摘要:

34 patients with chronic renal failure, 20 on periodic hemodialysis and 14 without dialysis, were evaluated for defects in iron stores, folic acid deficiency and renal osteodystrophy. A high incidence of abnormalities in iron stores was observed on bone marrow biopsy. The estimation of iron stores by means of serum iron and percent saturation measurements were unreliable. Significant folic acid depletion was an infrequent finding. The biochemical measurement of serum calcium or inorganic phosphorus had little predictive value in terms of renal osteodystrophy as demonstrated on bone marrow biopsy while serum alkaline phosphatase changes were of limited usefulness. Dialyzed patients generally had lesser abnormalities in iron studies as well as in bone assessments. The study suggests that bone marrow biopsy is a more reliable method of evaluating patients with chronic renal failure for iron abnormalities as well as for osteodystrophy as compared to the usually employed laboratory tests.

ISSN:1660-8151    

DOI:10.1159/000180270

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The effect of 2 urease inhibitors, hydroxyurea and thiourea, on experimental ascending pyelonephritis by P. mirabilis was studied in mice undergoing water diuresis. It was found that hydroxyurea significantly diminished the number of bacteria in the kidneys, the severity and number of lesions as well as the number of excreted bacteria. Thiourea, a weaker inhibitor, was less effective. The drugs prevented the establishment of infections but did not eliminate already existing ones. The mechanisms of hydroxyurea action were studied, as this drug also inhibits DNA synthesis. Hydroxyurea did not prevent infections by (urease-negative) E. coli, and selectively suppressed P. mirabilis in a mixed infection with E. coli.

ISSN:1660-8151    

DOI:10.1159/000180271

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Eight patients treated with maintenance hemodialysis developed significant ascites. Fluid retention appears to be a common denominator. Increased capillary permeability from uremia may be a contributory factor. Compartmentalization of ascitic and nonascitic fluids is often observed. Therapeutic measures include fluid and sodium restriction, fluid removal by dialysis, abdominal paracentesis, intravenous infusion of ascitic fluid or albumin and renal transplantation. The latter appears to be the ideal therapy.

ISSN:1660-8151    

DOI:10.1159/000180272

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Intractable ascites is encountered with increasing frequency in patients undergoing chronic hemodialysis. Eight patients out of 68 developed moderate to massive ascites. Peritoneal dialysis antedated hemodialysis in all of them and the duration on either form of dialysis bore no relationship to the appearance of ascites. Congestive heart failure, when present, responded well to ultrafiltration by peritoneal dialysis; ascites always reaccumulated rapidly. There was no evidence of liver dysfunction; liver and peritoneal histology did not reveal any specific pattern. Therapy with increased dialysis time, and repeated infusions of albumin and whole blood proved futile. Five out of eight patients died 2-18 months after onset of ascites, two of them from entirely unrelated events. Two patients were cured of ascites following renal transplantation and another (not transplanted) is alive and well 21 months later even though the ascites is persistent. We conclude that intractable ascites of idiopathic origin is not uncommon in patients on chronic hemodialysis and renal transplantation is the only definitive treatment.

ISSN:1660-8151    

DOI:10.1159/000180273

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

An intravenous injection of 20 mg of Furosemide followed by 500 ml normal saline was given to 60 hospital patients investigated for symptoms of urinary tract infection, of whom 36 had positive urine cultures. The subjects were separated into 4 groups, depending on the pre- versus post-diuretic changes in urine cultures; i.e. 16 steadily negative, 8 negative turning positive, 24 steadily positive, and 12 positive turning negative. The data indicate that a ‘steadily positive’ or ‘turning positive’ urine culture after furosemide is associated with upper urographic abnormalities, and more advanced renal functional impairment than a ‘turning negative’ or ‘steadily negative’ urine. It is pointed out that the direction of bacterial excretion changes, combined with pyelographic data and functional tests, is more specific of intrarenal infection than the absolute initial or fina

ISSN:1660-8151    

DOI:10.1159/000180274

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

Another form of the short ammonium chloride loading test is proposed. Ammonium chloride was given by mouth in 5 doses. The urine was collected during 6 h. No indwelling urethral catheters were used. In this test an increase in ammonia excretion with age could not be demonstrated, which is quite different from the results obtained during the long ammonium chloride loading test.

ISSN:1660-8151    

DOI:10.1159/000180275

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

A clinical experience in the treatment of arterial hypertension based only on the administration of high doses of furosemide and sodium is reported. Ten cases of severe hypertension showed a decrease of their blood pressure from the mean value of 153.8 ± 9.7 to 121.1 ± 6.3 mm Hg. This effect was found to be significantly better than that previously obtained with the conventional antihypertensive therapy and was also followed by improvement in the complications of hypertension detected in several cases. No side effects were observed and the gross polyuria induced by the treatment was well tolerated. Orthostatic hypotension has not been observe

ISSN:1660-8151    

DOI:10.1159/000180276

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The effects of furosemide on the in vitro performances of isolated prestored (24-hour storage in Collins solution) and control unstored canine kidneys were studied on the Nizet pump oxygenator. Prestorage reduced RBF, GFR, Na reabsorption rate and PAH extraction, while it increased free water clearance and K excretion rate. In prestored kidneys, the addition of furosemide to perfusing blood did not improve the hemodynamic parameters and did not influence PAH transport despite its usual effects on Na, K and water excretion. Moreover, in unstoredkidneys, furosemide somewhat decreased RBF and GFR.

ISSN:1660-8151    

DOI:10.1159/000180277

出版商:S. Karger AG    

年代:1974

数据来源: Karger

摘要:

The possibility of evaluating albumin and α-2 macroglobulin clearances has been investigated, on unconcentrated urine samples, using a sensitive method (Laurell’s ‘rocket’ electrophoresis on cellulose acetate gel) in order to assess its adaptability in clinical practice.In 37 patients, presenting glomerular proteinuria, Cl α-2-M/Cl Alb. and Cl IgG/Cl Transf. have been compared. The correlation is satisfactory in all histological groups considered, with the interesting exception of focal glomerulosclerosis and amyl

ISSN:1660-8151    

DOI:10.1159/000180278

出版商:S. Karger AG    

年代:1974

数据来源: Karger