nephrocalcinosis in phosphate-treated patients with hereditary hypophosphatemic rickets; (2) prolonged phosphate treatment alone does not induce nephrocalcinosis in HHRH patients, and (3) we believe that in XLH patients, nephrocalcinosis is essentially due to vitamin D overdosage at some stage, or noncompliance in phosphate intake, leading to repeated undetected hypercalciuric periods.
ISSN:1660-8151
DOI:10.1159/000187395
出版商:S. Karger AG
年代:1993
数据来源: Karger
|
5. |
The Goodpasture Antigen: Common Epitopes in the Globular Domains of Collagen IV |
|
Nephron,
Volume 64,
Issue 4,
1993,
Page 532-539
Hiro Matsukura,
Ralph J. Butkowski,
Alfred J. Fish,
Preview
|
PDF (1695KB)
|
|
摘要:
To determine the nature of Goodpasture antibody-reactive epitopes on the globular domains of collagen IV [non collagenous (NC) domain], Goodpasture antigen was characterized by immunochemical and immunohistological techniques using affinity-purified (AP) Goodpasture autoantibodies. Affinity purification of Goodpasture autoantibodies toward α1(IV), α2(IV), and α3(IV) NC domains was performed and revealed antigenic cross-reactivity with all α(IV) NC domain subunits, which was confirmed by inhibition ELISA. Since by immunofluorescent microscopy all 3 AP Goodpasture antibodies only stained the central portion (lamina densa) of bovine glomerular basement membrane, it appears that there are common epitopes reactive with Goodpasture autoantibodies present on α1(IV) NC, α2(IV) NC, and α3(IV) NC d
ISSN:1660-8151
DOI:10.1159/000187396
出版商:S. Karger AG
年代:1993
数据来源: Karger
|
6. |
Dynamics of Bone Aluminum over One Year of Functioning Renal Graft |
|
Nephron,
Volume 64,
Issue 4,
1993,
Page 540-546
Gabriele Bertolone,
Mario Andriani,
Ermanno Bonucci,
Paola Ballanti,
Sergio Costantini,
Rosa Giordano,
Giorgio Mattiello,
Gilberto Calconi,
Maria Cristina Maresca,
Nicoletta Galardi,
Piergianni Calzavara,
Maurizio Nordio,
Antonio Piccoli,
Preview
|
PDF (1558KB)
|
|
摘要:
The concentration of aluminum (Al) in serum, urine, and bone, as well as bone histomorphometry parameters were studied before and 1 year after kidney transplantation (Tx) in 20 dialyzed patients. One year after Tx, serum Al fell significantly from 50.3 ± 8.8 to 23.9 ± 2.7 μg/l, (53% fall). Bone Al content also decreased significantly from 62.9 ± 9.0 to 36.5 ± 7.0 μg/kg bone weight, but urine Al excretion was still above normal. The repeat bone histomorphometric examination showed a good recovery of bone resorption which correlated well with serum parathyroid hormone levels, but poorer recovery of indices of bone formation and of the extent of Al deposits in the bone as shown by aluminon sta
ISSN:1660-8151
DOI:10.1159/000187397
出版商:S. Karger AG
年代:1993
数据来源: Karger
|
7. |
Partial Purification of a Renotropic Activity from Plasma of Uninephrectomized Human Subjects |
|
Nephron,
Volume 64,
Issue 4,
1993,
Page 547-551
Adolfo García-Ocaña,
José Ortega,
Yolanda González-García,
César García-Cantón,
Pedro Esbrit,
Preview
|
PDF (951KB)
|
|
摘要:
A renotropic factor was partially purified by sequential gel filtration and anion exchanger chromatography from plasma of human kidney transplantation donors and a renal cancer patient after uninephrectomy. This activity increased the rate of [3H]thymidine incorporation into DNA in rat cortical tubules, but not in rat liver cells, within the range of 100-200 ng/ml protein. The renotropic activity was detected between 7 and 12 days after uninephrectomy, and at least in 1 case decreased thereafter. This activity was undetected in gel-filtrated plasma of patients after a nonurological surgical procedure. The potency of this renotropic activity and its elution by gel filtration are similar to those displayed by a renal growth factor activity isolated from uninephrectomized rat plasma, as recently reported.
