摘要:

Goodpasture’s syndrome is thought to be caused byan immunological disorder in which antibodies are directed against the glomerular and alveolar capillary basement membranes. The recognition of this process has been simplified by the technique of immunofluorescent staining; a linear staining pattern against IgG and C3 is found in Goodpasture’s syndrome. A case is presented in which two specimens of renal tissue taken at different stages of the illness, were examined by this technique. Immunofluorescent findings were negative in the first of these specimens, but were positive in the second specimen. Such findings cast doubt on any simple immunological explanation of the dise

ISSN:1660-8151    

DOI:10.1159/000180213

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Four patients with a paucity of peripheralveins had cervical arteriovenous fistulae created, utilizing the external jugular vein and either the superior thyroid artery or the external carotid artery. The fistulae provided a reasonably adequate solution for maintenance hemodialysis in these patients with chronic renal failure.

ISSN:1660-8151    

DOI:10.1159/000180214

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Glycoprotein: sialic acid transferase activity wasstudied in kidney tissue utilizing as exogenous acceptors desialized fetuin and desialized Tamm-Horsfall urinary glycoprotein. Activities were determined in cortex, medulla, and glomeruli. The effect of pH, divalent cations, and different protein acceptors was noted. The identity of the radioactive product formed was shown to be [14C]-N-acetylneuraminic acid labeled glycoprotein by hydrolysis and isolation of the radioactivity. This enzyme activity may prove useful in the study of renal pathology.

ISSN:1660-8151    

DOI:10.1159/000180215

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Properties of particle-bound neuraminidase activity of ratkidney were studied using a colorimetric assay for measuring released free sialic acid; several glycoproteins were used as substrates. Neuraminidase specific activities of cortex and medulla were similar, but lower activity was obtained with glomerular preparations. The nonionic detergent Triton X-100 solubilized the neuraminidase but had a moderately inhibitory effect on its activity. Substrate competition studies indicated the presence of only one enzyme in rat kidney. Tritium sialic acid-labeled fetuin and Tamm-Horsfall glycoprotein were used as substrates in a radioactive assay for kidney neuraminidase. This assay system permits detection of low levels of activity when combined with a chromatographic procedure for separating free sialic acid.

ISSN:1660-8151    

DOI:10.1159/000180216

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

Total and intrarenal distribution of blood flow was determined repeatedly in five unanesthetized dogs using the 85Kr method. No consistent effect of oxytocin (syntocinon) could be demonstrated. Eleven anesthetized dogs showed similar TRBF variability. However, intravascular silicone rubber injections and autoradiographs suggest a postglomerular (vasa rectae) dilation in response to oxytocin. Water intoxication occurs in dogs given massive doses of oxytocin with a water load as is seen in man. Kidneys from pregnant, postpartum and suckling bitches show the similar vasa rectae dilation to that induced with oxytocin. Progesterone also appears to have some effect. Estrogen and oxytocin appears to interact diminishing cortical flow with little effect on the vasa rectae. No interaction of oxytocin and autonomic blocking agents, prostaglandin A1 or F2a or chorionic gonadotropins was demonstrated.

ISSN:1660-8151    

DOI:10.1159/000180217

出版商:S. Karger AG    

年代:1973

数据来源: Karger

摘要:

There is evidence to suggest that the sympatheticnervous system plays a role in the regulation of renal sodium excretion. In the present experiments, the pattern of renal sodium and water excretion following the intravenous infusion of pro pranolol (a β-adrenergic blocking agent) was studied by clearance techniques in nine normal dogs under hydropenic conditions undergoing a modest mannitol diuresis. Blood pressure and pulse rate were monitored throughout. Following systemic administration of propranolol there was a significant decrease in fractional sodium excretion of 2.0 ml/min/100 ml GFR. This occurred despite a 14.2-percent increase in glomerular filtration rate. Potassium excretion and solute-free water reabsorption decreased. There were no significant or predictable changes in heart rate, mean arterial blood pressure, effective renal plasma flow or filtration fraction. These data indicate that propranolol increases renal tubular sodium reabsorption in the dog and suggest that the site of action is in the proximal tubule. Moreover, the data suggest that the mechanism of action is not primarily related to alterations in systemic or renal hemodynamics but may be due to a direct effect on renal tubular sodium transport

ISSN:1660-8151    

DOI:10.1159/000180218

出版商:S. Karger AG    

年代:1973

数据来源: Karger