摘要:

AbstractThe lifetime intake of total alcohol, beer, wine, and hard liquor was measured for 277 males and 145 females with pathologically confirmed, first, single, primary cancers of the rectum in western New York from 1978 to 1986. Controls who were age, sex, and neighborhood matched were also interviewed. Intake of beer and total alcohol was positively associated with rectal cancer risk. Most of the excess risk was found for the heaviest drinkers. Odds ratios for fourth quartile intakes for males were 1.80 (95% CI, 1.12, 2.89) for total alcohol and 1.86 (1.13, 3.06) for beer. No association was found with wine or hard liquor intake. Females drank considerably less in this population; trends were similar although not of as great magnitude as those for males. Adjustment for dietary risk factors did not change risk estimates appreciably. A high lifetime intake of beer and total alcohol was associated with an increased risk of rectal cancer, and this was independent of either socioeconomic status or diet.

ISSN:0163-5581    

DOI:10.1080/01635589009514050

出版商:Taylor&Francis Group    

年代:1990

数据来源: Taylor

摘要:

AbstractThe effect of dietary lipids on hepatic and intestinal monooxygenases was studied by feeding C57BL/6N mice (for 2 wks) diets containing 5% and 23.5% (wt/wt) olive oil or corn oil. At the end of the feeding period, we measured arylhydrocarbon hydroxylase (AHH) activity in S9 preparations from liver, small intestine, and colon; and, using the same S9 preparations from the liver, we observed the activation of the following three dietary promutagens:2‐amino‐3‐methylimidazo(4,5‐f)quinoline,2‐amino‐3,8‐dimethylimidazo(4,5‐f) quinoxaline, and 2‐amino‐6‐methyldipyrido(l,2‐a:3’,2'‐d)imidazole. The results showed that high‐fat diets increased hepatic AHH activity both in corn oil and olive oil diets compared with the low‐fat diets; also, a 5% corn oil diet had significantly higher AHH activity compared with the 5% olive oil diet. AHH activity was, respectively, 48.6±5.1 and 79.5±11.4 pmol3OH‐benzo[a]pyrene formed/mg/min in the 5% and 23.5% olive oil diets and 66.1±5.1 and 83.9±12.2 in the 5% and 23.5% corn oil diets; values are means±SE, n = 16. The results also showed a significant increase in the ability of hepatic S9 fractions from animals on high‐fat diets to activate promutagens in the Salmonella/plate test. On the contrary, AHH activity in the small intestine and colon was not affected by the fat content of the diet.

ISSN:0163-5581    

DOI:10.1080/01635589009514051

出版商:Taylor&Francis Group    

年代:1990

数据来源: Taylor

ISSN:0163-5581    

DOI:10.1080/01635589009514039

出版商:Taylor&Francis Group    

年代:1990

数据来源: Taylor