ISSN:1660-8151
DOI:10.1159/000187398
出版商:S. Karger AG
年代:1993
数据来源: Karger
|
8. |
Effect of Hemodialysis on Plasma Levels of Vasoactive Peptides: Endothelin, Calcitonin Gene-Related Peptide and Human Atrial Natriuretic Peptide |
|
Nephron,
Volume 64,
Issue 4,
1993,
Page 552-559
Toshimitsu Niwa,
Toshitaka Fujishiro,
Kanji Uema,
Tetsuya Tsuzuki,
Yoshihiro Tominaga,
Yutaka Emoto,
Takashi Miyazaki,
Kenji Maeda,
Preview
|
PDF (1423KB)
|
|
摘要:
To determine the role of vasoactive peptides such as endothelin (ET), calcitonin gene-related peptide (CGRP) and human atrial natriuretic peptide (hANP) in the regulation of blood pressure in uremic patients, and to determine the effect of various types of dialyzer membranes on hemodialysis (HD)-induced changes in plasma levels of such peptides, plasma ET, CGRP and hANP were measured in HD patients and patients on continuous ambulatory peritoneal dialysis (CAPD). Plasma levels of ET, CGRP, and hANP were significantly higher in HD and CAPD patients than in healthy subjects. There were no significant differences in plasma levels of ET, CGRP, and hANP between hypertensive and normotensive HD patients, and no significant correlation was observed between HD-induced changes in plasma levels and changes in blood pressure. Plasma levels of ET decreased when HD was performed using high-flux membranes, such as polyacrylonitrile (PAN), polymethyl methacrylate (PMMA) and cellulose triacetate (CTA), but did not decrease using a saponified cellulose (SC) membrane. Plasma levels of CGRP decreased in the case of PAN, but increased significantly with PMMA and showed no change with SC and CTA. Plasma levels of hANP decreased in all types of dialyzer membranes due to decreased secretion. These results indicate that the effect of HD on plasma levels of ET and CGRP, but not hANP, depends on the type of dialyzer membrane used.
ISSN:1660-8151
DOI:10.1159/000187399
出版商:S. Karger AG
年代:1993
数据来源: Karger
|
9. |
Lipoprotein (a) Levels in End-Stage Renal Failure and Renal Transplantation |
|
Nephron,
Volume 64,
Issue 4,
1993,
Page 560-564
C.M. Barbagallo,
M.R. Averna,
V. Sparacino,
A. Galione,
E. Caputo,
V. Scafidi,
S. Amato,
C. Mancino,
A.B. Cefalù,
A. Notarbartolo,
Preview
|
PDF (1048KB)
|
|
摘要:
Some previous studies have documented an increase in lipoprotein (a) [Lp(a)] levels in renal diseases. Here, we report data in subjects with end-stage renal failure treated with hemodialysis (HD) or with continuous ambulatory peritoneal dialysis (CAPD) and in renal transplant recipients (RTR), compared with a group of normolipidemic controls (C). Lp(a) levels were significantly increased in HD and CAPD patients in comparison with C, while they were only slightly increased in RTR. Both HD and CAPD patients showed Lp(a) levels higher than in RTR, but no difference was found between the subjects of the two dialysis procedures. The prevalence of Lp(a) levels > 25 mg/dl was significantly higher in HD and CAPD patients, but not in RTR, in comparison with C. Moreover, Lp(a) levels did not change after HD. When patients were divided according to their fasting lipid levels in normolipidemics and hyperlipoproteinemics, no difference was found for Lp(a) levels in any group. Mechanisms underlying the increase in Lp(a) levels in these patients are not known. It is possible to suggest an active role of the kidney in the Lp(a) metabolism or that uremic plasma contains some factors affecting Lp(a) metabolism.
ISSN:1660-8151
DOI:10.1159/000187400
出版商:S. Karger AG
年代:1993
数据来源: Karger
|
10. |
Pattern of Hyperlipoproteinemia in Human Nephrotic Syndrome: Influence of Renal Failure and Diabetes mellitus |
|
Nephron,
Volume 64,
Issue 4,
1993,
Page 565-569
J. Joven,
C. Villabona,
E. Vilella,
Preview
|
PDF (927KB)
|
|
摘要:
Forty-two patients with the nephrotic syndrome were grouped according to the absence or presence of renal failure and/or diabetes mellitus. All patients had a similar degree of hypoalbuminemia and urinary protein losses. A lipid and apoprotein pattern was generated in serum and ultracentrifugally isolated lipoproteins. Low-density lipoprotein composition was essentially normal in uremic patients while in the other patients with the nephrotic syndrome, a considerable lipid enrichment was noted. The very-low-density lipoprotein content in lipids was uniformly increased in nephrotic patients irrespective of the presence of complications. High-density lipoprotein cholesterol and serum apolipoprotein A I and E concentration was significantly reduced in uremic patients with respect to normal subjects and to the other groups considered. Serum apolipoprotein A II and B levels were also decreased in uremics. All patients had increased serum apoprotein C II and C III concentration. We conclude that diabetes mellitus does not affect the pattern of hyperlipoproteinemia of nephrotic syndrome while the characteristic lipoprotein and apoprotein pattern of uremia is present irrespective of nephrosis in uremic, nondiabetic patients.
ISSN:1660-8151
DOI:10.1159/000187401
出版商:S. Karger AG
年代:1993
数据来源: Karger
|
|