ISSN:0163-5581    

DOI:10.1080/01635588609513874

出版商:Taylor&Francis Group    

年代:1986

数据来源: Taylor

摘要:

AbstractCasein and egg albumin were reacted with nitrite at pH3. The reaction mixtures containing nitrite yellowed when the reaction began; after 24 hours of reaction with 7.5×10‐3M nitrite, about 70% of added casein was sedimented as yellow precipitate. There was a considerable loss of lysine, arginine, tyrosine, and tryptophan residues. This was determined from the amino acid compositions of the proteins obtained by the reaction with 2.5×10‐2M nitrite at pH 3 for 48 hours. An amino acid elution pattern of the treated casein showed five peaks due to new amino acids; three of these were provisionally identified to be cysteic acid, methionine sulfone, and 3‐nitrotyrosine.

ISSN:0163-5581    

DOI:10.1080/01635588609513875

出版商:Taylor&Francis Group    

年代:1986

数据来源: Taylor

摘要:

AbstractThis review presents a critical, select evaluation of the amount and type of fat or fiber in nutritional carcinogenesis, with the emphasis being on cancer development in the mammary gland and large bowel. The role of nitrate and nitrosation is described in relation to risk for cancers of the head and neck (especially the esophagus) and cancers of the stomach and the liver. Systematic tests of increasing complexity to delineate possible carcinogenic risk in food additives and contaminants are described. Specific recommendations stemming from these evaluations are made as to dietary recommendations designed to reduce cancer risk.

ISSN:0163-5581    

DOI:10.1080/01635588609513876

出版商:Taylor&Francis Group    

年代:1986

数据来源: Taylor

摘要:

AbstractDimethylnitrosamine (NDMA), diethylnitrosamine (NDEA), methylbenzylnitros‐amine, and a new N‐nitroso compound, N‐3‐methylbutyl‐N‐1‐methylacetonylnitrosamine (NMAMBA), were found in cornbread that was inoculated withFusarium monilif ormeand underwent an incubation and the addition of a small amount of NaNO2. The carcinogenicity of NMAMBA was shown by the induction of forestomach carcinomas and liver tumors in mice and rats. Another new nitrosamine, N‐2‐methylpropyl‐N‐methylacetonylnitrosamine, was isolated in millet and wheat flour after similar treatment. Some species of fungi not only can reduce nitrates to nitrites but also can increase the amount of secondary amines in the moldy foods and pro vide favorable conditions for the synthesis of nitrosamines. Some fungi may utilize primary amines to synthesize nitrosamines in appropriate culture mediums.Furthermore, the cornmeal may naturally contain trace amounts of nitrosamines, as detected by a gas chromatography/thermoenergy analyzer. Prolonged feeding ofF. moniliforme‐inoculated cornbread alone also induced the development of forestomach carcinoma in rats. This indicates the occurrence of potential carcinogens, perhaps certainFusariummycotoxins, in the moldy cornbread in addition to the carcinogenic nitrosamines. Another nitroso compound, Roussin red methylester (di‐μ‐methanethiolatotetranitrosodiiron) was found in pickled vegetables that are eaten daily in the Linxian (China) area. Roussin Red may provide NO‐2ions, which would react readily with secondary amines to form nitrosamines. Possibly this compound is a natural tumor promoter and is able to induce epithelial hyperplasia of the upper digestive tract and forestomach papilloma in treated mice. Also, trace amounts of NDMA, NDEA, and some other nitrosamines were found in the extract of pickled vegetables.

ISSN:0163-5581    

DOI:10.1080/01635588609513877

出版商:Taylor&Francis Group    

年代:1986

数据来源: Taylor

ISSN:0163-5581    

DOI:10.1080/01635588609513862

出版商:Taylor&Francis Group    

年代:1986

数据来源: Taylor