ISSN:1660-8151    

DOI:10.1159/000180749

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A randomized, controlled study of the effect of alternate-day prednisone therapy on renal transplant recipients was done on 53 patients followed for 610 patient months. There was no difference between the 17 recipients of related donor organs who received alternate-day prednisone (experimentals) and their 15 controls who received daily prednisone nor between the 11 experimental and 10 control recipients of cadaver donor organs as regards: rejections per patient month, change in serum creatinine, doses of azathioprine or prednisone, or weight. Likewise the controls and experimentals of the related and cadaver groups did not seem different in either their blood pressure change or their tendency to lose their Cushingoid facies. Alternate-day steroids had no obvious effect on the development of posterior subcapsular cataracts in either related or cadaver organ recipients.

ISSN:1660-8151    

DOI:10.1159/000180750

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

The effects of intravenous iron, with and without androgens, was studied in a group of 39 patients treated by regular haemodialysis, almost all of whom had normal serum iron concentrations. Intravenous iron 1–2 g every 4 months produced a significant rise in haemoglobin from 6.3 to 7.9 g/dl in 17 female patients with their kidneys in situ (p < 0.001). In a group of 13 male subjects intravenous iron plus testosterone produced a similar rise in haemoglobin from 6.9 to 8.6 g/dl (p < 0.001). Nine nephrectomised patients showed no significant response to iron and androgens. There were no fatalities and no serious side effects in 500 courses of intravenous iro

ISSN:1660-8151    

DOI:10.1159/000180751

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Ferrokinetic studies were made in 16 patients before and after kidney transplantation. The Fe clearance decreased in 9 of 11 patients, the plasma iron turnover showed no variation in six patients, while it increased in three and decreased in one, the production of hemoglobin increased significantly after transplantation. The nonnephrectomized patients showed more erythropoiesis after transplantation, manifested by higher hemoglobin level, shorter Fe clearance, and lower serum iron. Uremic patients, including the anephric, had significant responses in erythropoiesis both to stimulation by phlebotomy and to inhibition by blood transfusion. After transplantation, however, the response to phlebotomy was greater and the blockade by blood transfusion smaller, than during uremia.

ISSN:1660-8151    

DOI:10.1159/000180752

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

34 adult patients with membranoproliferative glomerulonephritis are reviewed; the diagnosis was based on histological studies, by light and electron microscopy. Hypocomplementemia was detected in 67.6% of the cases; the C3 depression was associated with normal early complement components (82.5%) and low levels of C3 PA (65.2%). In the serum of ten hypocomplementemic patients the presence of circulating factor, which is able to break down the normal C3in vitro, was found. Immunofluorescence deposits of C3 were present in 100% of the cases, IgM in 92, IgG in 86, IgA in 30, C1q in 53 and C4 in 46% of the cases. Only in a few cases there was a correlation between serum complement profile and the immunofluorescence pattern. Hypocomplementemic patients with ‘classical’ pathway activation seemed to have a worse clinical course than the others. The results of humoral and cellular immunity studies do not permit to draw any clear conclus

ISSN:1660-8151    

DOI:10.1159/000180753

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Renal acidification was studied in eight patients with Addison’s disease or bilateral adrenalectomy receiving glucocorticoid replacement only and without renal insufficiency (group I); in five patients with hyporeninemic hypoaldosteronism and moderate chronic renal insufficiency (group II), and in nine control subjects (group III). During acidosis minimal urine pH was 5.4 or less in all subjects, but excretion of ammonium and titratable acid was moderately reduced in group I and markedly reduced in group II. Bicarbonate excretion at normal serum bicarbonate concentration was trivial in group I subjects and inappropriately elevated in two group II patient

ISSN:1660-8151    

DOI:10.1159/000180754

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

Deficiences in acid excretion during hypercalcemia have been reported, and this defect has been ascribed to a deficiency in ammonia excretion. Because no changes in urine pH and urine flow occurred to explain decreased ammonia excretion, this suggested to us that decreased excretion was secondary to decreased renal ammonia production. To test this hypothesis, we investigated the ability of kidney slices from rats to produce ammonia and glucose and to consume oxygen when incubated in varying concentrations of calcium. High medium concentrations of calcium (3 and 4 mM) decreased kidney slice ammoniagenesis from glutamine and glutamate and kidney slice oxygen consumption while not affecting gluconeogenesis. Based upon our findings, we propose that hypercalcemia decreases urine ammonia excretion by depressing renal ammonia production.

ISSN:1660-8151    

DOI:10.1159/000180755

出版商:S. Karger AG    

年代:1976

数据来源: Karger

摘要:

A case of juxtaglomerular cell tumor, the fourth case in the world diagnosed preoperatively, was reported. Neither strict sodium restriction nor loading of upright position increased a grade of hyperreninemia observed at recumbent position on ordinary diet, but Paid elevated in response to them. Abnormal glucose tolerance was considered to be due to hypopotassemia. Selective renal arteriography revealed a small number of tumor vessels, a lucent area on the nephrogram and early appearance of the renal vein of the diseased side. Histologically, the tumor contained some canalicular structures among the polygonal nonepithelial tumor cells with rhomboid bodies. These findings suggested that this tumor was a hamartoma originated from the juxtaglomerular apparatus.

ISSN:1660-8151    

DOI:10.1159/000180756

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000180757

出版商:S. Karger AG    

年代:1976

数据来源: Karger

ISSN:1660-8151    

DOI:10.1159/000180758

出版商:S. Karger AG    

年代:1976

数据来源: Karger